DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3l and Eif3l

DIOPT Version :9

Sequence 1:	NP_648553.1	Gene:	eIF3l / 39386	FlyBaseID:	FBgn0036258	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_660121.2	Gene:	Eif3l / 223691	MGIID:	2386251	Length:	564	Species:	Mus musculus

Alignment Length:	567	Identity:	300/567 - (52%)
Similarity:	396/567 - (69%)	Gaps:	40/567 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YGGDEYATNSDYYDDYA-------HTGDPQLDMEYERNY----YAARMPDNVKYFLINFCQAIK- 54
            |..|:|.:.: .||.||       |||||:.|:.|||.|    |.. :|:.:|.|:..|.:.:.
Mouse     3 YPADDYESEA-AYDPYAYPGDYDMHTGDPKQDLAYERQYEQQTYQV-IPEVIKNFIQYFHKTVSD 65

  Fly    55 -------------------EGNLYDIQNMYENTFPQISDHHFDKTAWPEEQEVAAIVDNDKVFLI 100
                               :..:|:||::|||::.::::..|..|.|||.:.:|..|.||.||||
Mouse    66 LIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLI 130

  Fly   101 LYKELYYRHIHARIPGGPKLEQRINSFFNYCDFFNLIISAQNPVMLELPDIWLWELVDEFVYQFQ 165
            ||||||||||:|::.|||.||||..|::|||:.||.|::|..|..||||:.|||:::|||:||||
Mouse   131 LYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQ 195

  Fly   166 NFAQYRARLTEKSQDEIQQLCVNHSNEWSILCILNVLHSLVDISNIKKQLEAISQGVDPQTVAGD 230
            :|:|||.:..:||:.|:..|..| ...|::..:|||||||||.|||.:|||..:.|.||::|||:
Mouse   196 SFSQYRCKTAKKSEGEMDFLRSN-PKVWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGE 259

  Fly   231 FGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFAYM 295
            :|:.|.||||||||||||||:|||||||||||||||.||::|||.||.:|.||::|.|||||||:
Mouse   260 YGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYL 324

  Fly   296 MMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQQV 360
            |||||.||||.|::|||||||||.::...:|:.:.||||.|||:.||||.|.::|..|||||...
Mouse   325 MMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQ 389

  Fly   361 LREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAVDAPMDDYVKDPMEHQLQVFMDEVRQ 425
            |||| |.|.|.:||.||.:|::..|.:|||:|:||..|..|....:|.|:|...||:||.|||:|
Mouse   390 LREK-YGDKMLRMQKGDPQVYEELFSYACPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQ 453

  Fly   426 QKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEGTF 490
            |..|.|.||:||||||:|:.|||.|:|....|     ..|:||.|||||:||||:.|.|.|:|.|
Mouse   454 QAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQE-----FRIQLLVFKHKMKNLVWTSGISALDGEF 513

  Fly   491 KSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKILKFNDLNRKLKNI 537
            :|.||:|||||.||||||||||:.||||||:|:|.||.:|||.||.:
Mouse   514 QSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKM 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3l	NP_648553.1	Paf67	122..527	CDD:287257	236/404 (58%)
Eif3l	NP_660121.2	Paf67	152..550	CDD:287257	236/404 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840043
Domainoid	1	1.000	483	1.000	Domainoid score	I405
eggNOG	1	0.900	-	-		E1_KOG3677
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9380
Inparanoid	1	1.050	590	1.000	Inparanoid score	I988
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53715
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006510
OrthoInspector	1	1.000	-	-		oto92062
orthoMCL	1	0.900	-	-		OOG6_102359
Panther	1	1.100	-	-	LDO	PTHR13242
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2511
SonicParanoid	1	1.000	-	-		X4745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790