DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Cntnap5a

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_038946578.1	Gene:	Cntnap5a / 297832	RGDID:	1559812	Length:	1306	Species:	Rattus norvegicus

Alignment Length:	1327	Identity:	419/1327 - (31%)
Similarity:	656/1327 - (49%)	Gaps:	153/1327 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GLLCLLL--LVNNGIKSVQADAFTDYFSDYDCNQPLME-RAVLTATSSLTERGP-DKARLN---G 75
            |||.|:|  |.:.|:.:          |:|:|:.||.. .:.:|.:|||...|. ..|:||   |
  Rat     9 GLLTLVLSALWHLGLTA----------SNYNCDDPLASFFSPMTFSSSLDLTGSYSSAQLNWKMG 63

  Fly    76 NAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQ 140
            ...|:||::....:|.:|||:...:..:||.||..:.::||.|.:.:||.|..|:.|   |.|..
  Rat    64 TGGWSPVDSNAQQWLQIDLGNRVEITAVATQGRYGSSDWVTSYRLMFSDTGHNWQHY---TQEDS 125

  Fly   141 M--FKGNSDGNSIHYNVFEVPIIAQWVRINPTRW--HDRISMRVELYGCDYISENLYFNGTGLVR 201
            :  |.||.:.:|:.::.....:.|::||..|..|  :.:|.||||.|||.|.|:...|:|...:.
  Rat   126 IWTFVGNMNADSVVHHRLLHSMRARFVRFVPLEWNPNGKIGMRVEAYGCSYRSDVADFDGRSTLL 190

  Fly   202 YDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDL-GSRVMTSLSV 265
            |...::.:::.|:.|..:||:...:||:.:..|.:||:..|:|:..::.|.|:| .|:...|.:|
  Rat   191 YRFNQKTMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHVTLELQKGRLALYLNLDDSKARLSSTV 255

  Fly   266 -----GSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGL 324
                 ||||||..||.|::.|..:...|:||......:.:||...|:::.||..||:| ..:.|.
  Rat   256 PLVIMGSLLDDQHWHSVLLERVGKQANFTVDMNTQHFQTKGETDALDIDYELSFGGIPVPSKPGT 320

  Fly   325 IVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTF-TTRSSFVRL 388
            .|::||.||:||:|:|..|.|    |..:..:..:::..|..::|..|.|.|:|| .:|||::.|
  Rat   321 FVKKNFHGCMENLYYNGVNII----DLAKRRKHQIYSVGNVTFSCSEPQIVPITFVNSRSSYLML 381

  Fly   389 KGYENSQRLNVSFYFRTYEETGVMLHHDFYSG-GYLKVFLEFGKVKIDLK--------VKDKARI 444
            .|......|:|||.|||:.|.|::|..:...| |.|.:.||.|.:::.:|        :|..:.:
  Rat   382 PGTPQIDGLSVSFQFRTWNEDGLLLSTELSEGSGTLLLILEGGTLRLLIKKVAGHGTEIKTGSGL 446

  Fly   445 ILDNYDDQFNDGKWHSFVISIEKNRLILNIDQ---RPMTTTKSMQVATGAQYYIAGGKDK----- 501
                     |||.|||..|:..:||:.|.:|.   .|...|...|:.:|..||..|..|.
  Rat   447 ---------NDGLWHSVSINARRNRVTLTLDNDAASPAPETSRKQIYSGKSYYFGGCPDNLTDSQ 502

  Fly   502 -----NGFVGCMRLISVDGNYKLPQDWVKGEEVCCGD--DVVVDACQMIDRCNPNPCQHKGLCHQ 559
                 ..|.||||||.:|..   |:|.:..::...|:  |:.:|.|.:.|||.||.|:|.|.|.|
  Rat   503 CLNPIKAFQGCMRLIFIDNQ---PKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGHCAQ 564

  Fly   560 NSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSD 624
            ....|:|:|..|||.||.||.|....||...::..|...  ...:|.||||||.|..|.|....|
  Rat   565 TWTTFYCNCSDTGYTGATCHDSIYEQSCEVYRHKGHTAG--FFYVDSDGSGPLGPLQVYCNITED 627

  Fly   625 GRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNS 689
             ::..|:.|:....|.|.|......:..::.|..:..|:|||::.|..|.|.|.|.||.|||.|:
  Rat   628 -KIWMTVQHNNTELTRVQGSSPEKPYSMTLNYGGSMEQLEALIDGSEYCEQELKYHCRRSRLLNT 691

  Fly   690 PSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDI 754
            ....    ||:|||.|.|:...||.|::||.::|.||:...|.|...:||||::..||..:.|..
  Rat   692 LDGT----PFTWWIGRSNERHPYWEGSVPGVQQCGCGLEESCLDNAYFCNCDADMDEWSNNTGLF 752

  Fly   755 REKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGD 819
            ..|::|||..|...||.....|...|  :|||||.||..|.|.|:|....:.::.|.|....|.|
  Rat   753 SLKDHLPVTHVIITDTNRSNSEAAWR--IGPLRCNGDRHFWNAVSFSTEASYLHFPTFHAEFSAD 815

  Fly   820 IYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSV 884
            |...|:||..:.|.....|..|:::|.::..:::.|....|:||:.:.|.:.|.||||.||.:..
  Rat   816 ISFFFKTTALSGVFLENLGIKDFLRLEMSSPSEVTFTIDVGNGPVELLVQSPYPLNDNQWHYIRA 880

  Fly   885 ERNRKEARLVVDGSIKAEVREPPGPVR-ALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLK 948
            |||.||..|.|| ::...:||...... .|||||.|.:|.|:..:.|::||:|:|.|||:..||.
  Rat   881 ERNVKETSLQVD-NLPLSLREASEEAYFRLHLTSQLFVGGTSSRQKGFLGCMRSLHLNGQNTDLI 944

  Fly   949 EYSKRGLYGISTGCVGRCE--SNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSI 1011
            |.:|. :.|::.||.|.|.  |:.|.|.|.|:|:..||||||..|..:||.|..||.......:.
  Rat   945 ERAKL-MSGVTPGCPGHCSSYSSNCHNGGKCVEKQSGYSCDCTNSPNEGPFCQKEISALFDPGTS 1008

  Fly  1012 IRYEFEGSF------------------RSTIAENIRVGFTTTIPKGFL--LGFSSNLTGEYLTIQ 1056
            :.|.|:..:                  ||  .|.|.:.|.|......|  |.|||.   ::|.|.
  Rat  1009 VTYMFQEPYLVIKNTSLLSSPIYTDTARS--KETIMLNFLTAQAPTILLYLNFSSQ---KFLAIL 1068

  Fly  1057 ISNSGHLRCVFDFG-FERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKA 1120
            :|::|.|:..|... .|........::...|:.|.:...:  .|..:.:::|. :...|||..|
  Rat  1069 LSSNGSLQIRFRLSKGESHVYTMSTENLANGRVHQVKISK--DGPEISIQMDQ-QLFSYNFSTK- 1129

  Fly  1121 SADAQFNNIQYMYIGKNESMTD--------------GFVGCVSRVQFDDIYPLKLMFQQNPPKNV 1171
               .:|..::.:.:||   :|:              ||:||:|.||::.|.|||...:......|
  Rat  1130 ---VEFWTLKSLVLGK---VTETLGLDPEVAKVNILGFLGCLSSVQYNHIAPLKAALRHAGVAPV 1188

  Fly  1172 KSLGTQLTEDFC------GVEPVT--HPPIEIETRPPPLVDEEKLRKAYNEV--DSVLLACLLVI 1226
            ...|| |||..|      .|..||  |..:|      |:...::.....|.|  ||.::..::.:
  Rat  1189 TVHGT-LTESGCDSTLDSDVNAVTTVHSSLE------PIGKRDEQEPLTNTVQSDSAVIGGIIAV 1246

  Fly  1227 LFLLLILMFFLIGRYLHRHKGDYLTHE 1253
            :..:...:..::..:|::||..:.|::
  Rat  1247 VTFVTFCVIGIMICFLYQHKQSHRTNQ 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	48/147 (33%)
		FA58C	57..184	CDD:238014	44/134 (33%)
		LamG	192..340	CDD:238058	50/154 (32%)
		LamG	376..514	CDD:238058	52/160 (33%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	44/119 (37%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	33/140 (24%)
		4.1m	1239..1255	CDD:128590	4/15 (27%)
Cntnap5a	XP_038946578.1	FA58C	42..173	CDD:238014	44/133 (33%)
		Laminin_G_2	209..338	CDD:396680	46/128 (36%)
		LamG	368..520	CDD:238058	52/160 (33%)
		EGF	551..582	CDD:394967	15/30 (50%)
		LamG	793..937	CDD:238058	49/144 (34%)
		EGF	961..>985	CDD:394967	11/23 (48%)
		Laminin_G_2	1045..1173	CDD:396680	33/140 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3028
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	603	1.000	Inparanoid score	I905
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm45876
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980