DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP68F and ARHGAP12

DIOPT Version :10

Sequence 1:NP_001401037.1 Gene:RhoGAP68F / 39385 FlyBaseID:FBgn0036257 Length:485 Species:Drosophila melanogaster
Sequence 2:NP_060757.4 Gene:ARHGAP12 / 94134 HGNCID:16348 Length:846 Species:Homo sapiens


Alignment Length:491 Identity:122/491 - (24%)
Similarity:194/491 - (39%) Gaps:117/491 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 IVDNSDEPQPSLSDLHDFEPKLEFDDTELLAPSPLEKDVMVGDFVLAEDPELEPEEDVNPLEDDF 92
            ::|.:|:..|:.|       |..|.:.|....||..:|.       |..|  :.:|....|    
Human   426 VLDTNDKESPTAS-------KPCFPENESSPSSPKHQDT-------ASSP--KDQEKYGLL---- 470

  Fly    93 EDQLREQSENFQTPRNK----------CDFLGTDKQGRHI--FGIYASRFPEKS-QLEGFVREII 144
              .:.:.:||.:..|..          ...|.|..||...  ||...|: ||.: .|:|...|:.
Human   471 --NVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSK-PEFTVDLKGATIEMA 532

  Fly   145 KEIEPFVENDYILVYFHQG----LKEDN--------KPSAQFLWNSYKELDRNFRKNLKTLYVVH 197
            .:.:...:|.:.| ...||    ::.||        |..:..:.|...|.|....:.:..     
Human   533 SKDKSSKKNVFEL-KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPD----- 591

  Fly   198 PTWFIRVIWNFFSPFIS--DKFR-----KKL--VYISSLDELRQALGLNKLKLPDNICDLDDKLN 253
                        ||.|.  ||.:     |||  ..:||:|...|.      |...|:     |..
Human   592 ------------SPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQK------KTKKNL-----KKF 633

  Fly   254 PSRKPSTPPPSSNINASRQQQHKMATTHQFGVPLKFIVMNSPCLN-------SIPPIVRKCVDSL 311
            .:|:|:       :.|.|::.:           :|..|..|...|       ::|..|:.|::.:
Human   634 LTRRPT-------LQAVREKGY-----------IKDQVFGSNLANLCQRENGTVPKFVKLCIEHV 680

  Fly   312 SITGVIDTEGIFRRSGNHSEIMALKERVNRGEDVDL---KSVNVHVIAGLLKSFLRDLAEPLLTF 373
            ...| :|.:||:|.|||.:.|..|:..||..|.:||   |..::|||.|.||.|.|:|.|||.||
Human   681 EEHG-LDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTF 744

  Fly   374 ELYEDVTGFLDWPKEERSRNVTQLIREKLPEENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVF 438
            ..:.|....:.....:|...|..|||: ||:.|.:..:.:...|.||::..:.|:||..::||||
Human   745 NHFNDFVNAIKQEPRQRVAAVKDLIRQ-LPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVF 808

  Fly   439 GPNFLW-SRSTSTSLEEIAPINAFVDFVLQNHKDIY 473
            ||..|. .:.|..........|..|:.:|.....|:
Human   809 GPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIF 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP68FNP_001401037.1 CRAL_TRIO_2 119..242 CDD:463965 32/146 (22%)
RhoGAP-p50rhoGAP 278..473 CDD:239869 63/205 (31%)
ARHGAP12NP_060757.4 SH3_ARHGAP12 15..74 CDD:213003
SH3-WW_linker 71..266 CDD:435468
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 152..241
PRP40 259..>412 CDD:227435
WW 268..298 CDD:238122
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..316
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..466 12/53 (23%)
PH_ARHGAP9-like 465..576 CDD:270053 24/118 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 580..629 15/71 (21%)
RhoGAP_ARHGAP27_15_12_9 654..839 CDD:239868 61/186 (33%)
Blue background indicates that the domain is not in the aligned region.

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