DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrx-IV and cntnap4

DIOPT Version :9

Sequence 1:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_031746836.1	Gene:	cntnap4 / 100498435	XenbaseID:	XB-GENE-6052455	Length:	1313	Species:	Xenopus tropicalis

Alignment Length:	1331	Identity:	423/1331 - (31%)
Similarity:	666/1331 - (50%)	Gaps:	135/1331 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GLLCLLLLV--NNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLTERGPDK----ARLN-- 74
            |.||.||:|  .|.:.:.:|:      |.|||:..|......:..||.:|.....    ||||
Frog    10 GTLCQLLIVFLCNILATAKAE------SKYDCDGQLTSSLPQSHFSSSSELSSSHSAGFARLNRR 68

  Fly    75 -GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSE 138
             |...|:|:.:....:|.:|||:...:..|||.|:..:.::||.|::.:||.|..|:.|....|.
Frog    69 DGAGGWSPLSSNKYQWLQIDLGERSEITGIATQGKYGSSDWVTSYVLMFSDTGRNWKQYHQEESI 133

  Fly   139 PQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRW--HDRISMRVELYGCDYISENLYFNGTGLVR 201
            .: |.||::.:|:.::..:..|||:::||.|..|  :.||.||||:|||.|.|:.:|.:|...:.
Frog   134 SE-FIGNTNADSVVHHKLQNHIIARFLRIAPVNWNSYGRIGMRVEMYGCAYRSDMVYLDGKSSIL 197

  Fly   202 YDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLG------SRVM 260
            |..:::.:::.|:.|..:|||..::||:::..|..||:..|||...::.|.::||      |...
Frog   198 YRFQQKLMSTVKDVISLKFKTMQSDGVLLHGDGQNGDHITLQLIKGQLSLIINLGNAQFHPSTPH 262

  Fly   261 TSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGL- 324
            .::|:||||||..||.|:|.|..|.:.|||||.::...::|:...|:::.||..||:|...:.:
Frog   263 VNVSLGSLLDDQQWHSVIIERFSRQVNFSVDRHVLHFFMKGDTYHLDIDYELSFGGIPLKGKSVS 327

  Fly   325 IVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGY---LFTRVNTIYACPSPPIYPVTFTTRSSFV 386
            ::|:||.||.||:|:|..|.|       :|.:.|   ::...|..|:|..|...||||...:||:
Frog   328 LLQKNFHGCFENLYYNGVNII-------DLAKRYKPQIYIVGNISYSCVEPETVPVTFLNSNSFL 385

  Fly   387 RLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGGY-LKVFLEFGKVKIDLKVKDKARI-ILDNY 449
            .|:|.: ...|.|.|.|||:.:.|.:..:....... |.:::..||.|:.|....:::. ....:
Frog   386 ALRGLQ-QDGLAVHFQFRTWNKDGTLFSYKLGPESLDLVLYMTDGKFKMSLFKHGRSQSNTATGF 449

  Fly   450 DDQFNDGKWHSFVISIEKNRLILNIDQR---PMTTTKSMQVATGAQYYIAGGKDKN--------- 502
            |  .|:|.|||.....::||||:.||.:   .:.|...:|:.:|..||..|..|.|
Frog   450 D--LNNGHWHSLSFVGKRNRLIVTIDNQETLSLQTALPIQLGSGHYYYFGGCPDNNTDHGCFSPV 512

  Fly   503 -GFVGCMRLISVDGNYKLPQDWVKGEEVCCGD--DVVVDACQMIDRCNPNPCQHKGLCHQNSREF 564
             .|:||::|||:..|.   .|.:..::...|:  |:..|.|.:||||.||.|:|:|.|.|...:|
Frog   513 KSFLGCVKLISIGSNL---IDIISIQQGKFGNFTDLQFDICGIIDRCLPNYCEHRGQCSQTWNDF 574

  Fly   565 FCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLN----LDVDGSGPLEPFPVTCEFYSDG 625
            :|:|..|||.||.||.|....||.|.|:      :.|.:    :|.|||||||||.|.|....
Frog   575 YCNCSETGYTGATCHYSIYEKSCEAYKH------KGNTSGFFLIDPDGSGPLEPFAVYCNMLD-- 631

  Fly   626 RVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSP 690
            ..:|.:||:......|....:......:..|.|:..|::|..:.:..|.|.|:|.|:.||:.:..
Frog   632 TAVTVISHNNTDMNKVKNSNKENPHVMNFKYFADLAQLQATTDNAEHCKQELAYHCKKSRILHKQ 696

  Fly   691 SEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIR 755
            |..    |:|||:.|.|:...||:|:.|...||.|||...|.|...:||||::..||..|.|.:.
Frog   697 SHI----PYSWWVGRTNETQTYWSGSSPDVSKCTCGIEENCIDSQLYCNCDADKSEWSNDTGFLS 757

  Fly   756 EKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDI 820
            .|::|||..:...||..|..|  ..|.||||.|.||..|.|..:|....:.::.|......|.|:
Frog   758 YKDHLPVTKIVITDTDRPQSE--AAYKLGPLLCWGDRSFWNSASFNTVSSYLHFPTLHGEISADV 820

  Fly   821 YLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVE 885
            ...|:|:..:.:.....|..|:|::.|....::.|.:..|:||.||.|.:..:||||.||.:..|
Frog   821 SFFFKTSSPSGLFLENLGIKDFIRIELQSPTEVVFSFDVGNGPFGVTVQSPSNLNDNQWHFIKAE 885

  Fly   886 RNRKEARLVVDGSIKAEVREP-PGPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKE 949
            ||.|||.|.||...:..:..| .|.:| |.|.|.|.||.|...:.|::||||.|.|||..:||:|
Frog   886 RNIKEASLQVDQLPQKTIITPSDGHIR-LQLNSQLYIGGTASRQKGFLGCIRYLTLNGIALDLEE 949

  Fly   950 YSKRGLYGISTGCVGRCES--NPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSII 1012
            .:| ...||..||.|.|.|  |.|.|.|.|.|:::|:.|||..||:.||.|..||.......|..
Frog   950 RAK-VTPGIKPGCPGHCSSYGNLCHNGGKCEEKHNGFLCDCNSSAYGGPFCKKEISAYFGGGSSA 1013

  Fly  1013 RYEFEGSFRSTIA-----------------ENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNS 1060
            ...|..::  ||:                 |||...|.||.....|| |.|:...:|::|.|:.:
Frog  1014 TLTFPENY--TISRNASWYSSAQHPDTNSRENIAFSFRTTQSPSLLL-FVSSFNKQYISIIIAKN 1075

  Fly  1061 GHLRCVFDFGFERQEIIF--PKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASAD 1123
            |.|:..:.........:|  ..|:...|....:..:||  |.|:.::|:.|..|:::.    ::.
Frog  1076 GSLQIRYKLEHHLDPDVFNINTKNLVDGHLQKVRILRK--GETLFIEVNQYTAVKFSL----TSV 1134

  Fly  1124 AQFNNIQYMYIGK----NESM--------TDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGT 1176
            .:|..:|::.:||    |:.:        .:||:||:|.:.|:.|:|||.:........|.:.|
Frog  1135 TEFKAVQFLILGKILAENDELDLETMKANANGFIGCLSSMHFNHIFPLKTVLYHEKSPQVITTG- 1198

  Fly  1177 QLTEDFCG-VEPV-------THPPIEIETRPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLIL 1233
            .:||..|| |..:       ||...: .:||..  :.|.:..|.....:|:...:.|:.|:||.:
Frog  1199 HITESSCGSVNGIDSASSESTHTFAD-HSRPKD--EREPIANAIRSDSAVIGGVISVVTFILLCI 1260

  Fly  1234 MFFLIGRYLHRHKGDYLTHEDQGADGADDPD 1264
            ....|..||  .|..|..:|.:.::..|:.|
Frog  1261 TAIAIRIYL--QKNTYKKNEAKASENEDNTD 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	48/147 (33%)
		FA58C	57..184	CDD:238014	44/135 (33%)
		LamG	192..340	CDD:238058	53/154 (34%)
		LamG	376..514	CDD:238058	46/152 (30%)
		EGF	546..575	CDD:278437	14/28 (50%)
		Laminin_G_2	824..943	CDD:280389	46/119 (39%)
		EGF_CA	966..998	CDD:238011	16/33 (48%)
		Laminin_G_2	1032..1156	CDD:280389	33/137 (24%)
		4.1m	1239..1255	CDD:128590	5/15 (33%)
cntnap4	XP_031746836.1	FA58C	36..180	CDD:238014	45/144 (31%)
		Laminin_G_2	216..345	CDD:396680	49/128 (38%)
		Laminin_G_2	401..527	CDD:396680	35/127 (28%)
		EGF_CA	553..588	CDD:238011	19/34 (56%)
		COLFI	607..>690	CDD:413320	25/84 (30%)
		Laminin_G_2	824..943	CDD:396680	46/119 (39%)
		EGF_CA	965..1000	CDD:238011	16/34 (47%)
		Laminin_G_2	1048..1179	CDD:396680	33/137 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I769
OMA	1	1.010	-	-		QHG48725
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	1	1.000	-	-		FOG0000323
OrthoInspector	1	1.000	-	-		otm48964
Panther	1	1.100	-	-	LDO	PTHR15036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080