DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and Nrxn1

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_011244620.1	Gene:	Nrxn1 / 18189	MGIID:	1096391	Length:	1516	Species:	Mus musculus

Alignment Length:	1319	Identity:	303/1319 - (22%)
Similarity:	496/1319 - (37%)	Gaps:	372/1319 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 DYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMV 250
            :||:.   |.|:....|||.:.||.|:.:.|...|||...||:|::: |...||..|.||:..:.
Mouse   281 EYIAT---FKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 341

  Fly   251 LNLDLGSRVMTSL--SVGSLLDDNVWHDVVISRNQRD--------IIFSVDRVI-VRGRIQGEFT 304
            |.::|||....:|  .|....:||.||||.::||.|.        :..|||.:: ..|..|.::|
Mouse   342 LVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYT 406

  Fly   305 RLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIY 367
            .|..:...|:||.|:..:  |..|..||.|||:.:.:.:.:....:....:.|:..:.......:
Mouse   407 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAF 471

  Fly   368 ACPS-PPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVML-------HH--------- 415
            .|.: ..:.|:||.|..||:.|..:...:..::||.|||.|..|::|       |.
Mouse   472 KCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMI 536

  Fly   416 --DFYS----GGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWH--SFVISIEKNRLIL 472
              ||::    .|:|.:.|:.|...|.:|...|          :.|||:|:  .|........:.:
Mouse   537 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALQK----------KVNDGEWYHVDFQRDGRSGTISV 591

  Fly   473 NIDQRPMTTTKSMQVATGAQYYIAGGKDKN-----------------GFVGCMRLISVDGNYKLP 520
            |..:.|.|.....::.........||..:|                 |:|||:|.:.:||..|..
Mouse   592 NTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDI 656

  Fly   521 QDWVK-----GEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHT 580
            :...:     |.:..|..:..       ..|..|||::.|:|......:.|||..|||.|..|..
Mouse   657 RQMAEIQSTAGVKPSCSKETA-------KPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCER 714

  Fly   581 SNNPLSC-------LALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSD---GRVITTLSHSQ 635
            ....||.       :.|..|.|.                |...|:..|.|.   |.::.|.|...
Mouse   715 EATVLSYDGSMFMKIQLPVVMHT----------------EAEDVSLRFRSQRAYGILMATTSRDS 763

  Fly   636 EHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSR----LFNSPSEAG-N 695
            ..|..::             .||.::::...|:    |   :..:|.||:    ||     || |
Mouse   764 ADTLRLE-------------LDAGRVKLTVNLD----C---IRINCNSSKGPETLF-----AGYN 803

  Fly   696 FRPFSWWISR-------------HNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEW 747
            .....|...|             ..|.|   .|.:.|                     |...||:
Mouse   804 LNDNEWHTVRVVRRGKSLKLTVDDQQAM---TGQMAG---------------------DHTRLEF 844

  Fly   748 ME-DGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLR------------CEGDDL------ 793
            .. :.|.|.|:.||......|               :|.|:            |:..|:
Mouse   845 HNIETGIITERRYLSSVPSNF---------------IGHLQSLTFNGMAYIDLCKNGDIDYCELN 894

  Fly   794 ----FSNV----VTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGP-TDYIKLSLNG 849
                |.|:    |||:...:.:.|.......|..::.:|:||..:.:|.:.:|. .|:|.:.|..
Mouse   895 ARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVK 959

  Fly   850 GNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLV-VDGSIKAEVREPPGPVRAL 913
            | .|.:.:..|:|...:...::..||||.||.|.:.|:......| :|..|..::   ....|.|
Mouse   960 G-YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQI---TAGARNL 1020

  Fly   914 HLTSDLVIGATTE-----------YRDGYVGCIRALLLNGKMVDL----------------KEYS 951
            .|.|||.||...:           .::|:.||:.::.|||::.||                ....
Mouse  1021 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEVALM 1085

  Fly   952 KRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNL---RSSSIIR 1013
            |..|.|.||    .|:.:.|.|.|.|::::||:||||..::|.||:|.|. |...   :....|.
Mouse  1086 KADLQGPST----TCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDP-GTTYIFSKGGGQIT 1145

  Fly  1014 YEFEGSFR-STIAENIRVGFTTTIPKGFLLGF-SSNLTGEYLTIQISNSGHLRCVFDFGFERQEI 1076
            |::..:.| ||.|:.:.:||:|...:..|:.. ||:..|:||.:.| :.|.:...|:.|.:...|
Mouse  1146 YKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI-HQGKIGVKFNVGTDDIAI 1209

  Fly  1077 IFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEY----NFDIKASADAQ------------ 1125
            .........|:||.:.|.|..|.:|  |:||::..:|.    |.|.:..|.|:
Mouse  1210 EESNAIINDGKYHVVRFTRSGGNAT--LQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVD 1272

  Fly  1126 ------------FNNIQYMYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPK-----NVKS 1173
                        ||:...:.||..| ....|.|.:|.:.::.:..|. |..:|...     ||:.
Mouse  1273 EWLLDKGRQLTIFNSQATIIIGGKE-QGQPFQGQLSGLYYNGLKVLN-MAAENDANIAIVGNVRL 1335

  Fly  1174 LG----------------------------------------------TQLTEDF------C--- 1183
            :|                                              :|.|:|.      |
Mouse  1336 VGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSD 1400

  Fly  1184 --GVEPVTHP-------PIEIETRPPPLVDEEKLRKAYNE---VDSVLLACLLVILFLLLILMFF 1236
              .::| ..|       |..:..|.|.....|.:|::.:.   |..::.|..|.||.||     :
Mouse  1401 DEDIDP-CEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILL-----Y 1459

  Fly  1237 LIGRYLHRHKGDYLTHEDQ 1255
            .:.:|.:|.:|.|  |.|:
Mouse  1460 AMYKYRNRDEGSY--HVDE 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572
		FA58C	57..184	CDD:238014
		LamG	192..340	CDD:238058	54/160 (34%)
		LamG	376..514	CDD:238058	41/178 (23%)
		EGF	546..575	CDD:278437	12/28 (43%)
		Laminin_G_2	824..943	CDD:280389	36/131 (27%)
		EGF_CA	966..998	CDD:238011	14/31 (45%)
		Laminin_G_2	1032..1156	CDD:280389	36/152 (24%)
		4.1m	1239..1255	CDD:128590	5/15 (33%)
Nrxn1	XP_011244620.1	LamG	30..190	CDD:238058
		LamG	307..446	CDD:214598	46/139 (33%)
		LamG	503..652	CDD:214598	35/158 (22%)
		EGF_CA	680..713	CDD:238011	13/32 (41%)
		Laminin_G_2	746..874	CDD:366983	35/191 (18%)
		Laminin_G_2	933..1058	CDD:366983	34/128 (27%)
		LamG	1134..>1253	CDD:238058	32/121 (26%)
		Syndecan	1441..>1480	CDD:366429	13/43 (30%)
		4.1m	1461..1479	CDD:128590	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910