Protein Alignment RhoGAP68F and PRR5-ARHGAP8

DIOPT Version :10

• Sequence 1: NP_001401037.1
• Gene: RhoGAP68F / 39385
• FlyBaseID: FBgn0036257
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_851851.3
• Gene: PRR5-ARHGAP8 / 553158
• HGNCID: 34512
• Length: 564
• Species: Homo sapiens
• Alignment Length: 364
• Identity: 139/364 - (38%)
• Similarity: 207/364 - (56%)
• Gaps: 13/364 - (3%)

  Fly   114 GTDKQGRHIFGIYASRFPEKSQLE-GFVREIIK-EIEPFVENDYILVYFHQGLKEDNKPSAQFLW 176
            |.|:.||.:......|.|...:|: ..:.|.:| .::.:|||||.:||||.||...||||..:|.
Human   158 GDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQ 222

  Fly   177 NSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISDKFRKKLVYISSLDELRQALGLNKLKL 241
            ::|||.||.::||||.|||||||.||:|:||...|.||.||.||::|.:.|.||.:.|..::|.:
Human   223 SAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVI 287

  Fly   242 PDNICDLDDKLNPSRKPSTPPPSSNINASRQQQHKMATTHQFGVPLKFIV-MNSPCLNSIPPIVR 305
            |..:...|:||....:..||||:..     ........|.||||.|:::. .|...|  |||::|
Human   288 PPEVLRYDEKLQSLHEGRTPPPTKT-----PPPRPPLPTQQFGVSLQYLKDKNQGEL--IPPVLR 345

  Fly   306 KCVDSLSITGVIDTEGIFRRSGNHSEIMALKERVNRGEDVDLKSV-NVHVIAGLLKSFLRDLAEP 369
            ..|..|...| :.|||:||||.:...:..::...|:|:.|:.... ::|:.|.:||:|||:|.:|
Human   346 FTVTYLREKG-LRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQP 409

  Fly   370 LLTFELYEDVTGFLDWPKEERSRNVTQLIREKLPEENYELFKYIVEFLVRVMDCEDLNKMTSSNL 434
            ||||:.||.:.|........|.....|::| .|||.||.:.:|::.||..|......|||.||||
Human   410 LLTFQAYEQILGITCVESSLRVTGCRQILR-SLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNL 473

  Fly   435 AIVFGPNFLWSRSTSTSLEEIAPINAFVDFVLQNHKDIY 473
            |.|||.|.:|.....:||..:.|:|.|.:.:::.::.|:
Human   474 ACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIF 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001401037.1	CRAL_TRIO_2	119..242	CDD:463965	57/124 (46%)
		RhoGAP-p50rhoGAP	278..473	CDD:239869	71/196 (36%)
PRR5-ARHGAP8	NP_851851.3	CRAL_TRIO_2	163..296	CDD:463965	58/132 (44%)
		RhoGAP	322..512	CDD:470621	70/193 (36%)