Protein Alignment RhoGAP68F and Ralbp1

DIOPT Version :10

• Sequence 1: NP_001401037.1
• Gene: RhoGAP68F / 39385
• FlyBaseID: FBgn0036257
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_114456.2
• Gene: Ralbp1 / 84014
• RGDID: 621134
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 425
• Identity: 104/425 - (24%)
• Similarity: 159/425 - (37%)
• Gaps: 118/425 - (27%)

  Fly    23 PAINPIVDNSDEPQPSLSDLHDFEPKLEFDDTELLAPSPLEKD--VMVGDFVLAEDPELEPEEDV 85
            |...|.:..:.||.|....||: .|.:..||         |||  ...|.|   :..|...|...
  Rat    35 PTKFPGLYRTGEPSPPHDILHE-PPDIVSDD---------EKDHGKKKGKF---KKKEKRTEGYA 86

  Fly    86 NPLEDDFEDQLREQSENFQTPRNKCDFLGTDKQGRHIFGIYASRFPEKSQLEGFVREIIKEIEPF 150
            ...||...|:....|   :..|:|         |.|:|  ....|.:|.:.:..::|..|| |..
  Rat    87 AFQEDSSGDEAESPS---KMKRSK---------GIHVF--KKPSFSKKKEKDFKIKEKPKE-EKH 136

  Fly   151 VENDYILVYFHQGLKEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISD 215
            .|..:         ||:          .:||
  Rat   137 KEEKH---------KEE----------KHKE---------------------------------- 148

  Fly   216 KFRKKLVYISSLDELRQALGLNKLKLPDNICDLDDKLNPSRKPSTPPPSSNINASRQQQHKMATT 280
               ||...:::.|.::|.....|.|.|....::.....||.:|.
  Rat   149 ---KKCKDLTAADVVKQWKEKKKKKKPTQEPEVPQTDAPSLRPI--------------------- 189

  Fly   281 HQFGVPLKFIVMNSPCLNSI--PPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERVNRGE 343
              ||.||...|..:...:.|  |.:.|:|||.:...| :..|||:|.||..|::..||...:|.|
  Rat   190 --FGAPLADAVERTMMYDGIRLPAVFRECVDYMEKHG-MKCEGIYRVSGIKSKVDELKAAYDREE 251

  Fly   344 DVDLKSVNVHVIAGLLKSFLRDLAEPLLTFEL---YEDVTGFLDWPKEERSRNVTQLIREKLPEE 405
            ..:|:....:.:|.|||.:||||.|.|||.||   :|:..|  ...:.|:.:...:|:|| |||.
  Rat   252 SPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACG--RTTEVEKVQEFQRLLRE-LPEY 313

  Fly   406 NYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGP 440
            |:.|..:::..:..|:..|...||...|::||..|
  Rat   314 NHLLLSWLIVHMDHVIAKELETKMNIQNISIVLSP 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001401037.1	CRAL_TRIO_2	119..242	CDD:463965	20/122 (16%)
		RhoGAP-p50rhoGAP	278..473	CDD:239869	57/168 (34%)
Ralbp1	NP_114456.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..151		38/199 (19%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9PT60	102..119		6/27 (22%)
		Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000250|UniProtKB:Q15311	154..219		18/87 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..186		4/22 (18%)
		RhoGap_RalBP1	190..371	CDD:239846	57/163 (35%)
		Mediates interaction with RALA and RALB. /evidence=ECO:0000250|UniProtKB:Q15311	403..499
		Smc	<413..>594	CDD:440809
		Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000269|PubMed:9395447, ECO:0000269|PubMed:9422736	500..647
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..550
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..647