DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and nrx-1

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001263859.1	Gene:	nrx-1 / 179503	WormBaseID:	WBGene00007799	Length:	1725	Species:	Caenorhabditis elegans

Alignment Length:	1222	Identity:	254/1222 - (20%)
Similarity:	446/1222 - (36%)	Gaps:	293/1222 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 WRSYVNPTSEPQMFK--GNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYG------C 185
            :|.|....:.||:.:  |.......|.....:....|:|.:|..          |.|.      |
Worm   197 YRQYPQGVTSPQLLESVGTRTNEDDHCKSKSMSSREQFVCLNDG----------ECYSSNDGPHC 251

  Fly   186 D-----------YISEN---LYFNGTGLVRYDLR---REPITSTKESIRFRFKTAFANGVMMYSR 233
            |           .|.:|   |.|.|...|.||:.   ...:.:.||::...|||.....::.|:
Worm   252 DCQFSDHDGRNCEIEKNDGELTFGGDEWVGYDVSLNISAAVRAKKENLTLTFKTVHGTSMLFYA- 315

  Fly   234 GTQGDYYALQLKDNKMVLNLDL-GS-----RVMTSLSVGSLLDDNVWHDVVISR----NQRDIIF 288
            |.:..|..:.|:|..::.:... ||     |:..|.. ....||:.||.:::.|    :..:::.
Worm   316 GDEKSYLHVMLQDGAIIASSKFDGSDARIIRMFNSFP-SQRYDDDSWHTIILERSLQMHSEEMVA 379

  Fly   289 SVDRVIVRGR-------------IQGEFTRLNLNRELYLGGVPNVQEGLIVQQ-NFSGCLENIYF 339
            ....:||.||             |...|.        :||.:|.......|.: :|.||::.:.:
Worm   380 IHMTLIVDGRRDEIRQYAPELDWISNSFG--------FLGSIPKHNPSKEVNRVSFRGCMKKVRY 436

  Fly   340 --NSTNFIRVMKDSTELGEGYLFTRVNTIYAC--PSPPIYPVTFTTRSSFVRLKGYENSQRLNVS 400
              ::|..:.|.......|...:.|..:..|:|  ||.....::||..||::.|..:.:....::|
Worm   437 DIDATRILLVNLADQSYGGSVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLS 501

  Fly   401 FYFRTYEETGVMLHH--------DFYS----GGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQF 453
            |:|||....|::|:|        |:.:    ..:|.:.:..|...:.|:....          :.
Worm   502 FHFRTTSSDGLILYHGVMQHNATDYVAFELIDSHLFMIINLGSGVVRLQTTSM----------KV 556

  Fly   454 NDGKWH-----------SFVIS----------------IEKNRLILNIDQRPMTTTKSMQVATGA 491
            :||:||           |.::.                |:....|.|:....:....|:
Worm   557 SDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSV------ 615

  Fly   492 QYYIAGGKDKNGFVGCMRLISVDG-NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKG 555
             :.||..|   |:.||::.|.::| :.|:.|::......  |.::.......:|.|.|||||:.|
Worm   616 -WSIALQK---GYTGCIKNIRMNGVSTKIGQEFEASNST--GIELGCSLSNELDICEPNPCQNFG 674

  Fly   556 LCHQNSREFFCDCGHTGYAGAVCHTSN------------NPLSCLALKNVQHVQQRVNLN----- 603
            .|.:|...|.|||.:|.:.|..|....            :.|:...:..|:|::.|....
Worm   675 KCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHVLAHTKVSQVEHIKIRFRTTSSRGV 739

  Fly   604 -LDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDA-NQLQIEAL 666
             .|...:|..:...|   |.:|.::...|..|..:.|.        |:.:|:..:. ::||:..|
Worm   740 LFDTGANGKNDKITV---FLNDSQLNLFLQDSSTNNTF--------SWGKSLSDNHWHELQVRRL 793

  Fly   667 LNR---------SHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRK 722
            ..:         |||.:.:                    .|.|..|..........:.|.|...:
Worm   794 GQKLLLYLDGFWSHSIYLQ--------------------NPISVEIDEVGAAFSVHSSAPPPRDE 838

  Fly   723 CECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLR 787
            ...|.|.|.                :.:|.|...|..:         ....|.:...|.:.|.
Worm   839 HFKGFLSKL----------------VFNGNDYLAKTKM---------NSAQLSKSSSRESKGQ-- 876

  Fly   788 CEGDDLFSNVVTFRIADASINLPPFDMGHSGD----------IYLEFRTTQENSVIFHATGPTDY 842
                   .||.| |||..|.......:..|.|          :..:|:|...::::|......||
Worm   877 -------RNVKT-RIASISFTNSTGYVAFSSDKISGLTGSFRVQFKFQTLMRSALLFFTLPKHDY 933

  Fly   843 ---IKLS-LNGGNKLQFQYQAGSGPLGVNVGTS-------YHLNDNNWHTVSVERNRK--EARLV 894
               .:|. |||  :|::.|:..    |....|:       .||:|..||.|.:.::.|  :..|:
Worm   934 DQSFRLQMLNG--RLKYTYRTS----GQEFHTTSPKLPHRQHLSDMRWHNVLIYQDEKTHDHVLL 992

  Fly   895 VDGSIKAEVREPPGPVRALHLTSDLVIGA----TTEYRDGYVGCIRALLLNGKMVDLKEYSKRGL 955
            ||.|....:.:....|.: .::..|..|:    .:...:|:.|||..|.:|...:||.|.:...:
Worm   993 VDNSSTTLIIDKIKKVES-KMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRM 1056

  Fly   956 YGISTGCVG---RCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLR---SSSIIRY 1014
             .::.||.|   ||..:.|.|:|.||:.:....|||..:|..|..|.:. ...:|   |.|.|.|
Worm  1057 -KVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNP-STTVRFDGSPSAIFY 1119

  Fly  1015 EFEGSFRSTIAENIRV-GFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIF 1078
            |:..:.|.|.:::..| .|.||.|.|.|:........:|.||.: |.|:|...::.|.......:
Worm  1120 EYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQDYFTIFL-NKGYLNAHYNLGNRDHTTSY 1183

  Fly  1079 PKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEY-----------NFDIKASADAQFN----- 1127
            ..:....|..|.:...|.....|:  :||....:.|           |...:.|..|.||
Worm  1184 HTRILNDGFPHVIKISRTEANMTI--QVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLD 1246

  Fly  1128 NIQYMYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLT 1179
            ..:.:...:|..:.|.:.|.:|.|..:.:..|.|  .:|....:.::|...|
Worm  1247 QKRLLRHRRNTEIFDSYQGEISGVNVNGLMILDL--YENGSNRIHTIGAPQT 1296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	11/63 (17%)
		FA58C	57..184	CDD:238014	10/56 (18%)
		LamG	192..340	CDD:238058	38/176 (22%)
		LamG	376..514	CDD:238058	33/176 (19%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	33/135 (24%)
		EGF_CA	966..998	CDD:238011	11/31 (35%)
		Laminin_G_2	1032..1156	CDD:280389	30/139 (22%)
		4.1m	1239..1255	CDD:128590
nrx-1	NP_001263859.1	LamG	36..180	CDD:238058
		Laminin_G_2	303..437	CDD:280389	30/143 (21%)
		LamG	477..634	CDD:238058	33/176 (19%)
		EGF_CA	663..698	CDD:238011	16/34 (47%)
		Laminin_G_2	731..852	CDD:280389	24/167 (14%)
		LamG	885..1042	CDD:238058	35/163 (21%)
		Laminin_G_2	1138..1274	CDD:280389	30/138 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910