DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrx-IV and cntnap4

DIOPT Version :10

Sequence 1:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster
Sequence 2:XP_031746836.1 Gene:cntnap4 / 100498435 XenbaseID:XB-GENE-6052455 Length:1313 Species:Xenopus tropicalis


Alignment Length:1331 Identity:423/1331 - (31%)
Similarity:666/1331 - (50%) Gaps:135/1331 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 GLLCLLLLV--NNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLTERGPDK----ARLN-- 74
            |.||.||:|  .|.:.:.:|:      |.|||:..|......:..||.:|.....    ||||  
 Frog    10 GTLCQLLIVFLCNILATAKAE------SKYDCDGQLTSSLPQSHFSSSSELSSSHSAGFARLNRR 68

  Fly    75 -GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSE 138
             |...|:|:.:....:|.:|||:...:..|||.|:..:.::||.|::.:||.|..|:.|....|.
 Frog    69 DGAGGWSPLSSNKYQWLQIDLGERSEITGIATQGKYGSSDWVTSYVLMFSDTGRNWKQYHQEESI 133

  Fly   139 PQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRW--HDRISMRVELYGCDYISENLYFNGTGLVR 201
            .: |.||::.:|:.::..:..|||:::||.|..|  :.||.||||:|||.|.|:.:|.:|...:.
 Frog   134 SE-FIGNTNADSVVHHKLQNHIIARFLRIAPVNWNSYGRIGMRVEMYGCAYRSDMVYLDGKSSIL 197

  Fly   202 YDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLG------SRVM 260
            |..:::.:::.|:.|..:|||..::||:::..|..||:..|||...::.|.::||      |...
 Frog   198 YRFQQKLMSTVKDVISLKFKTMQSDGVLLHGDGQNGDHITLQLIKGQLSLIINLGNAQFHPSTPH 262

  Fly   261 TSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGL- 324
            .::|:||||||..||.|:|.|..|.:.|||||.::...::|:...|:::.||..||:|...:.: 
 Frog   263 VNVSLGSLLDDQQWHSVIIERFSRQVNFSVDRHVLHFFMKGDTYHLDIDYELSFGGIPLKGKSVS 327

  Fly   325 IVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGY---LFTRVNTIYACPSPPIYPVTFTTRSSFV 386
            ::|:||.||.||:|:|..|.|       :|.:.|   ::...|..|:|..|...||||...:||:
 Frog   328 LLQKNFHGCFENLYYNGVNII-------DLAKRYKPQIYIVGNISYSCVEPETVPVTFLNSNSFL 385

  Fly   387 RLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGGY-LKVFLEFGKVKIDLKVKDKARI-ILDNY 449
            .|:|.: ...|.|.|.|||:.:.|.:..:....... |.:::..||.|:.|....:::. ....:
 Frog   386 ALRGLQ-QDGLAVHFQFRTWNKDGTLFSYKLGPESLDLVLYMTDGKFKMSLFKHGRSQSNTATGF 449

  Fly   450 DDQFNDGKWHSFVISIEKNRLILNIDQR---PMTTTKSMQVATGAQYYIAGGKDKN--------- 502
            |  .|:|.|||.....::||||:.||.:   .:.|...:|:.:|..||..|..|.|         
 Frog   450 D--LNNGHWHSLSFVGKRNRLIVTIDNQETLSLQTALPIQLGSGHYYYFGGCPDNNTDHGCFSPV 512

  Fly   503 -GFVGCMRLISVDGNYKLPQDWVKGEEVCCGD--DVVVDACQMIDRCNPNPCQHKGLCHQNSREF 564
             .|:||::|||:..|.   .|.:..::...|:  |:..|.|.:||||.||.|:|:|.|.|...:|
 Frog   513 KSFLGCVKLISIGSNL---IDIISIQQGKFGNFTDLQFDICGIIDRCLPNYCEHRGQCSQTWNDF 574

  Fly   565 FCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLN----LDVDGSGPLEPFPVTCEFYSDG 625
            :|:|..|||.||.||.|....||.|.|:      :.|.:    :|.|||||||||.|.|....  
 Frog   575 YCNCSETGYTGATCHYSIYEKSCEAYKH------KGNTSGFFLIDPDGSGPLEPFAVYCNMLD-- 631

  Fly   626 RVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSP 690
            ..:|.:||:......|....:......:..|.|:..|::|..:.:..|.|.|:|.|:.||:.:..
 Frog   632 TAVTVISHNNTDMNKVKNSNKENPHVMNFKYFADLAQLQATTDNAEHCKQELAYHCKKSRILHKQ 696

  Fly   691 SEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIR 755
            |..    |:|||:.|.|:...||:|:.|...||.|||...|.|...:||||::..||..|.|.:.
 Frog   697 SHI----PYSWWVGRTNETQTYWSGSSPDVSKCTCGIEENCIDSQLYCNCDADKSEWSNDTGFLS 757

  Fly   756 EKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDI 820
            .|::|||..:...||..|..|  ..|.||||.|.||..|.|..:|....:.::.|......|.|:
 Frog   758 YKDHLPVTKIVITDTDRPQSE--AAYKLGPLLCWGDRSFWNSASFNTVSSYLHFPTLHGEISADV 820

  Fly   821 YLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVE 885
            ...|:|:..:.:.....|..|:|::.|....::.|.:..|:||.||.|.:..:||||.||.:..|
 Frog   821 SFFFKTSSPSGLFLENLGIKDFIRIELQSPTEVVFSFDVGNGPFGVTVQSPSNLNDNQWHFIKAE 885

  Fly   886 RNRKEARLVVDGSIKAEVREP-PGPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKE 949
            ||.|||.|.||...:..:..| .|.:| |.|.|.|.||.|...:.|::||||.|.|||..:||:|
 Frog   886 RNIKEASLQVDQLPQKTIITPSDGHIR-LQLNSQLYIGGTASRQKGFLGCIRYLTLNGIALDLEE 949

  Fly   950 YSKRGLYGISTGCVGRCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSII 1012
            .:| ...||..||.|.|.|  |.|.|.|.|.|:::|:.|||..||:.||.|..||.......|..
 Frog   950 RAK-VTPGIKPGCPGHCSSYGNLCHNGGKCEEKHNGFLCDCNSSAYGGPFCKKEISAYFGGGSSA 1013

  Fly  1013 RYEFEGSFRSTIA-----------------ENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNS 1060
            ...|..::  ||:                 |||...|.||.....|| |.|:...:|::|.|:.:
 Frog  1014 TLTFPENY--TISRNASWYSSAQHPDTNSRENIAFSFRTTQSPSLLL-FVSSFNKQYISIIIAKN 1075

  Fly  1061 GHLRCVFDFGFERQEIIF--PKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASAD 1123
            |.|:..:.........:|  ..|:...|....:..:||  |.|:.::|:.|..|:::.    ::.
 Frog  1076 GSLQIRYKLEHHLDPDVFNINTKNLVDGHLQKVRILRK--GETLFIEVNQYTAVKFSL----TSV 1134

  Fly  1124 AQFNNIQYMYIGK----NESM--------TDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGT 1176
            .:|..:|::.:||    |:.:        .:||:||:|.:.|:.|:|||.:........|.:.| 
 Frog  1135 TEFKAVQFLILGKILAENDELDLETMKANANGFIGCLSSMHFNHIFPLKTVLYHEKSPQVITTG- 1198

  Fly  1177 QLTEDFCG-VEPV-------THPPIEIETRPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLIL 1233
            .:||..|| |..:       ||...: .:||..  :.|.:..|.....:|:...:.|:.|:||.:
 Frog  1199 HITESSCGSVNGIDSASSESTHTFAD-HSRPKD--EREPIANAIRSDSAVIGGVISVVTFILLCI 1260

  Fly  1234 MFFLIGRYLHRHKGDYLTHEDQGADGADDPD 1264
            ....|..||  .|..|..:|.:.::..|:.|
 Frog  1261 TAIAIRIYL--QKNTYKKNEAKASENEDNTD 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nrx-IVNP_524034.2 FA58C 57..184 CDD:238014 44/135 (33%)
LamG 192..340 CDD:238058 53/154 (34%)
LamG 376..514 CDD:238058 46/152 (30%)
EGF 546..575 CDD:394967 14/28 (50%)
LamG 819..943 CDD:214598 47/124 (38%)
EGF_CA 966..998 CDD:238011 16/33 (48%)
Laminin_G_2 1032..1156 CDD:460494 33/137 (24%)
4.1m 1239..1255 CDD:128590 5/15 (33%)
cntnap4XP_031746836.1 FA58C 36..180 CDD:238014 45/144 (31%)
Laminin_G_2 216..345 CDD:460494 49/128 (38%)
Laminin_G_2 401..527 CDD:460494 35/127 (28%)
EGF_CA 553..588 CDD:238011 19/34 (56%)
GGGWT_bact 596..>629 CDD:468872 17/38 (45%)
COLFI 607..>690 CDD:470578 25/84 (30%)
Laminin_G_2 824..943 CDD:460494 46/119 (39%)
EGF_CA 965..1000 CDD:238011 16/34 (47%)
Laminin_G_2 1048..1179 CDD:460494 33/137 (24%)

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