DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP68F and arhgap1

DIOPT Version :9

Sequence 1:	NP_001261744.1	Gene:	RhoGAP68F / 39385	FlyBaseID:	FBgn0036257	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001008141.1	Gene:	arhgap1 / 493503	XenbaseID:	XB-GENE-1015089	Length:	435	Species:	Xenopus tropicalis

Alignment Length:	463	Identity:	152/463 - (32%)
Similarity:	239/463 - (51%)	Gaps:	66/463 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LSDLHDFEPKLEFDDTELLAPSPLEKDVMVGDFVLAEDPELEPEEDVNPLEDDFEDQLREQSENF 94
            ||||:|   .|:.|:|..|                 :..:|...:|.|...||.:|.....:::.
Frog     6 LSDLND---DLDKDETNQL-----------------DQLKLASLDDKNWPSDDVQDYPNNANDSK 50

  Fly    95 QTP-----------------RNKCDFLGTDKQGRHIFGIYASRFPEKSQLE--GFVREIIKEIEP 140
            .:|                 |...:..|.||.||.|....|.|.|...:::  ..::.:...::.
Frog    51 PSPDPVTHLRWDDPYYDIAWRQIVEVAGDDKYGRKIVVFSACRLPPCHEIDHVKLLQYLKHTLDQ 115

  Fly   141 FVENDYILVYFHQGLKEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFIS 205
            :||:||.|||.|.||..:||||..:|.::|:|.||.::||:|.||:||||.||:.:...|.|.||
Frog   116 YVESDYTLVYLHHGLTSENKPSLGWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPIIS 180

  Fly   206 DKFRKKLVYISSLDELRQALGLNKLKLPDNICDLDDKLN-------PSRKPSTP-PPSSNINASR 262
            .||.:|:.|.:.|.:|.:.:.:.:|.:|..:...||.:.       .::||..| ||..|
Frog   181 FKFGRKIFYANYLSDLEEHMKVEQLGIPKQVLKYDDLIRSNLKTSAATQKPGPPRPPLPN----- 240

  Fly   263 QQQHKMATTHQFGVPLKFIVMNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALK 327
                     .|||:.|..:....|..:.||.:||..|..|. ...:.||||||||.....:..::
Frog   241 ---------QQFGISLLHLKEKHPENDKIPLVVRDTVAFLQ-ENALSTEGIFRRSARTQIVREVQ 295

  Fly   328 ERVNRGEDVDLKSV-NVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPKEERSRNVTQLIRE 391
            ::.|.|..|..:.. :||:.|.:||:|||:|.|||||:.||..|   :|:.|:|:....|..|.:
Frog   296 QKYNMGVQVTFQQYDDVHLPAVILKTFLRELPEPLLTYNLYSFV---VDFSKQEQKIESTLQILQ 357

  Fly   392 KLPEENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGPNFLWSRSTSTSLEEIAPINAFVDFV 456
            .||:|||::.:::..|||.|....:.||||::|||:|||||.||.:..:.:|:.|.|||.|..|:
Frog   358 TLPKENYDVLQFLTAFLVEVSSHNEQNKMTTTNLAVVFGPNLLWVKDAAMTLKAINPINTFTKFL 422

  Fly   457 LQNHKDIY 464
            |.|.::::
Frog   423 LDNQRELF 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001261744.1	SEC14	105..233	CDD:238099	50/129 (39%)
RhoGAP68F	NP_001261744.1	RhoGAP-p50rhoGAP	269..464	CDD:239869	76/195 (39%)
arhgap1	NP_001008141.1	CRAL_TRIO_2	83..216	CDD:404584	48/132 (36%)
arhgap1	NP_001008141.1	RhoGAP-p50rhoGAP	240..430	CDD:239869	77/207 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20909
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3285
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1511935at2759
OrthoFinder	1	1.000	-	-		FOG0002972
OrthoInspector	1	1.000	-	-		oto103147
Panther	1	1.100	-	-	LDO	PTHR45808
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4738
SonicParanoid	1	1.000	-	-		X3319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190