DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-IV and itx-1

DIOPT Version :9

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:NP_001249244.2 Gene:itx-1 / 171846 WormBaseID:WBGene00002174 Length:1645 Species:Caenorhabditis elegans


Alignment Length:1246 Identity:270/1246 - (21%)
Similarity:448/1246 - (35%) Gaps:353/1246 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 IATMGRMHTDEFVTEYI-VQYSDDGEFWRSYVNPTSEPQMFKGNSDGN----------SIHY-NV 155
            :.|:....|||...|.| ::|..      |:||.||:  .:|.....|          |.|. .:
 Worm    11 LLTVSGQSTDEISHERIFLKYPS------SFVNFTSD--NWKLTETDNQLIIAVKFQASSHIGQI 67

  Fly   156 FEVPIIAQWVRINPTRWHDRISMRVEL---YGCDYISENLYFN-GTGLVRYDLRREPITSTKESI 216
            |.|..      |||..     |::..|   .....:..|||.: .|.::...:...||...:.|:
 Worm    68 FSVRF------INPDG-----SLKALLTAGIAAGILQINLYDDKNTKILNKPMENSPINVHEHSL 121

  Fly   217 RFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISR 281
            .....|...|  :.|..|...|            ||.::...:..|         |....|.|..
 Worm   122 AVGLNTTARN--LWYKLGADND------------LNCEINQAIDIS---------NTEVTVTIGG 163

  Fly   282 NQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGLIVQQNFSGC--LENIYFNSTNF 344
            ..:.:|..|..|.|..   ||.:.::       .|.|      |..|:...|  .:.......|.
 Worm   164 GSQSMIGCVSIVAVSA---GESSPVS-------QGTP------IAYQDIDECPKADACTTKDCNT 212

  Fly   345 IRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTR--------SSFVRLKGYE---NSQRLN 398
            .|.::......:.|     .|..|.|:..:...|...|        |:::|.|.:|   :..||:
 Worm   213 GRCIQLEVPTCDCY-----GTEMAGPNCRLPAPTIQLRNNDENEESSAYLRYKPWEMDSHFSRLS 272

  Fly   399 VSFYFRTYE-ETGVMLHHDFYSGGYLKVFLEFGKVKIDLKVKDKARIILD-----NYDDQFNDGK 457
            :.|.|...: :.|::::.:...|...|:::          |..|.:::||     :::.:.:...
 Worm   273 MDFRFSDSDAKEGILVYGETSQGKIFKIYV----------VGTKGKVMLDTTNVADFELREDHSI 327

  Fly   458 WHSFVISI-------------------EKNRLILNIDQ--RPMTT----------TKSMQV---- 487
            :||.::.|                   |.:.|:.:..|  .|:.|          .|::.|    
 Worm   328 FHSIIVKIVDGIFNMLVDDNVHRRAFNESDALVFDTIQFGAPIPTDVSEVGVTACVKNVYVDHVD 392

  Fly   488 ------------ATGAQYYIAGGKDKNGFVGCMRLISVDGNYKL----PQDWVKGE--EVCCGDD 534
                        .|.::......:|...|.| ..|.|.|...::    |.| :|.|  |...|.|
 Worm   393 IIELAVLTNDSRTTASRVRSCNNEDLTEFQG-PSLFSADPLAEILVEDPSD-IKSEFGESVIGAD 455

  Fly   535 VV------------VDACQMIDRCNPNPCQHKGLCHQNSR-EFFCDCGHTGYAGAVCHTSNNPLS 586
            :.            :.:|   ::.|...||:...|.:.|. ||.|.| ..||.|..|..:..|.|
 Worm   456 MFPVPSNKKPKTQPLSSC---EKANAYMCQNGAGCKKESETEFTCFC-KEGYIGKFCQFTTIPRS 516

  Fly   587 CLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFE 651
            |....:...:...... :||||:..|:|....|   :||:  |.:.|.          .:||...
 Worm   517 CAEAYDFLKLPNGATW-VDVDGNRKLDPSVTMC---TDGQ--TEIPHD----------MKPGYVV 565

  Fly   652 QSIMY-----------DANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWW--- 702
            :...|           |.|..|:...:..|.||.|.::|.|..:.|        .|:....|   
 Worm   566 RDTTYQNHSLFVLSYRDFNSWQLAKYIKNSGSCSQTVNYRCNKAPL--------RFKEGKTWFKS 622

  Fly   703 ISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKF 767
            :|...:.:.. .|.||.|  |.|...| |....| |||||.::.  ||.|::..: |..:..|. 
 Worm   623 VSNATEKIKQ-IGMLPNS--CPCLDRG-CQSGEK-CNCDSGAIS--EDIGELTGR-YSGICEVV- 678

  Fly   768 GDTGTPLDEK--MGRYTLGPLRCEGDD-----LFSNVVTFRIADASINLPPFDMGHSGDIYLEFR 825
                |..||.  ....|:..|:|.|.:     .|:.....:|:|.:        |.|.|  |:||
 Worm   679 ----TLFDEADVRAEMTISELKCSGYENEKPIRFTERTELKISDWT--------GESID--LQFR 729

  Fly   826 TTQENSVIFHATGPTDY----IKLSLNGGNKLQF-QYQAGSGPLGVNVGTSYHLNDNNWHTVSVE 885
            ||:..:.:....|  :|    |.:||..|:.:|. .::|    |.: :.:...|||:|||.|.:|
 Worm   730 TTETPASLVTVQG--NYGEKIISVSLTDGHTVQISNFEA----LKI-IESQTKLNDSNWHHVLIE 787

  Fly   886 RNRKEARLVVDGSIKAEVREPPGPVRALH----------LTSDLVIGATTEYRDGYVGCIRALLL 940
            ....|.|:.||               |.|          |...:|:|..   .||.:||:|.:|:
 Worm   788 LADGEIRVTVD---------------ATHVLMTIGDNAVLEGSVVLGGE---GDGLIGCVRNVLI 834

  Fly   941 NGKMVDLKEYSKRG-LYGISTGCVGRCESNPCLNNGTCIERY-DGYS-CDCRW-SAFKGPICADE 1001
            |.:.|:|:|..|.. ..||:..|..||.::.|.|...|.|.: .|.. |.|.: ....|..|  |
 Worm   835 NDEPVNLQEIVKTSEKTGITETCDTRCTADFCQNGAKCYEDFVSGMPFCQCAFPDVHSGVNC--E 897

  Fly  1002 IGVNLRSSSIIRYEFEGSF------RSTIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNS 1060
            |.:|..||    ..|.|.:      ::.:...|...|.|..... ||.|:.:....:|.:.:|..
 Worm   898 IDINTNSS----VSFHGGYLKFDDVKNVLNAPIYFSFRTDRTHA-LLFFAHDQNNNFLQVHLSEE 957

  Fly  1061 GHLRCVFDFGFERQEIIF-------PKKHFGLGQYHDMHFMR---KNGGSTVVLKVDNYE----- 1110
            .::....:    ..:|:.       |...:|     ||.:::   .:...:..|:||:..     
 Worm   958 VNVTLTLN----NLDIVSQCTVRAQPGTEYG-----DMRWIQVAITHDSKSSQLQVDDAACTIRT 1013

  Fly  1111 -------PVE-----YNFD-----IKASADAQFNNIQYMYIG--KNESMTDG----FVGCVSRVQ 1152
                   |:.     ||.:     :..:|..:.|...:.:||  .....|:|    |..|:.|.:
 Worm  1014 SRVLSEIPITRLLDVYNSELVGMPVGLAAPVKPNPYTFTFIGNVNTGEKTNGKRLLFSDCLPRRR 1078

  Fly  1153 FDDIYPLKLMF 1163
            ...|: |.|:|
 Worm  1079 SPSIF-LMLIF 1088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572 23/96 (24%)
FA58C 57..184 CDD:238014 23/95 (24%)
LamG 192..340 CDD:238058 28/150 (19%)
LamG 376..514 CDD:238058 33/201 (16%)
EGF 546..575 CDD:278437 11/29 (38%)
Laminin_G_2 824..943 CDD:280389 37/133 (28%)
EGF_CA 966..998 CDD:238011 9/34 (26%)
Laminin_G_2 1032..1156 CDD:280389 27/161 (17%)
4.1m 1239..1255 CDD:128590
itx-1NP_001249244.2 LamG 254..389 CDD:238058 24/144 (17%)
EGF 481..507 CDD:278437 11/26 (42%)
LamG 705..835 CDD:238058 43/164 (26%)
LamG 905..1052 CDD:238058 24/160 (15%)
LamG <1268..1364 CDD:304605
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.020

Return to query results.
Submit another query.