DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP68F and ARHGAP8

DIOPT Version :9

Sequence 1:	NP_001261744.1	Gene:	RhoGAP68F / 39385	FlyBaseID:	FBgn0036257	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001017526.1	Gene:	ARHGAP8 / 23779	HGNCID:	677	Length:	464	Species:	Homo sapiens

Alignment Length:	395	Identity:	139/395 - (35%)
Similarity:	207/395 - (52%)	Gaps:	44/395 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GTDKQGRHIFGIYASRFPEKSQLE-GFVREIIK-EIEPFVENDYILVYFHQGLKEDNKPSAQFLW 167
            |.|:.||.:......|.|...:|: ..:.|.:| .::.:|||||.:||||.||...||||..:|.
Human    27 GDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQ 91

  Fly   168 NSYKELDR-------------------------------NFRKNLKTLYVVHPTWFIRVIWNFFS 201
            ::|||.||                               .::||||.|||||||.||:|:||...
Human    92 SAYKEFDRKDGDLTMWPRLVSNSKLKRSSHLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILK 156

  Fly   202 PFISDKFRKKLVYISSLDELRQALGLNKLKLPDNICDLDDKLNPSRKPSTPPPSSNINASRQQQH 266
            |.||.||.||::|.:.|.||.:.|..::|.:|..:...|:||....:..||||:..     ....
Human   157 PLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKT-----PPPR 216

  Fly   267 KMATTHQFGVPLKFIV-MNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERV 330
            ....|.||||.|:::. .|...|  |||::|..|..|...| :.|||:||||.:...:..::...
Human   217 PPLPTQQFGVSLQYLKDKNQGEL--IPPVLRFTVTYLREKG-LRTEGLFRRSASVQTVREIQRLY 278

  Fly   331 NRGEDVDLKSV-NVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPKEERSRNVTQLIREKLP 394
            |:|:.|:.... ::|:.|.:||:|||:|.:|||||:.||.:.|........|.....|::| .||
Human   279 NQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILR-SLP 342

  Fly   395 EENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGPNFLWSRSTSTSLEEIAPINAFVDFVLQN 459
            |.||.:.:|::.||..|......|||.|||||.|||.|.:|.....:||..:.|:|.|.:.:::.
Human   343 EHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEY 407

  Fly   460 HKDIY 464
            ::.|:
Human   408 YEKIF 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001261744.1	SEC14	105..233	CDD:238099	59/160 (37%)
RhoGAP68F	NP_001261744.1	RhoGAP-p50rhoGAP	269..464	CDD:239869	71/196 (36%)
ARHGAP8	NP_001017526.1	SEC14	12..188	CDD:238099	59/160 (37%)
		RhoGAP	222..412	CDD:295372	70/193 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5646
eggNOG	1	0.900	-	-		E1_KOG4406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3119
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52084
OrthoDB	1	1.010	-	-		D1511935at2759
OrthoFinder	1	1.000	-	-		FOG0002972
OrthoInspector	1	1.000	-	-		otm40896
orthoMCL	1	0.900	-	-		OOG6_103505
Panther	1	1.100	-	-	O	PTHR45808
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880