DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3l and Eif3l

DIOPT Version :9

Sequence 1:	NP_648553.1	Gene:	eIF3l / 39386	FlyBaseID:	FBgn0036258	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001029306.1	Gene:	Eif3l / 300069	RGDID:	1308230	Length:	382	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	226/394 - (57%)
Similarity:	288/394 - (73%)	Gaps:	18/394 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LELPDIWLWELVDEFVYQFQNFAQYRARLTEKSQDEIQQLCVNHSNE--WSILCILNVLHSLVDI 208
            :.||..:|       :.|||:|:|||.:..:||::||..|   .||.  |::..:|||||||||.
  Rat     1 MPLPHCFL-------LQQFQSFSQYRCKTAKKSEEEIDFL---RSNPKIWNVHSVLNVLHSLVDK 55

  Fly   209 SNIKKQLEAISQGVDPQTVAGDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKK 273
            |||.:|||..:.|.||::|||::|:.|.||||||||||||||:|||||||||||||||.||::||
  Rat    56 SNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKK 120

  Fly   274 SAYSHIPACQISTSYYVGFAYMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQM 338
            |.||.:|.||::|.|||||||:|||||.||||.|::|||||||||.::...:|:.:.||||.|||
  Rat   121 SMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQM 185

  Fly   339 YHLLAICLVLHPQCIDESIQQVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAVDAP 403
            :.||||.|.::|..|||||...|||| |.|.|.:||.||.:|::..|.:|||:|:||..|..|..
  Rat   186 HALLAIALTMYPMRIDESIHLQLREK-YGDKMLRMQKGDPQVYEELFSYACPKFLSPVVPNYDNV 249

  Fly   404 MDDYVKDPMEHQLQVFMDEVRQQKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLL 468
            ..:|.|:|...||:||.|||:||..|.|.||:||||||:|:.|||.|:|....|     ..|:||
  Rat   250 HPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQE-----FRIQLL 309

  Fly   469 CFKHKMRNLVWSKGPSGLEGTFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKILKFNDLNRK 533
            .|||||:||||:.|.|.|:|.|:|.||:|||||.||||||||||:.||||||:|:|.||.:|||.
  Rat   310 VFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRT 374

  Fly   534 LKNI 537
            ||.:
  Rat   375 LKKM 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3l	NP_648553.1	Paf67	122..527	CDD:287257	219/382 (57%)
Eif3l	NP_001029306.1	Paf67	11..368	CDD:287257	216/365 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343902
Domainoid	1	1.000	428	1.000	Domainoid score	I580
eggNOG	1	0.900	-	-		E1_KOG3677
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1625
OMA	1	1.010	-	-		QHG53715
OrthoDB	1	1.010	-	-		D393910at2759
OrthoFinder	1	1.000	-	-		FOG0006510
OrthoInspector	1	1.000	-	-		oto95631
orthoMCL	1	0.900	-	-		OOG6_102359
Panther	1	1.100	-	-	LDO	PTHR13242
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4745
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770