DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP68F and Prr5

DIOPT Version :9

Sequence 1:	NP_001261744.1	Gene:	RhoGAP68F / 39385	FlyBaseID:	FBgn0036257	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001012121.1	Gene:	Prr5 / 315189	RGDID:	1307954	Length:	387	Species:	Rattus norvegicus

Alignment Length:	290	Identity:	55/290 - (18%)
Similarity:	100/290 - (34%)	Gaps:	86/290 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 VENDYILVYFHQGLKEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISD 206
            :.|..|.|:..:||.:..    .|:      |:...|:.|||           .:.:||:.::.:
  Rat    47 IHNGVIAVFQRKGLPDQE----LFI------LNEGVRQLLKT-----------ELGSFFTEYLQN 90

  Fly   207 KFRKKLVYISSLDELRQALGLNKLKLPDNICDLDDKLNPSRKPSTPPPSSNINASRQQQHKMATT 271
            :...|.:.|.. |::|...|   .||.|::.:..|.......|:.......:........::|..
  Rat    91 QLLTKGMVILR-DKIRFYEG---QKLLDSLAETWDFFFSDVLPTLQAIFYPVQGKEPSVRQLALL 151

  Fly   272 H-----QFGVPLKFIVMNS-PCLNSIPPIVRKCVDSLSITGV----------------------- 307
            |     ...|.|:..:..| .|   :||.:.:.:  |.:.||
  Rat   152 HFRNTITLSVKLEDALARSHAC---VPPAIAQML--LVLQGVHESRGVTEDYLRLETLIQKVVSP 211

  Fly   308 -IDTEGIFRRSG--NHSEIMALKERVNRGEDVDLKSVNVHVIAGLLKSFLRDLAEPLLTFEL--- 366
             :.|.|::...|  .||.|:. |..:.|....|:.:.|..|.:   ||:...|..|:...|.
  Rat   212 YLGTYGLYSNEGPCTHSCILE-KRFLRRSRSGDILAKNPVVRS---KSYNTPLLNPVAEHEAEGT 272

  Fly   367 -----------YEDVT------GFLDWPKE 379
                       ..::|      ||:|.|.:
  Rat   273 ASGGTSIRRHSVSEMTSCPEPQGFVDTPDQ 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001261744.1	SEC14	105..233	CDD:238099	19/90 (21%)
RhoGAP68F	NP_001261744.1	RhoGAP-p50rhoGAP	269..464	CDD:239869	32/163 (20%)
Prr5	NP_001012121.1	Interaction with RICTOR. /evidence=ECO:0000250\|UniProtKB:P85299	10..96		13/69 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..33
		HbrB	40..159	CDD:285710	25/136 (18%)
		Interaction with RICTOR. /evidence=ECO:0000250\|UniProtKB:P85299	189..219		2/29 (7%)
		PHA03326	<224..326	CDD:223045	18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..347		7/41 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..387
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4406
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900