DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrx-IV and nlr-1

DIOPT Version :9

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:NP_502312.2 Gene:nlr-1 / 178167 WormBaseID:WBGene00003772 Length:1180 Species:Caenorhabditis elegans


Alignment Length:1260 Identity:314/1260 - (24%)
Similarity:521/1260 - (41%) Gaps:229/1260 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 RMHTDEFVTEYIVQYS---DDGEFWRSYVNPTSEPQMFKGNSDGNS-IHYNVF-------EVPII 161
            |:.....::.|.|:.|   ||.:..|.              |:||. :.|:..       .|..:
 Worm    42 RLSVSGHISAYHVKVSISDDDFQLVRL--------------SNGNPLVLYSTLSNTPSWTHVDFL 92

  Fly   162 AQWVRINPTRWHDRISMR---VELYGCDYISENLYFNGTGLVRYDLRREPITSTKES---IRFRF 220
            |..|||.|........:|   :.|..|||.:....|:.:... .:.....:.|..|:   :.|| 
 Worm    93 ATEVRIFPAFEQATEDVRGPLLILTICDYDTPITAFDDSSYT-VEAHHAGLVSMYENDLCVVFR- 155

  Fly   221 KTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRD 285
              .:.:||..:|...|||....|:....:.:..|.||...:.:|.|..|||..||::........
 Worm   156 --TYRSGVFFFSMADQGDVLIAQIIHGTVHVIFDFGSLTPSRISAGKALDDGRWHEMRWLHQFDS 218

  Fly   286 IIFSVDRVIVRGRI-QGEFTRLNLNRELYLGGVPNVQEGLIVQQNFSGCLENIYFNSTNFIRVMK 349
            :..|:|.|::.... .|.:.:|:|:..:::||.||......::..|:||:..:..|:.:.:::..
 Worm   219 VQLSIDGVLLNQTAPTGLYRKLDLHSVVHIGGRPNDDFSQGIETTFTGCIARLQLNNADLLQLSP 283

  Fly   350 DSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQR-------LNVSFYFRTYE 407
            :           .|:.....|.||    :||          ..||.|       |..||.||...
 Worm   284 N-----------EVHNQCQMPKPP----SFT----------LHNSSRAVLPFTFLPFSFEFRIVP 323

  Fly   408 ETGVMLH-HDFYSGGYLKVFLEFGKVKIDL-----KVKDKARIILDNYDDQFNDGKWHSFVISIE 466
            ..|.::. .|..:|..:.|.:: .:.|:.|     |.|..|...:|     ..||.||||.:.|.
 Worm   324 INGPLVTLFDAENGTLVDVVID-EESKLHLVSNITKFKQAANPAID-----VADGAWHSFSLRIR 382

  Fly   467 KNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKNGFV----GCMRLIS-------VDGNYKLP 520
            ..|:.::||...:...:..:|...:|..       :.|:    ||.|.::       ||||.   
 Worm   383 GVRMEIDIDGYTVLWLEGHEVRRVSQRL-------SNFILSASGCYRSVTIDLTSVRVDGNV--- 437

  Fly   521 QDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNS-REFFCDCGHTGYAGAVCHTSNNP 584
               .:||            |...::|.||||::.|.|.|:: .::.|:| ..||.|..|||::.|
 Worm   438 ---TRGE------------CTFQEKCLPNPCENGGGCVQSALDDYVCNC-KEGYKGKNCHTTDLP 486

  Fly   585 LSC----LALKNVQHVQQRVNLNLDVDGSGPLEPFPVTC-----EFYSDGRVITTLSHSQEHTTT 640
            .||    ....|.|...|...:.:|:||.|.::|..|||     |...|| |.|.|.|.......
 Worm   487 HSCEEWVFTKGNKQKAVQGRKVLIDIDGGGEMQPINVTCKTERDEIGIDG-VSTILEHDLLRPMI 550

  Fly   641 VDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCR-SSRLFNSPSEAGNFRPFSWWIS 704
            |.|..:||:...|:.|..:..|::.|:....:|.|.:.|:|| .:||.....|..   |.||:.:
 Worm   551 VTGDNKPGAVRYSLTYGISTEQMDRLVEGFEACSQFMRYTCRGGARLMTQGDERS---PSSWYST 612

  Fly   705 RHNQPMDYWAGALPGSRKCECGILGKC-HDPTKWCNCDSNSLEWMEDGGDIREKEY---LPVRAV 765
            |.::....|..|.|.||.|.|.|.|.| |:  :.|||||.     ||..|.....|   |||..:
 Worm   613 RSDKHGLQWGEAPPYSRMCSCAINGSCLHN--RMCNCDSG-----EDSTDEGVNPYSQLLPVTGL 670

  Fly   766 KFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASI------NLPPFDMGHSGDIYLEF 824
            ..|  ||.....: ...:|||:|.....| :.|||...:|.:      |...||:    .::::|
 Worm   671 FLG--GTTKSSSI-EVEIGPLKCRNRATF-DPVTFSNRNAKLSGAQTFNQRTFDV----SLHVKF 727

  Fly   825 RTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRK 889
            ..:|.:.:.:|:|....:..|.:|.|   :...:..:|.....:.:.:..:|..:|.:..|.:..
 Worm   728 SHSQMSILSWHSTDDLHWFHLYVNDG---KIVGEVVNGGESQQIVSEHRYDDGKFHAIYWEADST 789

  Fly   890 EARLVVDGSIKAEVREPPGPVRALHLTSDL---VIGATTEY-RDGYVGCIRALLLNGKMVDLKEY 950
            ...|.|||..|:        |:...:...:   ::|:.||. ..|:.|.||.:.|.|..:.|.:|
 Worm   790 GMFLKVDGQRKS--------VKTSFILPTVYMWIVGSRTEKGSTGFAGVIRNVHLCGVELALGQY 846

  Fly   951 SKRGL-YGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRY 1014
            :::.. .|::.|..|.|..:.|.|.|.|:::||||.|||..:.|.|..|..|.|:.:.:.|.|:.
 Worm   847 ARKETERGVAIGDDGYCRPDLCQNGGQCVDKYDGYVCDCSMTPFGGSDCTKEYGMMVPAGSSIQI 911

  Fly  1015 EFEGSFRSTIAENIRVGFT---TTI--PKGFLLGFSSNLTGEYLTIQISNSGHLRCV----FDFG 1070
            .::......:...|.:..|   |||  .|......:.|:|       :.::|:|:.:    |.|.
 Worm   912 PWQNPAHQAMCHRIAIQTTSRNTTILRSKALFADSTFNMT-------VDDNGNLQMMAYDGFFFH 969

  Fly  1071 FERQEIIFPKKHFGLGQ--YHDMHFMRKNGGSTVVLKVDNYE--PVEYNFDIKASADAQFNNIQY 1131
            |:||.    |:| .|..  .||:.|........|  .||..:  .:|.|:....|    ||...:
 Worm   970 FKRQS----KRH-NLSDDIMHDISFCASKHHFNV--SVDGMQVITIEGNWTFFES----FNVWHF 1023

  Fly  1132 MYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIE 1196
                    :.:.|.|||||:|....:|||     ||.....:...::....|.:|.|:...:...
 Worm  1024 --------LDENFEGCVSRIQTGSAFPLK-----NPKTARLNYSGKIRFGTCPIEAVSRQQMYDF 1075

  Fly  1197 TRPPPLV---------DEEKLRKAYNEVDSVLLACL---LVILFLLLILMFFLIGRYLHRHKGDY 1249
            ...|.|:         |.:....:.|:.|.|..|.:   ::.|.|.::.|..||.....|.:|.|
 Worm  1076 NPQPDLISSTIKTSTEDIKIFSVSQNKQDLVSKAIIGGGILALSLFILCMSSLICYMRSRPEGVY 1140

  Fly  1250 LTHEDQGADGADDPDDAVLHSTTGH 1274
            .|:|..........::.::|:||.:
 Worm  1141 KTNETGENCSPSRSEEPLVHNTTSN 1165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572 19/90 (21%)
FA58C 57..184 CDD:238014 19/89 (21%)
LamG 192..340 CDD:238058 35/151 (23%)
LamG 376..514 CDD:238058 36/161 (22%)
EGF 546..575 CDD:278437 12/29 (41%)
Laminin_G_2 824..943 CDD:280389 25/122 (20%)
EGF_CA 966..998 CDD:238011 14/31 (45%)
Laminin_G_2 1032..1156 CDD:280389 35/136 (26%)
4.1m 1239..1255 CDD:128590 5/15 (33%)
nlr-1NP_502312.2 Laminin_G_2 154..275 CDD:280389 32/123 (26%)
EGF 448..479 CDD:278437 13/31 (42%)
LamG 717..836 CDD:238058 26/133 (20%)
EGF_CA 865..896 CDD:238011 13/30 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 97 1.000 Domainoid score I4538
eggNOG 1 0.900 - - E1_KOG3516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 266 1.000 Inparanoid score I1871
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48725
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 1 1.000 - - FOG0000323
OrthoInspector 1 1.000 - - oto20717
orthoMCL 1 0.900 - - OOG6_101349
Panther 1 1.100 - - LDO PTHR15036
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3775
SonicParanoid 1 1.000 - - X247
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.910

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