Protein Alignment Nrx-IV and Cntnap3

DIOPT Version :10

• Sequence 1: NP_524034.2
• Gene: Nrx-IV / 39387
• FlyBaseID: FBgn0013997
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_001389146.1
• Gene: Cntnap3 / 290952
• RGDID: 1563615
• Length: 1288
• Species: Rattus norvegicus
• Alignment Length: 1336
• Identity: 417/1336 - (31%)
• Similarity: 625/1336 - (46%)
• Gaps: 164/1336 - (12%)

  Fly     9 KAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPL---MERAVLTATSSL-TERGPD 69
            |.||  |...||.||||....:..|.|.      ..:||:.||   :.:...:::|.| :..||.
  Rat     5 KGAF--LDVLLLLLLLLSAQTLPLVAAG------DSHDCDAPLASSLPQLSFSSSSQLSSSHGPG 61

  Fly    70 KARLN---GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRS 131
            .||||   |...|||:.:....:|.:|||:...|..:||.|...:.::||.|::.:||.|..|:.
  Rat    62 FARLNRRDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYLLMFSDGGRNWKQ 126

  Fly   132 YVNPTSEPQM--FKGNSDGNSIHYNVFEVPIIAQWVRINPTRWH--DRISMRVELYGCDYISENL 192
            |   ..|..:  |.||::.:|:.....:.....:::|..|..|:  .||.||:|:|||.|.||.:
  Rat   127 Y---HQEESILGFPGNTNADSVVQYSLQPSFHTRFLRFLPLAWNPKGRIGMRIEVYGCSYKSEVV 188

  Fly   193 YFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGS 257
            ||:|...:.|...:..|...:|.|..:||....:|::.:.:|..|::.||:|...|:|:.|..|:
  Rat   189 YFDGRSSLLYKFDKGAIRPIREIISLKFKGMQNSGIIFHGKGRHGNHIALELIKGKLVVYLSSGN 253

  Fly   258 ------RVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGG 316
                  ..:.:.::||||||..||.|:|......:.|::|:......:..|...|:|:.|:..|.
  Rat   254 GNLPPVNSIMNFTLGSLLDDWHWHSVLIEILNYHVNFTLDKYTHHVHVNKESNYLDLDFEISFGE 318

  Fly   317 VPNVQEGLIV---QQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVT 378
            : .:.||.::   .:||.|||||:|:|..|.|::.|..    |..:..:.|..:.||.|...|||
  Rat   319 I-LMPEGHLLTSPHKNFHGCLENVYYNGVNIIKLAKKH----EPQILIKGNVSFTCPQPQTVPVT 378

  Fly   379 FTTRSSFVRLKGYENSQRLNVSFYFRTYEETG-VMLHHDFYSGGYLKVFLEFGKVKIDLKVKDKA 442
            |.:..|::.|.|.....:::::|.|||:.:.| |......:..|.|.:||..||:::.|....:.
  Rat   379 FQSSGSYLALPGSLREDKMSLAFQFRTWNKAGRVFFSQPEHGSGSLVLFLTNGKLRLSLSEPGQP 443

  Fly   443 RIILDNYDD--QFNDGKWHSFVISIEKNRLILNID-----QRPMTTTKSMQVATGAQYYIAGGKD 500
               |.|...  ..|||.|||..::.|...|.|.:|     |..|    |:.:..|..||..|..:
  Rat   444 ---LQNITTGAVLNDGLWHSVSLTAEGRYLSLVVDGDFSAQALM----SVGIHLGDTYYFGGCPN 501

  Fly   501 KN----------GFVGCMRLISVDGNYKLP---QDWVKGEEVCCG-DDVVVDACQMIDRCNPNPC 551
            .:          ||.||:||||:......|   |..|.|     | .|:.:|:|.:||||.||.|
  Rat   502 NSSSSGCESPYGGFQGCLRLISIGDKVVDPIAVQQGVLG-----GFSDLQIDSCGIIDRCLPNYC 561

  Fly   552 QHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNL-NLDVDGSGPLEPF 615
            :|...|.|:...|.|||..|||.|..||:|....||.|.:   |......| .:||||||.|.||
  Rat   562 EHGSGCTQSWDTFSCDCDGTGYTGTTCHSSIYEQSCEAHR---HRGSPSGLYYIDVDGSGQLAPF 623

  Fly   616 PVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYS 680
            .|.|..  .....|.:.|......||.|..|..:...:..|.|...|:.|:::.:..|.|::...
  Rat   624 LVYCNM--TDTAWTVVQHGGPDVMTVRGGPEGHTRSATFSYAATAAQLRAVVDTADHCEQQVDLQ 686

  Fly   681 CRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSL 745
            ||:|    .||:.|:....|||:.|.|:...||.|:||..:||.||:.|.|.|....||||::..
  Rat   687 CRTS----GPSDIGDGTSLSWWVGRTNETYTYWGGSLPDPQKCTCGLEGNCIDSQYHCNCDADRN 747

  Fly   746 EWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLP 810
            ||..|...:..||:|||..:...|||.|..|  ..||||||.|:||..|.|..:|....:.::.|
  Rat   748 EWTSDTIVLSHKEHLPVTEMVVTDTGRPHSE--AAYTLGPLLCQGDKSFWNSASFNTEASYLHFP 810

  Fly   811 PFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLN 875
            .|....:.|::..|:||..:.|.....|.||:|::.|....::.|.:..|:||..:.|.:....|
  Rat   811 TFHGELTADVHFLFKTTISSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCELTVQSLTPFN 875

  Fly   876 DNNWHTVSVERNRKEARLVVDG-SIKAEVREPPGPVRALHLTSDLVIGATTEYRDGYVGCIRALL 939
            ||.||.|..|||.|.|.|.||. ..|.:.....|.|| |.|.|.|.||.|...:.|::||||:|.
  Rat   876 DNRWHHVRAERNVKGASLQVDQLPQKTQPNPADGHVR-LQLNSQLFIGGTASRQKGFLGCIRSLQ 939

  Fly   940 LNGKMVDLKEYSKRGLY--GISTGCVGRCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICAD 1000
            :||..:||:   .|.:.  |:..||.|.|.|  :.|.|.|.|.|:..|.:|||.:||:.||:|:.
  Rat   940 VNGIALDLE---GRAIMTPGVEPGCPGHCSSYGHLCRNGGKCQEKRRGIACDCAFSAYDGPLCSH 1001

  Fly  1001 EIGVNLRSSSIIRYEFE---------GSFRSTI-------AENIRVGFTTTIPKGFLLGFSSNLT 1049
            ||.......|.:.|.|:         .|..|::       .|.|.:.|.||.....|| :.|:..
  Rat  1002 EISAYFEMGSSVTYNFQERPPLDENTSSLASSLHGDVILSRETITLSFRTTQTPCLLL-YVSSFD 1065

  Fly  1050 GEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYE---P 1111
            .|||::.::|:|.|:..:.....|....|   :|.|....|.||.:        |.::..|   .
  Rat  1066 EEYLSVILANNGSLQVRYKLDRHRNADAF---NFDLRNLADGHFHQ--------LMINREEAVVS 1119

  Fly  1112 VEYNFDIK----ASADAQFNNIQYMYIGK-----------NESMTDGFVGCVSRVQFDDIYPLKL 1161
            ||.|...|    .|:..:||.::.:.:||           .::...||.||:|.|||....|||.
  Rat  1120 VEVNQSTKRQVILSSGTEFNAVKSLTLGKVLEPLDVDPETQQAAAQGFTGCLSSVQFGLEVPLKA 1184

  Fly  1162 MFQQNPPKNVKSLGTQLTEDFCGVEPVTH----PPIEI-ETRPPP---------LVDEEKLRKAY 1212
            ...|:.        |::|.. .||....|    |...: :..|.|         :.|.:.|....
  Rat  1185 ALNQDL--------TRVTIQ-GGVTAAAHCAEGPGSAVWKLSPGPSMGAGHSGSVEDRQPLPNTD 1240

  Fly  1213 NEVDSVLLACLLVILFLLLILMFFLI----GRYLHR 1244
            .....|:.....|::|:||......|    .|.||:
  Rat  1241 RSDPGVIGGITAVVIFILLCASAIAIRVHQQRRLHQ 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	57..184	CDD:238014	41/134 (31%)
		LamG	192..340	CDD:238058	46/156 (29%)
		LamG	376..514	CDD:238058	47/155 (30%)
		EGF	546..575	CDD:394967	14/28 (50%)
		LamG	819..943	CDD:214598	47/124 (38%)
		EGF_CA	966..998	CDD:238011	15/33 (45%)
		Laminin_G_2	1032..1156	CDD:460494	38/141 (27%)
		4.1m	1239..1255	CDD:128590	3/6 (50%)
Cntnap3	NP_001389146.1	FA58C	58..180	CDD:238014	39/124 (31%)
		Laminin_G_2	216..346	CDD:460494	40/130 (31%)
		LamG	376..524	CDD:238058	46/154 (30%)
		EGF	556..585	CDD:394967	14/28 (50%)
		GGGWT_bact	596..637	CDD:468872	17/45 (38%)
		LamG	797..941	CDD:238058	49/144 (34%)
		Laminin_G_2	1049..1177	CDD:460494	37/139 (27%)