DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP68F and ARHGAP1

DIOPT Version :9

Sequence 1:	NP_001261744.1	Gene:	RhoGAP68F / 39385	FlyBaseID:	FBgn0036257	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_004299.1	Gene:	ARHGAP1 / 392	HGNCID:	673	Length:	439	Species:	Homo sapiens

Alignment Length:	460	Identity:	168/460 - (36%)
Similarity:	250/460 - (54%)	Gaps:	57/460 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LSDLHDFEPKLEFDDT-----ELLAPSPLEK----DVMVGDFVLAEDPELEPEEDVNPL--EDDF 83
            ||:|.|   .|..|||     :|...|..||    |.| .||..::|.:....|.|..|  :|.:
Human     4 LSELQD---DLTLDDTSEALNQLKLASIDEKNWPSDEM-PDFPKSDDSKSSSPELVTHLKWDDPY 64

  Fly    84 EDQLREQSENFQTPRNKCDFLGTDKQGRHIFGIYASRFPEKSQLE-----GFVREIIKEIEPFVE 143
            .|..|.|.         .:..|.||.||.|....|.|.|...||:     |:::.   .::.:||
Human    65 YDIARHQI---------VEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKH---TLDQYVE 117

  Fly   144 NDYILVYFHQGLKEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISDKF 208
            :||.|:|.|.||..|||||..:|.::|:|.||.::||:|.||:||||.||:.:...|.|.||.||
Human   118 SDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKF 182

  Fly   209 RKKLVYISSLDELRQALGLNKLKLPDNICDLDDKLNPSR-------KPSTP-PPSSNINASRQQQ 265
            .:|:.|::.|.||.:.:.|.:|.:|..:...||.|..::       ||..| ||..|
Human   183 GQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPN-------- 239

  Fly   266 HKMATTHQFGVPLKFIVMNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERV 330
                  .||||.|:.:...:|....||.::|:.|..|. ...:.||||||||.|...:..::::.
Human   240 ------QQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQ-AHALTTEGIFRRSANTQVVREVQQKY 297

  Fly   331 NRGEDVDLKSVN-VHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPKEERSRNVTQLIREKLP 394
            |.|..||....| :|:.|.:||:|||:|.||||||:||..|.|||:..:.:|.....|:: :.||
Human   298 NMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVL-QTLP 361

  Fly   395 EENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGPNFLWSRSTSTSLEEIAPINAFVDFVLQN 459
            ||||::.:::..|||::....|.||||::|||:|||||.||::..:.:|:.|.|||.|..|:|.:
Human   362 EENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDH 426

  Fly   460 HKDIY 464
            ..:::
Human   427 QGELF 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001261744.1	SEC14	105..233	CDD:238099	55/132 (42%)
RhoGAP68F	NP_001261744.1	RhoGAP-p50rhoGAP	269..464	CDD:239869	79/195 (41%)
ARHGAP1	NP_004299.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..52		7/24 (29%)
		CRAL_TRIO_2	82..206	CDD:338915	52/126 (41%)
		SH3-binding	228..238		5/9 (56%)
		RhoGAP-p50rhoGAP	239..431	CDD:239869	80/207 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5646
eggNOG	1	0.900	-	-		E1_KOG4406
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20909
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3119
Isobase	1	0.950	-	0	Normalized mean entropy	S2980
OMA	1	1.010	-	-		QHG52084
OrthoDB	1	1.010	-	-		D1511935at2759
OrthoFinder	1	1.000	-	-		FOG0002972
OrthoInspector	1	1.000	-	-		otm40896
orthoMCL	1	0.900	-	-		OOG6_103505
Panther	1	1.100	-	-	LDO	PTHR45808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4738
SonicParanoid	1	1.000	-	-		X3319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820