DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP68F and ARHGAP44

DIOPT Version :10

Sequence 1:NP_001401037.1 Gene:RhoGAP68F / 39385 FlyBaseID:FBgn0036257 Length:485 Species:Drosophila melanogaster
Sequence 2:NP_055674.4 Gene:ARHGAP44 / 9912 HGNCID:29096 Length:818 Species:Homo sapiens


Alignment Length:530 Identity:124/530 - (23%)
Similarity:204/530 - (38%) Gaps:166/530 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 QLYRNRPAINPIVDNSDEPQPSLSDLHDFEPKLEF-------------------------DDTEL 56
            |..|.|...|..|..:::.:....||...|.:||.                         ..::.
Human     4 QFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKK 68

  Fly    57 LAPSPLEKDVMVGDFVLAEDPELEPEEDVNPLEDDFEDQLREQSENF--QTPRNKCD--FL---- 113
            |..:.|.:.:|.|..:|.:|..|   ..:..|..:.||:|.::..:|  |..|:..:  ||    
Human    69 LPLTTLAQCLMEGSAILGDDTLL---GKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEV 130

  Fly   114 ---GTDKQGRHIFGIY------ASRFPEKSQLEGF-------------VREIIKEIEPFVE--ND 154
               ...||.:|:..:.      .:|:.:.|:..|.             :||.::|....||  .|
Human   131 EIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRD 195

  Fly   155 YILVYFHQGLKEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFI---SDK 216
            .:              ||.......||:|          |.           |:|...|   ::.
Human   196 QL--------------SADMYSFVAKEID----------YA-----------NYFQTLIEVQAEY 225

  Fly   217 FRKKLVYISSLDELRQALGLNKLKLPDNICDLDDKLNPSRKPSTPPPSSNINASRQQQHKMATTH 281
            .||.|..:.::             ||.                          .:.||.......
Human   226 HRKSLTLLQAV-------------LPQ--------------------------IKAQQEAWVEKP 251

  Fly   282 QFGVPLKFIVMNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERVN-RGEDV 345
            .||.||:..:..|....:.|  :..||..|...| :..||:||.:.:.|::..||..:: ...||
Human   252 SFGKPLEEHLTISGREIAFP--IEACVTMLLECG-MQEEGLFRVAPSASKLKKLKAALDCCVVDV 313

  Fly   346 DLKSVNVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPK----EERSRNVTQLIR--EKLPE 404
            ...|.:.|.|||.|||:||:|.|||:|||||:      :|.:    :|:.:.:..|..  ||||:
Human   314 QEYSADPHAIAGALKSYLRELPEPLMTFELYD------EWIQASNVQEQDKKLQALWNACEKLPK 372

  Fly   405 ENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGPNFLWSRS--------TSTSLEEIAPINAF 461
            .|:...:|:::||.::.:.:|:||||.||:|||.|||.||.::        |:.||:.:..|...
Human   373 ANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPI 437

  Fly   462 VDFVLQNHKD 471
            :     .|.|
Human   438 I-----QHAD 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP68FNP_001401037.1 CRAL_TRIO_2 119..242 CDD:463965 22/146 (15%)
RhoGAP-p50rhoGAP 278..473 CDD:239869 70/209 (33%)
ARHGAP44NP_055674.4 BAR_Rich2 13..260 CDD:153303 55/323 (17%)
RhoGAP 249..449 CDD:470621 70/208 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..493
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..772
PTZ00449 <558..>674 CDD:185628
Interaction with BST2. /evidence=ECO:0000269|PubMed:19273615 731..818
PDZ-binding 764..767
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 789..818
PDZ-binding. /evidence=ECO:0000305 815..818
Blue background indicates that the domain is not in the aligned region.

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