DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and LOC304725

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001316828.2	Gene:	LOC304725 / 304725	RGDID:	1592077	Length:	1293	Species:	Rattus norvegicus

Alignment Length:	1334	Identity:	411/1334 - (30%)
Similarity:	658/1334 - (49%)	Gaps:	158/1334 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SDYDCNQPL---MERAVLTATSSLTERGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVR 101
            ::|:|:.||   :.....:::|.:| .....|:||   |...|:|.:::.:.:|.||||:...:.
  Rat    26 TNYNCDDPLASFLSPVAYSSSSDIT-GSTSSAQLNWRMGTGGWSPADSSAHQWLQLDLGNRVEIT 89

  Fly   102 KIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVR 166
            .:||.||..:.::||.|.:.:||.|..|:.|....| ...|.||.:.:|:.::.....:.|:::|
  Rat    90 AVATQGRYGSADWVTSYHLMFSDTGHNWQQYKQENS-IWTFAGNLNADSVVHHKLLHSVRARFIR 153

  Fly   167 INPTRW--HDRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVM 229
            ..|..|  :..|.||||:|||.|.|:...|:|...:.|...::.:::.|:.|..:||:...:||:
  Rat   154 FVPMEWNRNGNIGMRVEVYGCSYKSDVADFDGQSSLLYRFSQKTMSTLKDVISLKFKSMQGDGVL 218

  Fly   230 MYSRGTQGDYYALQLKDNKMVLNLDLG------SRVMTSLSVGSLLDDNVWHDVVISRNQRDIIF 288
            .:..|.:||:..|:|::.::||.|:|.      |.:..|..:||||||..||.|.:.|..:.:.|
  Rat   219 FHGEGQRGDHITLELQNGRLVLYLNLDDKKAWLSSITPSAILGSLLDDQHWHSVFLERVGKQVNF 283

  Fly   289 SVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDST 352
            :|||.......:||...|:::.||..||:| ..:.|..|::||.||:||:|:|..|.|    |..
  Rat   284 TVDRNTQHFWTKGETEVLDIDYELSFGGIPVPSKPGTFVKKNFHGCIENLYYNGVNII----DLA 344

  Fly   353 ELGEGYLFTRVNTIYACPSPPIYPVTF-TTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHD 416
            :..:..:::..|..::|..|.|.|:|| .:|||::.|.|......|:|||.|||:.|.|::|..:
  Rat   345 KRRKHQIYSVGNVTFSCSEPQIVPITFVNSRSSYLFLPGTPQIDGLSVSFQFRTWNEDGLLLSTE 409

  Fly   417 FYSG-GYLKVFLEFGKVKIDL-KVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQRPM 479
            ...| |.|.:.||.|.:::.: ||.......|..  ...|||:|||..|::.:||:.|.:|...:
  Rat   410 LSEGSGTLLLILESGTLRLLIKKVTGHGTESLTG--RSLNDGRWHSVSINVRRNRVTLTVDNDAV 472

  Fly   480 T---TTKSMQVATGAQYYIAGGKDK----------NGFVGCMRLISVDGNYKLPQDWVKGEEVCC 531
            :   .|..:|:.:|..||..|..|.          ..|.||||||.:|..   |:|.:..::...
  Rat   473 SLAPETSGLQIYSGNSYYFGGCPDNLTVSQCLNPIKAFQGCMRLIFIDNQ---PKDLISVQQGSL 534

  Fly   532 GD--DVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQ 594
            |:  |:.:|.|.:.|||.||.|:|.|.|.|....|:|:|..|||.||.||.|....||      :
  Rat   535 GNFSDLHIDLCSIKDRCLPNYCEHGGHCTQTWTSFYCNCSDTGYTGATCHNSIYEQSC------E 593

  Fly   595 HVQQRVN----LNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIM 655
            ..:.|.|    ..:|.||||||.|..|.|....| ::..|:.|:....|.|.|......:..::.
  Rat   594 IYRHRGNKAGFFYVDSDGSGPLGPLQVYCNVTED-KIWMTVQHTITELTQVQGSNSEKPYAMTLN 657

  Fly   656 YDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGS 720
            |..:..|:|||::.|..|.|.::|.||.:.|||:..||    ||:|||.|.|:...||.|.:||.
  Rat   658 YGGSMEQLEALIDGSEHCEQEVTYRCRRAHLFNTQDEA----PFTWWIGRSNERHPYWGGYVPGV 718

  Fly   721 RKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGP 785
            ::|.||:...|.:      ..||:       |.:..|::|||..:...::.....|...|  :||
  Rat   719 QQCGCGLEESCQE------IASNT-------GFLSSKDHLPVTQIIITNSNRTNSEAAWR--IGP 768

  Fly   786 LRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGG 850
            |||.||..|.|.|:|....:.::...|.:..|.||...|:||..:.:.....|...:::|.::..
  Rat   769 LRCYGDRHFWNAVSFSTEASYLHFSAFHVEFSADISFFFKTTALSGIFLENLGIKGFLRLEMSSP 833

  Fly   851 NKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDG--SIKAEVREPPGPVRAL 913
            :::.|....|:.|:.:.|.:.|.||||.||.:..|||.||..|.||.  ..|.||.:....:  |
  Rat   834 SEVIFAIDVGNSPIELLVQSPYPLNDNQWHYIQAERNIKETLLQVDNLPKNKREVSDQSNFL--L 896

  Fly   914 HLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCES--NPCLNNGT 976
            .|:|.|.||.|:..:.|::||||:|.|||:.:||:|.:|. ..|:..||.|.|.|  ..|.|.|.
  Rat   897 QLSSQLFIGGTSSRQKGFLGCIRSLHLNGQKIDLEERAKI-TPGVRPGCPGHCSSYGRNCHNGGK 960

  Fly   977 CIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAEN-------------- 1027
            |:|:::||||||..|.|:||.|..|:.....|.:.:.|.|:..:  .:|:|
  Rat   961 CVEKHNGYSCDCTNSPFEGPFCQKEMSALFYSGTSVTYMFQEPY--PVAKNTSLSSSAIYKDTAP 1023

  Fly  1028 ----IRVGFTTTIPKGFL--LGFSSNLTGEYLTIQISNSGHLRC----------VFDFGFERQEI 1076
                :.:.|.|......|  |.||..   .:|.|.:|.:|.|:.          ||..|.|
  Rat  1024 SKEIVTLSFITAQAPALLLYLKFSPQ---SFLAILLSRNGSLQIHYQLSKVESHVFTVGSE---- 1081

  Fly  1077 IFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK----- 1136
                 :....:.|::: |.:| |..:.::||. :...|||    |.:.:|..::.:.:||
  Rat  1082 -----NLANRRVHEVN-MNRN-GQELSIQVDQ-QLFSYNF----SPEVEFQTVRSLILGKVTETL 1134

  Fly  1137 ------NESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCG--VEPVTHPPI 1193
                  .::.|.|||||:|.||::.|.|||...:......|...|| |||..||  ||...:...
  Rat  1135 VLNPEVTQANTLGFVGCLSSVQYNHIAPLKAALRHASIAPVTVQGT-LTESSCGSMVESYANGVT 1198

  Fly  1194 EIETRPPPL--VDE-EKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTH--- 1252
            .:.:...|.  .|| |.|..|. :.||..:..::.|:..:...:..::..:|::||..:.|:
  Rat  1199 TVYSSSDPFGNTDEHEPLTNAI-QSDSAFIGGVIAIVTFIAFGVIGIMTHFLYQHKQSHHTNPMK 1262

  Fly  1253 EDQGADGADDP--DDAVLHSTTGHQVRKRTEIFI 1284
            |.:..:..|..  :|..|.:|.....|   |.||
  Rat  1263 EKEYPENLDSSFRNDIDLQNTVSDCKR---EYFI 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	43/146 (29%)
		FA58C	57..184	CDD:238014	39/131 (30%)
		LamG	192..340	CDD:238058	51/154 (33%)
		LamG	376..514	CDD:238058	52/153 (34%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	42/120 (35%)
		EGF_CA	966..998	CDD:238011	17/33 (52%)
		Laminin_G_2	1032..1156	CDD:280389	37/146 (25%)
		4.1m	1239..1255	CDD:128590	5/18 (28%)
LOC304725	NP_001316828.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3028
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	603	1.000	Inparanoid score	I905
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm45876
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980