DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP68F and Sh3bp1

DIOPT Version :10

Sequence 1:NP_001401037.1 Gene:RhoGAP68F / 39385 FlyBaseID:FBgn0036257 Length:485 Species:Drosophila melanogaster
Sequence 2:NP_001303613.1 Gene:Sh3bp1 / 20401 MGIID:104603 Length:680 Species:Mus musculus


Alignment Length:452 Identity:106/452 - (23%)
Similarity:193/452 - (42%) Gaps:114/452 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 EFDDTELLAPSPLEKDVMVGDFVLAED--PE-LEPEEDVNPLEDDF---EDQLREQSENFQTPRN 108
            ||:.|       ||:||:.....|:|:  |. |:.::.:..|..|:   :.:|.:.::|..:.:.
Mouse   114 EFEMT-------LERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQAAKNSGSNQG 171

  Fly   109 KCDFLGTDKQGRHIFGIYASRFPEKSQLEGFVREIIKEIEPFVENDYILVYFHQGLKEDNKPSAQ 173
                || ...|.|.....|::.....:.|   .|:.|::|. .:::|:...:|...|||:     
Mouse   172 ----LG-GASGSHTHTTTANKVEMLKEEE---EELKKKVEQ-CKDEYLADLYHFSTKEDS----- 222

  Fly   174 FLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISDKFRKKLVYI-SSLDELRQALGLN 237
                                   :..:||.::     ...:|..||.|..: ::|.|||      
Mouse   223 -----------------------YANYFIHLL-----EIQADYHRKSLTSLDTALAELR------ 253

  Fly   238 KLKLPDNICDLDDKLNPSRKP-STPPPSSNINASRQQQHKMATTHQFGVPLKFIVMNSPCLNSIP 301
                 ||....|      ..| :|..|.|.:.....:.|.........:|::..|:         
Mouse   254 -----DNHSQAD------HSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVL--------- 298

  Fly   302 PIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERV-NRGEDVDLKSVNVHVIAGLLKSFLRD 365
                     |.::..:..||:||.:...|.:..||:.: :....::....:.|.:||.|||:||:
Mouse   299 ---------LLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRE 354

  Fly   366 LAEPLLTFELYEDVTGFLDWP-----KEERSR-NVTQLIREKLPEENYELFKYIVEFLVRVMDCE 424
            |.|||:|.:||:      ||.     ||..:| .....:..:||:||:...:|:::||..:.:.:
Mouse   355 LPEPLMTSDLYD------DWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQ 413

  Fly   425 DLNKMTSSNLAIVFGPNFLW--------SRSTSTSLEEIAPINAFVDFVLQNHKDIYLIDVN 478
            |:||||.||:|||.|||.||        ::..:.|:..|..:.. |:.::||...::..|:|
Mouse   414 DVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGV-VEALIQNADTLFPGDIN 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP68FNP_001401037.1 CRAL_TRIO_2 119..242 CDD:463965 22/123 (18%)
RhoGAP-p50rhoGAP 278..473 CDD:239869 57/209 (27%)
Sh3bp1NP_001303613.1 Interaction with CGNL1. /evidence=ECO:0000250|UniProtKB:Q9Y3L3 1..275 46/226 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
BAR_SH3BP1 16..275 CDD:153304 46/226 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..184 5/28 (18%)
RhoGAP 272..473 CDD:470621 58/225 (26%)
Interaction with CD2AP. /evidence=ECO:0000250|UniProtKB:Q9Y3L3 470..680 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..680
SH3-binding. /evidence=ECO:0000269|PubMed:8438166 607..616
Blue background indicates that the domain is not in the aligned region.

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