DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Cntnap4

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001100902.1	Gene:	Cntnap4 / 307865	RGDID:	1306459	Length:	1310	Species:	Rattus norvegicus

Alignment Length:	1374	Identity:	430/1374 - (31%)
Similarity:	654/1374 - (47%)	Gaps:	213/1374 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPL---MERAVLTATSSL-TERGPDKARLN---GN 76
            |..||||.......|:|.      :.|||::.|   :.:|..:::|.| :..||..||||   |.
  Rat    11 LKMLLLLSTQNWNRVEAG------NSYDCDEALVSALPQASFSSSSELSSSHGPGFARLNRRDGA 69

  Fly    77 AAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQM 141
            ..|:|:.:....:|.:|||:...|..:||.|...:..:||.|::.:||.|..|:.|   ..|..:
  Rat    70 GGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSGRNWKQY---RQEDSI 131

  Fly   142 --FKGNSDGNSIHYNVFEVPIIAQWVRINPTRWH--DRISMRVELYGCDYISENLYFNGTGLVRY 202
              |.||::.:|:.|...:..|.|:::|..|..|:  .||:||:|::||.|.|..:..:|...:.|
  Rat   132 WGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIAMRIEVFGCAYRSVVIDLDGKSSLLY 196

  Fly   203 DLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTS----- 262
            ...:..::..::.|..:|||..::|::::..|..||:..|:|:..|:.|.:..|...:||
  Rat   197 RFDQNSLSPIRDIISLKFKTMESDGILLHRAGPGGDHITLELRRGKLFLLIHSGEARLTSSSRPI 261

  Fly   263 -LSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGL-I 325
             |::||||||..||.|:|.|..:.:.|:||........||||..|:|:.|:..||:....:.: :
  Rat   262 NLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGISAPAKSVSL 326

  Fly   326 VQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKG 390
            ..:.|.|||||:::|..:.|.:.|..:.    .:.|..||.::|..|...|:||.:..|::.|..
  Rat   327 PYKYFRGCLENLFYNGVDVIGLAKQHSP----QIITMGNTSFSCSQPQSMPLTFLSTRSYLVLPA 387

  Fly   391 YENSQRLNVSFYFRTYEETGVMLHHDFY-SGGYLKVFLEFGKVKIDLKVKDK------ARIILDN 448
            ....:.::|||.|||:.:.|::|..:.: ..|.|.:.|..|::|::|....|      |...||
  Rat   388 SSKEEAISVSFQFRTWNKAGLLLFSELWLMSGSLLLSLSDGRLKLNLHQPGKSPSDITAGAGLD- 451

  Fly   449 YDDQFNDGKWHSFVISIEKNRLILNIDQRPMTTTKSM---QVATGAQYYIAGGKDKN-------- 502
                  ||:|||..:|.::|.|.:.:|......:..:   ||.:|..:|..|..||:
  Rat   452 ------DGQWHSVSLSAKRNHLTVVVDGHISPASPWLGPEQVNSGGIFYFGGCPDKSFGSRCKSP 510

  Fly   503 --GFVGCMRLISVD--------------GNYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPC 551
              ||.|||||||:.              ||:               .|:.:|:|.:.|||.||.|
  Rat   511 LGGFQGCMRLISIQDKMVDLLAVQQGSLGNF---------------SDLQIDSCGISDRCLPNSC 560

  Fly   552 QHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLN----LDVDGSGPL 612
            :|.|.|.|:...|.|:|.:|||.||.||:|....||.|.|:      |.|.:    :|.||||||
  Rat   561 EHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCEAYKH------RGNASGFYYIDSDGSGPL 619

  Fly   613 EPFPVTCE--------FYSDGRVITTL--SHSQE-HTTTVDGFQEPGSFEQSIMYDANQLQIEAL 666
            .||.:.|.        .:.:|..:..:  :||:. ||         |.||    |.|:..|::|.
  Rat   620 RPFLLYCNMTETAWTVIHHNGSDLMRVRNAHSENVHT---------GVFE----YVASMGQLQAS 671

  Fly   667 LNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKC 731
            :||:..|.|.|.|.|:.|||.|....:    |.|||:.|.|:...||.|:||..:||.||:.|.|
  Rat   672 INRAEHCQQELVYYCKKSRLVNQQDGS----PRSWWVGRTNETQTYWGGSLPMPQKCTCGLEGNC 732

  Fly   732 HDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSN 796
            .|....||||::..||..|.|.:..||:|||..:...|||.|..|  ..|.||||.|.||..|.|
  Rat   733 IDAQYHCNCDADRNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSE--AAYKLGPLLCRGDRPFWN 795

  Fly   797 VVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGS 861
            ..:|....:.::.|.|....|.|:...|:||..:.|.....|.||:|::.|.....:.|.:..|:
  Rat   796 AASFNTEASYLHFPTFHGELSADVSFYFKTTALSGVFLENLGITDFIRIELRSPTTVTFSFDVGN 860

  Fly   862 GPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRA--------LHLTSD 918
            ||..::|.:..|.|||.||.|.||||.|||.|.||        |.|..::|        |.|.|.
  Rat   861 GPFELSVHSPTHFNDNQWHHVRVERNTKEASLQVD--------ELPPKIQAAPTDGHVLLQLNSQ 917

  Fly   919 LVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLY--GISTGCVGRCES--NPCLNNGTCIE 979
            |.:|.|...:.|::||||:|.|||..:||:|   |...  |:..||.|.|.|  ..|.:.|.|.|
  Rat   918 LFVGGTATRQRGFLGCIRSLQLNGMALDLEE---RATVTPGVQPGCRGHCGSYGKLCRHGGKCRE 979

  Fly   980 RYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSF--------------------RSTI 1024
            :..|:.|||..||:.||.|:.||.....|.|.:.|.|:.::                    |.|:
  Rat   980 KPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLGRETV 1044

  Fly  1025 AENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFG--FERQEIIFPKKHFGLGQ 1087
            ..|.|   ||..|.  ||.:.|:...|||::.|:.:|.|:..:...  .|...|.|..|....||
  Rat  1045 KFNFR---TTRAPS--LLLYMSSFYKEYLSVIIAKNGSLQIRYRLNKYHEPDVISFDLKSMADGQ 1104

  Fly  1088 YHDMHFMRKNGGSTVVLKVD-NYEPVEYNFDIKASADAQFNNIQYMYIGKNESMTD--------- 1142
            .|.:...|:.|  .|.:::| |.....|     .|:..:|:.::.:.:|:....:|
  Rat  1105 LHHLKISREEG--MVFVEIDENTRRQTY-----LSSGTEFSAVKSLVLGRMLEYSDVDQETALAA 1162

  Fly  1143 --GFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPV---------THPPIEIE 1196
              ||.||:|.|||..|.|||...|...|..|...| .:||..| |.|.         ||   ...
  Rat  1163 AHGFTGCLSAVQFSHIAPLKAALQPGRPAPVTVTG-HVTESSC-VAPAGTDATSRERTH---SFA 1222

  Fly  1197 TRPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTHEDQGADGAD 1261
            .....:.|.|.|..|.....:|:...:.|::|:||.:.  .|...:::.|..|..:|.:.::..|
  Rat  1223 DHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVS--AIAVRIYQQKRLYKRNEAKRSENVD 1285

  Fly  1262 DPDDAVLHS 1270
            .. :|||.|
  Rat  1286 SA-EAVLKS 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	47/149 (32%)
		FA58C	57..184	CDD:238014	43/134 (32%)
		LamG	192..340	CDD:238058	47/154 (31%)
		LamG	376..514	CDD:238058	48/157 (31%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	48/126 (38%)
		EGF_CA	966..998	CDD:238011	14/33 (42%)
		Laminin_G_2	1032..1156	CDD:280389	37/137 (27%)
		4.1m	1239..1255	CDD:128590	3/15 (20%)
Cntnap4	NP_001100902.1	FA58C	56..178	CDD:238014	41/124 (33%)
		FA58C	57..179	CDD:214572	41/124 (33%)
		LamG	210..343	CDD:214598	46/132 (35%)
		Laminin_G_2	400..526	CDD:280389	40/132 (30%)
		EGF	555..586	CDD:278437	15/30 (50%)
		FReD	597..>645	CDD:294064	15/53 (28%)
		LamG	796..940	CDD:238058	51/151 (34%)
		Laminin_G_2	1048..1178	CDD:280389	38/141 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3028
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	603	1.000	Inparanoid score	I905
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm45876
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	LDO	PTHR15036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840