DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP68F and Arhgap8

DIOPT Version :9

Sequence 1:	NP_001261744.1	Gene:	RhoGAP68F / 39385	FlyBaseID:	FBgn0036257	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_006521531.1	Gene:	Arhgap8 / 73167	MGIID:	1920417	Length:	480	Species:	Mus musculus

Alignment Length:	443	Identity:	161/443 - (36%)
Similarity:	223/443 - (50%)	Gaps:	43/443 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PSLSDLHDFEPKLEFDDTELLAPSPLEKDVMVGDFVLAEDPELEPEEDVNPLEDDFEDQLREQSE 92
            |..|.|.|.|..:....||  .||...   |.|     .||.|....       .|.|..|
Mouse    31 PGKSPLRDKEAAVTLGATE--GPSVAS---MAG-----LDPTLSTSH-------PFYDVAR---- 74

  Fly    93 NFQTPRNKCDFLGTDKQGRHIFGIYASRFPEKSQL--EGFVREIIKEIEPFVENDYILVYFHQGL 155
                 .......|.|:|||.||.....|.|...||  :..:..:...::..|||||.:||||.||
Mouse    75 -----HGILQVAGDDRQGRRIFTFSCCRLPPLHQLNHQRLLEYLKYTLDQHVENDYTIVYFHYGL 134

  Fly   156 KEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISDKFRKKLVYISSLDE 220
            ...||||..:|.|:|||.||.::||||.|||||||..|:.:||.|.|.||.||.||:.|.|:|.|
Mouse   135 SSQNKPSLGWLQNTYKEFDRKYKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYCSNLRE 199

  Fly   221 LRQALGLNKLKLPDNICDLDDKLNPSRKPSTPPPSSNINASRQQQHKMATTHQFGVPLKFI-VMN 284
            ||:.|..::|.:|..:...|:||....|...|||:..     ........|.||||.|::: ..|
Mouse   200 LREHLQCDQLLIPPEVVRYDEKLQNLHKGQPPPPTKT-----PPPRPPLPTQQFGVSLQYLRDKN 259

  Fly   285 SPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERVNRGEDVDLKSV-NVHVIAG 348
            ...|  |||::|..|..|...| :.|||:||||.:...:..::...::|:.|:.... ::|:.|.
Mouse   260 QGEL--IPPVLRWTVTYLREKG-LRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAV 321

  Fly   349 LLKSFLRDLAEPLLTFELYEDVTGFLDWPKEERSRNVT--QLIREKLPEENYELFKYIVEFLVRV 411
            :||:|||:|.:|||||:.||.:.|.   ...|.|..||  :||...|||.||.:.:|::.||..|
Mouse   322 ILKTFLRELPQPLLTFQAYEQILGI---TSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEV 383

  Fly   412 MDCEDLNKMTSSNLAIVFGPNFLWSRSTSTSLEEIAPINAFVDFVLQNHKDIY 464
            ......|||.|||||.|||.|.:|......||..:.|:|.|.:.:::.:..::
Mouse   384 SLESISNKMNSSNLACVFGLNLIWPSQGVASLSALVPLNLFTELLIEYYDKVF 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001261744.1	SEC14	105..233	CDD:238099	63/129 (49%)
RhoGAP68F	NP_001261744.1	RhoGAP-p50rhoGAP	269..464	CDD:239869	73/198 (37%)
Arhgap8	XP_006521531.1	CRAL_TRIO_2	87..220	CDD:372686	61/132 (46%)
Arhgap8	XP_006521531.1	RhoGAP	248..436	CDD:383032	71/193 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5572
eggNOG	1	0.900	-	-		E1_KOG4406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3057
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52084
OrthoDB	1	1.010	-	-		D1511935at2759
OrthoFinder	1	1.000	-	-		FOG0002972
OrthoInspector	1	1.000	-	-		otm42969
orthoMCL	1	0.900	-	-		OOG6_103505
Panther	1	1.100	-	-	O	PTHR45808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4738
SonicParanoid	1	1.000	-	-		X3319
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870