DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Cntnap3

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001074598.1	Gene:	Cntnap3 / 238680	MGIID:	3588199	Length:	1287	Species:	Mus musculus

Alignment Length:	1322	Identity:	413/1322 - (31%)
Similarity:	624/1322 - (47%)	Gaps:	154/1322 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPL---MERAVLTATSSL-TERGPDKARLN---GN 76
            ||.||||      |||..........::|:.||   :.:...:::|.| :..||..||||   |.
Mouse    12 LLLLLLL------SVQTLPLVAAGDPHNCDAPLASSLPQLSFSSSSQLSSSHGPGFARLNRRDGA 70

  Fly    77 AAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQM 141
            ..|||:.:....:|.:|||:...|..:||.|...:.::||.|::.:||.|..|:.| :.......
Mouse    71 GGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYLLMFSDGGRNWKQY-HQEESISG 134

  Fly   142 FKGNSDGNSIHYNVFEVPIIAQWVRINPTRWH--DRISMRVELYGCDYISENLYFNGTGLVRYDL 204
            |.||::.:|:.....:.....:::|..|..|:  .||.||:|:|||.|.||.:||:|...:.|..
Mouse   135 FPGNTNADSVVQYSLQPSFHTRFLRFLPLTWNPKGRIGMRIEVYGCSYKSEVVYFDGQSSLLYKF 199

  Fly   205 RREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGS------RVMTSL 263
            ....|...:|.|..:||....:|::.:.:|..|.:..|:|...|:|:.|:.|.      ..:.:.
Mouse   200 DNGAIRPVREVISLKFKAMQNSGIIFHGKGQHGTHIVLELNKGKLVVYLNSGDGNLPPVNSIMNF 264

  Fly   264 SVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGV--PNVQEGLIV 326
            ::||||||..||.|:|..:...:.|::|:.:....:..|.:.|:||.|:..|.:  |..:.....
Mouse   265 TLGSLLDDRHWHSVLIELHNMHMNFTLDKYMHHVHVNKETSYLDLNFEISFGEILMPGGRFLTFP 329

  Fly   327 QQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGY 391
            .:||.|||||||:|..|.|::.|..    |..:..:.|..:.||.|...||||.:..|::.|...
Mouse   330 HKNFHGCLENIYYNGVNIIKLAKKH----ESQILIKGNVSFTCPQPQTIPVTFLSSGSYLALPSS 390

  Fly   392 ENSQRLNVSFYFRTYEETGVMLHHDFYS-----GGYLKVFLEFGKVKIDLKVKDK------ARII 445
            ....:::::|..||:.:.|    |.|:|     .|.|.:||:.||:.::|....:      ...:
Mouse   391 LREDKMSLAFQLRTWNKAG----HVFFSQVGHGSGSLVLFLKNGKLILNLSEPGQPLQSITTGAV 451

  Fly   446 LDNYDDQFNDGKWHSFVISIEKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKN-------- 502
            |       |||.|||..:|.:.:.|.|.:|.....|..|:::..|..||..|..:.:
Mouse   452 L-------NDGLWHSVSVSAKGSYLSLLVDGDTAQTLMSVEIHLGDTYYFGGCPNNSSSFGCEHS 509

  Fly   503 --GFVGCMRLISVDGNYKLP---QDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSR 562
              ||.||:|||||......|   |..|.|.    ..|:.:|:|.:||||.|:.|:|...|.|:..
Mouse   510 FGGFQGCLRLISVGDKVVDPIAVQQGVLGS----FSDLQIDSCGIIDRCLPSYCEHGSRCTQSWD 570

  Fly   563 EFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNL-NLDVDGSGPLEPFPVTCEFYSDGR 626
            .|.|||..|||.|..||:|....||.|.:   |......| .:||||||||.||.|.|...:| .
Mouse   571 TFSCDCEGTGYTGTTCHSSIYEQSCEAHR---HRGSPSGLYYIDVDGSGPLAPFLVYCNMTAD-T 631

  Fly   627 VITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPS 691
            ..|.:.|......||.|..|......:..|.||..|:.|::|.:..|.|::...||:|    .||
Mouse   632 AWTVVQHGGPDVVTVRGGPEGHMHSATFSYAANAAQLHAVVNVAEHCEQQVDLQCRTS----GPS 692

  Fly   692 EAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIRE 756
            :.|:....|||:.|.|:...||.|:||..:||.||..|.|.|....||||::..||..|...:..
Mouse   693 DTGDGTSLSWWVGRSNETYTYWGGSLPNPQKCTCGFEGNCIDSQYHCNCDADRNEWTSDTIVLSH 757

  Fly   757 KEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIY 821
            ||:|||..:...|||.|..|  ..||||||.|:||..|.|..:|....:.::.|.|....:.|::
Mouse   758 KEHLPVTEMVVTDTGRPYSE--AAYTLGPLLCQGDKSFWNSASFNTEASYLHFPTFRGELTADVH 820

  Fly   822 LEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVER 886
            ..|:||..:.|.....|.||:|::.|....::.|.:..|:||..:.:.:....|||.||.|..||
Mouse   821 FLFKTTISSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCELTIQSPTPFNDNRWHHVRAER 885

  Fly   887 NRKEARLVVDGSIKAEVREPP--GPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKE 949
            |.|.|.|.|| .:..:.:..|  |.|| |.|.|.|.||.|...:.|::||||:|.:||..:||:|
Mouse   886 NVKGASLQVD-QLPQKTQSTPADGHVR-LQLNSQLFIGGTASRQKGFLGCIRSLQVNGMALDLEE 948

  Fly   950 YSKRGLY--GISTGCVGRCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSS 1010
               |.:.  |:..||.|.|.|  :.|.|.|.|.|::.|.:|||.:||:.||:|:.||.....:.|
Mouse   949 ---RAVMTPGVEPGCSGHCSSYGHLCRNGGMCQEKHRGIACDCAFSAYDGPLCSYEISAYFETGS 1010

  Fly  1011 IIRYEFEGSFRSTIA------------------ENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQI 1057
            .:.|.|:.  .||::                  |.|.:.|.||.....|| :.::...|||:|.:
Mouse  1011 SVTYNFQE--YSTLSANTSYLASSLHGDVILSRETITLSFRTTQTPCLLL-YVTSFYEEYLSIIL 1072

  Fly  1058 SNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHF--MRKNGGSTVVLKVDNYEPVEYNFDIK- 1119
            :|:|.|:..:.....|....|   :|.|....|.||  :..|....||       .||.|...|
Mouse  1073 ANNGSLQVRYKLDRHRNADAF---NFDLRNLADGHFHQLTINREEAVV-------SVEVNQSTKR 1127

  Fly  1120 ---ASADAQFNNIQYMYIGK-----------NESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKN 1170
               .|:..:||.::.:.:||           .::...||.||:|.|:|....|||....||..:
Mouse  1128 QVILSSGTEFNAVKSLVLGKVLEPLDADPETQQAAAQGFTGCLSSVRFGLEVPLKAALNQNRAR- 1191

  Fly  1171 VKSLGTQLTEDFCGVEPVTHPPIEIETRPPPLV---------DEEKLRKAYNEVDSVLLACLLVI 1226
            |...|:......|...|.:   .|.:..|.|.:         |.:.|.........|:.....|:
Mouse  1192 VTIQGSVAAAAHCAEGPGS---AERKLSPGPSMDAGHSGSAEDRQPLPNTDRSDPGVIGGITAVV 1253

  Fly  1227 LFLLLILMFFLI----GRYLHR 1244
            :|:||.:....|    .|.||:
Mouse  1254 IFILLCVSAIAIRVHQQRRLHQ 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	44/147 (30%)
		FA58C	57..184	CDD:238014	40/132 (30%)
		LamG	192..340	CDD:238058	46/155 (30%)
		LamG	376..514	CDD:238058	45/158 (28%)
		EGF	546..575	CDD:278437	13/28 (46%)
		Laminin_G_2	824..943	CDD:280389	45/120 (38%)
		EGF_CA	966..998	CDD:238011	15/33 (45%)
		Laminin_G_2	1032..1156	CDD:280389	38/140 (27%)
		4.1m	1239..1255	CDD:128590	3/6 (50%)
Cntnap3	NP_001074598.1	FA58C	57..179	CDD:238014	38/122 (31%)
		FA58C	58..180	CDD:214572	39/122 (32%)
		LamG	186..343	CDD:238058	46/156 (29%)
		Laminin_G_2	402..525	CDD:280389	39/133 (29%)
		EGF_CA	551..586	CDD:238011	17/34 (50%)
		FReD	593..>638	CDD:294064	19/48 (40%)
		LamG	796..940	CDD:238058	48/145 (33%)
		Laminin_G_2	1048..1176	CDD:280389	37/138 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2736
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I733
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm43791
orthoMCL	1	0.900	-	-		OOG6_101349
Panther	1	1.100	-	-	O	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840