Protein Alignment RhoGAP68F and tag-325

DIOPT Version :10

• Sequence 1: NP_001401037.1
• Gene: RhoGAP68F / 39385
• FlyBaseID: FBgn0036257
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001309440.1
• Gene: tag-325 / 175636
• WormBaseID: WBGene00008006
• Length: 840
• Species: Caenorhabditis elegans
• Alignment Length: 560
• Identity: 120/560 - (21%)
• Similarity: 204/560 - (36%)
• Gaps: 142/560 - (25%)

  Fly    22 RPAINPIVDNSD---EPQPS-------------------LSDLHDFEPKLEFDDTELLA------ 58
            :|....|..:||   ||.|:                   :|......|:.:.:||:.||
 Worm   232 KPIEGSIASDSDFDEEPVPTSSRKASTASGVMMPHPYAHVSSFQSTFPRAKNEDTDKLASYVIPP 296

  Fly    59 ----------------PSPLE-------------KDVMVGDFVLAEDPELEPEEDVNP-LEDDFE 93
                            |||..             |:|.:...:    |......|.:| ...:..
 Worm   297 DANETSKTPTAIRVRRPSPTNLRSVSFQNKCTVLKNVPMPQVL----PTTSSSFDHHPQYHSNTP 357

  Fly    94 DQ--LREQSENFQTPRNKCDFLGTDKQGRHIFGIYASRFPEKSQLEGFVREIIK-EIEPFVENDY 155
            |:  |.|.|.:| ||.::|:.......||...........|:|:.:....:::| :...::.|..
 Worm   358 DRPILMEDSADF-TPSSRCEERRGSGDGREPVRTIRCGDLERSENDEPAEKVVKPKKREWITNYM 421

  Fly   156 ILVYFHQGLKEDNK---------PSAQFLWN------SYKELDRNFRK------------NLKTL 193
            .|...|..|.:|.|         .:.|.:|:      ::.:.:|:.:|            |.|..
 Worm   422 YLTTAHLILYKDQKSAEKHGKHYDAPQGVWDLRGASVTWYQDNRDVQKKKQRKYIQLELCNTKKY 486

  Fly   194 YVVHPT------WF---IRVIWNFFSPFISDK--------FRKKLVYISSLDELRQALGLNKLKL 241
            .:..|.      |:   ..|:....||..|::        ..:...||.|...|..||    :.:
 Worm   487 LLRGPNDTEAVEWYKSLEEVVAKLPSPGSSNQPMIDVTNGVARNPSYIGSTRPLSHAL----IPI 547

  Fly   242 PDNICDLDDKLNPSR--------KPSTPPPSSN--INASRQQQHKMATTHQ------------FG 284
            ..::...||.::.|.        ....|.||..  |...|:......|...            ||
 Worm   548 SRSMRRRDDPMSQSAIETVSTSVSTDEPRPSKETIIEKLRRFFRTRPTVESLKEKGIYKPEPVFG 612

  Fly   285 VPLKFIVMNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERVNRGEDVDLKS 349
            ..|..|..:...|  :|..:|...:.:...| ::|:||:|.|||.|.:..::.:.::.....|.|
 Worm   613 STLSAICQHENSL--VPKFIRVITEVIESKG-LETDGIYRVSGNLSAVQKIRCQADQDNYKALVS 674

  Fly   350 -VNVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPK-EERSRNVTQLIREKLPEENYELFKY 412
             .::||:.|.||.|.|:|.:||....|:::.|..:..|. ..|.:...:|: .:||.||.|..|.
 Worm   675 EEDIHVLTGALKLFFRELTDPLFPISLHKEYTSAMQMPNATTRFKKFEELL-SRLPNENRETLKM 738

  Fly   413 IVEFLVRVMDCEDLNKMTSSNLAIVFGPNFLWSRSTSTSL 452
            ::..|.||......|:|...||||||||....:...:.:|
 Worm   739 LLRHLNRVASHSSQNRMQQHNLAIVFGPTLFHNGDGAVNL 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001401037.1	CRAL_TRIO_2	119..242	CDD:463965	29/167 (17%)
		RhoGAP-p50rhoGAP	278..473	CDD:239869	54/189 (29%)
tag-325	NP_001309440.1	WW	104..130	CDD:459800
		PH_ARHGAP9-like	391..509	CDD:270053	18/117 (15%)
		RhoGAP_ARHGAP27_15_12_9	611..825	CDD:239868	53/172 (31%)