DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and cntnap5

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_031749305.1	Gene:	cntnap5 / 101730316	XenbaseID:	XB-GENE-6031102	Length:	1307	Species:	Xenopus tropicalis

Alignment Length:	1274	Identity:	415/1274 - (32%)
Similarity:	644/1274 - (50%)	Gaps:	101/1274 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SDYDCNQPLMERAVLTATSSLTE----RGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMV 100
            :.|:|:.||.......|..|.:|    ||  .|:||   |...|||:|:....:|.:|||:...:
Frog    25 ASYNCDDPLASPLPAPAFDSSSELFGSRG--DAKLNSREGAGGWTPLESNTRQWLQIDLGERFDI 87

  Fly   101 RKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWV 165
            ..:||.||..:.::|..|.:.:||.|..||.| :..:....|.||::.:.:..:.|:..|.|:::
Frog    88 TGVATQGRYGSSDWVMSYSLMFSDTGRNWRPY-HQDNNIWAFAGNTNADGVVQHKFQHSIKARFL 151

  Fly   166 RINPTRWH--DRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGV 228
            |..||.|:  .||.||||:|||.|.|:.:.|:|...::|...::.:|:.|:.|..:||:..::||
Frog   152 RFVPTEWNLVGRIGMRVEVYGCPYKSDVVDFDGRSSLQYRFNQKQMTTFKDVISLKFKSMQSDGV 216

  Fly   229 MMYSRGTQGDYYALQLKDNKMVLNLDLGSRVM------TSLSVGSLLDDNVWHDVVISRNQRDII 287
            :.:..|.:|||..|:|:..|:.|.::||...:      |.:::||||||..||.|:|.|..:.:.
Frog   217 LFHGEGQRGDYITLELQKGKLSLYINLGDTKLRFGNTHTVVTLGSLLDDQQWHSVLIDRFNKQVN 281

  Fly   288 FSVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDS 351
            |:||:.....|.:|:...|:::.|...||:| ..:.|..:::||.||:||:|:|..|.|    |.
Frog   282 FTVDKHTQHFRTKGDSDNLDIDYEFSFGGIPVPGKPGTFLKRNFHGCIENLYYNGVNII----DL 342

  Fly   352 TELGEGYLFTRVNTIYACPSPPIYPVTFTTRS-SFVRLKGYENSQRLNVSFYFRTYEETGVMLHH 415
            .:..:..:|...|..::|..|.:.|||||..| |::.|.|.......:|||.|||:...|::|..
Frog   343 AKRRKPQIFIVGNVTFSCSEPHVIPVTFTNSSTSYLLLPGTPQMDGFSVSFEFRTWNGNGLLLTT 407

  Fly   416 DFYSGGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNID---QR 477
            .| |||...:.|:....|:.|::::...|:..:.....|||.||:..|:..::||.|.:|   ..
Frog   408 QF-SGGSGVLLLQLVSGKLLLEIQEGEHILTLSSGSGLNDGLWHAVTINARRHRLTLTLDNAGSS 471

  Fly   478 PMTTTKSMQVATGAQYYIAGGKDK----------NGFVGCMRLISVDGNYKLPQDWVKGEEVCCG 532
            |.....|..|.:|::||..|..|.          ..|.|||||:.:|..   |:|.:..:....|
Frog   472 PDHLAVSAAVFSGSRYYFGGCPDHLTDSHCIHPVPSFQGCMRLLFIDNQ---PKDLISVQRGLIG 533

  Fly   533 D--DVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQH 595
            :  :|.:|.|.:.|||.||.|||.|.|.|:...|:||||.|||..|.||:|....||.||::...
Frog   534 NYSEVQIDTCGIRDRCLPNYCQHGGECSQSWNAFYCDCGATGYGEATCHSSLYQDSCEALRHRGF 598

  Fly   596 VQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQ 660
            ...  ..::|.||||||.|..|.|....| ::.|.:.|:....|.|.|......:.....|::..
Frog   599 ASD--YYHIDPDGSGPLGPLRVFCNITED-KIWTLVPHNNTELTPVHGNFGVRPYAMLFNYNSTM 660

  Fly   661 LQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCEC 725
            .|:||::||:..|.|.::|.|:.|||.|||:.|    ||:|||.|..:...||.|:|||.:||.|
Frog   661 EQLEAMINRAEYCEQEVAYHCKHSRLLNSPNGA----PFTWWIGRGTERHTYWGGSLPGVQKCAC 721

  Fly   726 GILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEG 790
            |:...|.|...:||||::..||..|.|.:..|::|||..:...|......|...|  :|||||.|
Frog   722 GLEESCIDMRHFCNCDADKHEWTNDTGFLNFKDHLPVSQIVITDANRTGSEAAWR--IGPLRCYG 784

  Fly   791 DDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQF 855
            |..|.|.|:|..|.:.:..|.|....|.|:...|:||..:.|.....|..|::::.|....::.|
Frog   785 DRSFWNAVSFNTASSFLPFPIFHPEFSADVSFFFKTTSASGVFLENLGVKDFMRIELISPYQVIF 849

  Fly   856 QYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREP-PGPVRALHLTSDL 919
            .:.|||||..|.:.:...|||..||.|..|||.|||.|:||...|...||. .|.:| |.|:|.|
Frog   850 SFDAGSGPTEVLLHSVSALNDGQWHYVKAERNMKEATLIVDNQPKRLAREALDGRIR-LPLSSQL 913

  Fly   920 VIGATTEYRD-GYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCES--NPCLNNGTCIERY 981
            .:|.|...|. |:|||||:|..||:|:||||.: |....|..||.|.|.:  :.|.|||.|:|:.
Frog   914 YVGGTLSNRQRGFVGCIRSLQFNGQMIDLKERA-RLTPDIRPGCPGHCGTYGHLCRNNGKCVEKR 977

  Fly   982 DGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFE---------GSFRST--------IAENIR 1029
            :||.|||..||::||.|..|:.....:.:.:.|.|:         .:|.|:        ..|||.
Frog   978 NGYFCDCTNSAYEGPSCVKEVSAMFEAGTSVTYIFQEPYPVSKNASNFPSSPIYADTVISKENIS 1042

  Fly  1030 VGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFM 1094
            ..|.|......||..:| ...:||.:.:..:|.|:..:....|..: :|..:...|......|..
Frog  1043 FSFVTGQAPSLLLHINS-FYHDYLAVLLIKNGSLQVRYKVSKEGTQ-VFTLESERLDNRRPHHVR 1105

  Fly  1095 RKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK-----------NESMTDGFVGCV 1148
            ....|..:::::|......:||    |:|..|..|:.:.:||           .::.|.|||||:
Frog  1106 ISREGRELIIQIDKMIKQRHNF----SSDIYFKAIKSLTLGKVVDNPGLDSEVAKANTFGFVGCL 1166

  Fly  1149 SRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIET----RPPPLVDEEKLR 1209
            |.||::.:.|||...:......|...|| |:|..||  .||...:...|    ...|...::...
Frog  1167 SSVQYNHVAPLKAALRHPSIAPVTVTGT-LSECSCG--SVTESDLSTVTTTYSSSGPFGKDDDRE 1228

  Fly  1210 KAYNEV--DSVLLACLLVILFLLLILMFFLIGRYLHRHK 1246
            ...|.|  ||.::..::.:...::..:..::.:.|::||
Frog  1229 PITNAVRSDSAVIGGVIAVTVFIIFCIVAIMTKILYQHK 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	49/147 (33%)
		FA58C	57..184	CDD:238014	45/135 (33%)
		LamG	192..340	CDD:238058	50/154 (32%)
		LamG	376..514	CDD:238058	49/151 (32%)
		EGF	546..575	CDD:278437	17/28 (61%)
		Laminin_G_2	824..943	CDD:280389	49/120 (41%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	32/134 (24%)
		4.1m	1239..1255	CDD:128590	3/8 (38%)
cntnap5	XP_031749305.1	FA58C	44..172	CDD:238014	44/130 (34%)
		Laminin_G_2	208..337	CDD:396680	45/128 (35%)
		LamG	367..518	CDD:238058	49/151 (32%)
		EGF	549..576	CDD:394967	15/26 (58%)
		LamG	791..936	CDD:238058	55/145 (38%)
		EGF_CA	964..995	CDD:238011	15/30 (50%)
		Laminin_G_2	1045..1174	CDD:396680	32/134 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm48964
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060