Protein Alignment Nrx-IV and cntnap5

DIOPT Version :10

• Sequence 1: NP_524034.2
• Gene: Nrx-IV / 39387
• FlyBaseID: FBgn0013997
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_031749305.1
• Gene: cntnap5 / 101730316
• XenbaseID: XB-GENE-6031102
• Length: 1307
• Species: Xenopus tropicalis
• Alignment Length: 1274
• Identity: 415/1274 - (32%)
• Similarity: 644/1274 - (50%)
• Gaps: 101/1274 - (7%)

  Fly    43 SDYDCNQPLMERAVLTATSSLTE----RGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMV 100
            :.|:|:.||.......|..|.:|    ||  .|:||   |...|||:|:....:|.:|||:...:
 Frog    25 ASYNCDDPLASPLPAPAFDSSSELFGSRG--DAKLNSREGAGGWTPLESNTRQWLQIDLGERFDI 87

  Fly   101 RKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWV 165
            ..:||.||..:.::|..|.:.:||.|..||.| :..:....|.||::.:.:..:.|:..|.|:::
 Frog    88 TGVATQGRYGSSDWVMSYSLMFSDTGRNWRPY-HQDNNIWAFAGNTNADGVVQHKFQHSIKARFL 151

  Fly   166 RINPTRWH--DRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGV 228
            |..||.|:  .||.||||:|||.|.|:.:.|:|...::|...::.:|:.|:.|..:||:..::||
 Frog   152 RFVPTEWNLVGRIGMRVEVYGCPYKSDVVDFDGRSSLQYRFNQKQMTTFKDVISLKFKSMQSDGV 216

  Fly   229 MMYSRGTQGDYYALQLKDNKMVLNLDLGSRVM------TSLSVGSLLDDNVWHDVVISRNQRDII 287
            :.:..|.:|||..|:|:..|:.|.::||...:      |.:::||||||..||.|:|.|..:.:.
 Frog   217 LFHGEGQRGDYITLELQKGKLSLYINLGDTKLRFGNTHTVVTLGSLLDDQQWHSVLIDRFNKQVN 281

  Fly   288 FSVDRVIVRGRIQGEFTRLNLNRELYLGGVP-NVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDS 351
            |:||:.....|.:|:...|:::.|...||:| ..:.|..:::||.||:||:|:|..|.|    |.
 Frog   282 FTVDKHTQHFRTKGDSDNLDIDYEFSFGGIPVPGKPGTFLKRNFHGCIENLYYNGVNII----DL 342

  Fly   352 TELGEGYLFTRVNTIYACPSPPIYPVTFTTRS-SFVRLKGYENSQRLNVSFYFRTYEETGVMLHH 415
            .:..:..:|...|..::|..|.:.|||||..| |::.|.|.......:|||.|||:...|::|..
 Frog   343 AKRRKPQIFIVGNVTFSCSEPHVIPVTFTNSSTSYLLLPGTPQMDGFSVSFEFRTWNGNGLLLTT 407

  Fly   416 DFYSGGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNID---QR 477
            .| |||...:.|:....|:.|::::...|:..:.....|||.||:..|:..::||.|.:|   ..
 Frog   408 QF-SGGSGVLLLQLVSGKLLLEIQEGEHILTLSSGSGLNDGLWHAVTINARRHRLTLTLDNAGSS 471

  Fly   478 PMTTTKSMQVATGAQYYIAGGKDK----------NGFVGCMRLISVDGNYKLPQDWVKGEEVCCG 532
            |.....|..|.:|::||..|..|.          ..|.|||||:.:|..   |:|.:..:....|
 Frog   472 PDHLAVSAAVFSGSRYYFGGCPDHLTDSHCIHPVPSFQGCMRLLFIDNQ---PKDLISVQRGLIG 533

  Fly   533 D--DVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQH 595
            :  :|.:|.|.:.|||.||.|||.|.|.|:...|:||||.|||..|.||:|....||.||::...
 Frog   534 NYSEVQIDTCGIRDRCLPNYCQHGGECSQSWNAFYCDCGATGYGEATCHSSLYQDSCEALRHRGF 598

  Fly   596 VQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQ 660
            ...  ..::|.||||||.|..|.|....| ::.|.:.|:....|.|.|......:.....|::..
 Frog   599 ASD--YYHIDPDGSGPLGPLRVFCNITED-KIWTLVPHNNTELTPVHGNFGVRPYAMLFNYNSTM 660

  Fly   661 LQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCEC 725
            .|:||::||:..|.|.::|.|:.|||.|||:.|    ||:|||.|..:...||.|:|||.:||.|
 Frog   661 EQLEAMINRAEYCEQEVAYHCKHSRLLNSPNGA----PFTWWIGRGTERHTYWGGSLPGVQKCAC 721

  Fly   726 GILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEG 790
            |:...|.|...:||||::..||..|.|.:..|::|||..:...|......|...|  :|||||.|
 Frog   722 GLEESCIDMRHFCNCDADKHEWTNDTGFLNFKDHLPVSQIVITDANRTGSEAAWR--IGPLRCYG 784

  Fly   791 DDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQF 855
            |..|.|.|:|..|.:.:..|.|....|.|:...|:||..:.|.....|..|::::.|....::.|
 Frog   785 DRSFWNAVSFNTASSFLPFPIFHPEFSADVSFFFKTTSASGVFLENLGVKDFMRIELISPYQVIF 849

  Fly   856 QYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREP-PGPVRALHLTSDL 919
            .:.|||||..|.:.:...|||..||.|..|||.|||.|:||...|...||. .|.:| |.|:|.|
 Frog   850 SFDAGSGPTEVLLHSVSALNDGQWHYVKAERNMKEATLIVDNQPKRLAREALDGRIR-LPLSSQL 913

  Fly   920 VIGATTEYRD-GYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCES--NPCLNNGTCIERY 981
            .:|.|...|. |:|||||:|..||:|:||||.: |....|..||.|.|.:  :.|.|||.|:|:.
 Frog   914 YVGGTLSNRQRGFVGCIRSLQFNGQMIDLKERA-RLTPDIRPGCPGHCGTYGHLCRNNGKCVEKR 977

  Fly   982 DGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFE---------GSFRST--------IAENIR 1029
            :||.|||..||::||.|..|:.....:.:.:.|.|:         .:|.|:        ..|||.
 Frog   978 NGYFCDCTNSAYEGPSCVKEVSAMFEAGTSVTYIFQEPYPVSKNASNFPSSPIYADTVISKENIS 1042

  Fly  1030 VGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFM 1094
            ..|.|......||..:| ...:||.:.:..:|.|:..:....|..: :|..:...|......|..
 Frog  1043 FSFVTGQAPSLLLHINS-FYHDYLAVLLIKNGSLQVRYKVSKEGTQ-VFTLESERLDNRRPHHVR 1105

  Fly  1095 RKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGK-----------NESMTDGFVGCV 1148
            ....|..:::::|......:||    |:|..|..|:.:.:||           .::.|.|||||:
 Frog  1106 ISREGRELIIQIDKMIKQRHNF----SSDIYFKAIKSLTLGKVVDNPGLDSEVAKANTFGFVGCL 1166

  Fly  1149 SRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIET----RPPPLVDEEKLR 1209
            |.||::.:.|||...:......|...|| |:|..||  .||...:...|    ...|...::...
 Frog  1167 SSVQYNHVAPLKAALRHPSIAPVTVTGT-LSECSCG--SVTESDLSTVTTTYSSSGPFGKDDDRE 1228

  Fly  1210 KAYNEV--DSVLLACLLVILFLLLILMFFLIGRYLHRHK 1246
            ...|.|  ||.::..::.:...::..:..::.:.|::||
 Frog  1229 PITNAVRSDSAVIGGVIAVTVFIIFCIVAIMTKILYQHK 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	57..184	CDD:238014	45/135 (33%)
		LamG	192..340	CDD:238058	50/154 (32%)
		LamG	376..514	CDD:238058	49/151 (32%)
		EGF	546..575	CDD:394967	17/28 (61%)
		LamG	819..943	CDD:214598	50/125 (40%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:460494	32/134 (24%)
		4.1m	1239..1255	CDD:128590	3/8 (38%)
cntnap5	XP_031749305.1	FA58C	44..172	CDD:238014	44/130 (34%)
		Laminin_G_2	208..337	CDD:460494	45/128 (35%)
		LamG	367..518	CDD:238058	49/151 (32%)
		EGF	549..576	CDD:394967	15/26 (58%)
		GGGWT_bact	<599..631	CDD:468872	12/34 (35%)
		Laminin_G_2	818..938	CDD:460494	49/120 (41%)
		EGF_CA	964..995	CDD:238011	15/30 (50%)
		Laminin_G_2	1045..1174	CDD:460494	32/134 (24%)