Protein Alignment eIF3l and EIF3L

DIOPT Version :9

• Sequence 1: NP_648553.1
• Gene: eIF3l / 39386
• FlyBaseID: FBgn0036258
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_006724323.1
• Gene: EIF3L / 51386
• HGNCID: 18138
• Length: 580
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 276/533 - (51%)
• Similarity: 368/533 - (69%)
• Gaps: 44/533 - (8%)

  Fly     2 YGGDEYATNSDYYDDYA-------HTGDPQLDMEYERNY----YAARMPDNVKYFLINFCQAIK- 54
            |..|:|.:.: .||.||       |||||:.|:.|||.|    |.. :|:.:|.|:..|.:.:.
Human    46 YPADDYESEA-AYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQV-IPEVIKNFIQYFHKTVSD 108

  Fly    55 -------------------EGNLYDIQNMYENTFPQISDHHFDKTAWPEEQEVAAIVDNDKVFLI 100
                               :..:|:||::|||::.::::..|..|.|||.:.:|..|.||.||||
Human   109 LIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLI 173

  Fly   101 LYKELYYRHIHARIPGGPKLEQRINSFFNYCDFFNLIISAQNPVMLELPDIWLWELVDEFVYQFQ 165
            ||||||||||:|::.|||.||||..|::|||:.||.|::|..|..||||:.|||:::|||:||||
Human   174 LYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQ 238

  Fly   166 NFAQYRARLTEKSQDEIQQLCVNHSNE--WSILCILNVLHSLVDISNIKKQLEAISQGVDPQTVA 228
            :|:|||.:..:||::||..|   .||.  |::..:|||||||||.|||.:|||..:.|.||::||
Human   239 SFSQYRCKTAKKSEEEIDFL---RSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVA 300

  Fly   229 GDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFA 293
            |::|:.|.||||||||||||||:|||||||||||||||.||::|||.||.:|.||::|.||||||
Human   301 GEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFA 365

  Fly   294 YMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQ 358
            |:|||||.||||.|::|||||||||.::...:|:.:.||||.|||:.||||.|.::|..|||||.
Human   366 YLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIH 430

  Fly   359 QVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAVDAPMDDYVKDPMEHQLQVFMDEV 423
            ..|||| |.|.|.:||.||.:|::..|.::||:|:||..|..|....:|.|:|...||:||.|||
Human   431 LQLREK-YGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEV 494

  Fly   424 RQQKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEG 488
            :||..|.|.||:||||||:|:.|||.|:|....|     ..|:||.|||||:||||:.|.|.|:|
Human   495 QQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQE-----FRIQLLVFKHKMKNLVWTSGISALDG 554

  Fly   489 TFKSGSELDFYID 501
            .|:|.||:|||||
Human   555 EFQSASEVDFYID 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3l	NP_648553.1	Paf67	122..527	CDD:287257	219/382 (57%)
EIF3L	XP_006724323.1	Paf67	195..568	CDD:287257	219/382 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149990
Domainoid	1	1.000	483	1.000	Domainoid score	I409
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9380
Inparanoid	1	1.050	590	1.000	Inparanoid score	I991
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53715
OrthoDB	1	1.010	-	-		D393910at2759
OrthoFinder	1	1.000	-	-		FOG0006510
OrthoInspector	1	1.000	-	-		oto88492
orthoMCL	1	0.900	-	-		OOG6_102359
Panther	1	1.100	-	-	LDO	PTHR13242
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2511
SonicParanoid	1	1.000	-	-		X4745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940