Protein Alignment RhoGAP68F and CHN2

DIOPT Version :10

• Sequence 1: NP_001401037.1
• Gene: RhoGAP68F / 39385
• FlyBaseID: FBgn0036257
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: XP_047275795.1
• Gene: CHN2 / 1124
• HGNCID: 1944
• Length: 514
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 126/558 - (22%)
• Similarity: 200/558 - (35%)
• Gaps: 177/558 - (31%)

  Fly    35 PQPSLSDLH----------------------DFEPKLEFDDTELLAPSPLEKDVMVGDFVLAEDP 77
            ||.:||.|.                      |.:..|:|..|               |:.|.||
Human    15 PQTALSSLRLLVTVTSLSLHHAPLSFPHSAPDTQASLQFPQT---------------DYKLLED- 63

  Fly    78 ELEPEEDVNPLEDDFEDQLREQSENFQTPRNKCDFLGTDKQ------GRHIFGIYASRFPEKSQL 136
               .||...|:...:..||::::     ||.|......:.:      ||...||.:
Human    64 ---AEEYQPPIWKSYLYQLQQEA-----PRPKRIICPREVENRPKYYGREFHGIIS--------- 111

  Fly   137 EGFVREIIKEIEPFVENDYILVYFHQGLKEDNKPSAQFLWNSYKELDRNFR-------------- 187
                ||...|:...||..|||      .:...:|....|...:.....|:|
Human   112 ----REQADELLGGVEGAYIL------RESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF 166

  Fly   188 --------KNLKTLYVVHPT--WFIRVIWN------FFSPFISDKFRKKL--------------- 221
                    ..|.|||:....  :..::..|      .::..:.:|..::|
Human   167 ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHE 231

  Fly   222 -----VYISSLDELRQALGLNKLKLPDNICDLDD----KLNPSRKPSTPPPSSNINASRQQQ--- 274
                 ..||||.. |.||..|     ||..:.:.    |::..|.|......:|.......|
Human   232 EHTAVEKISSLVR-RAALTHN-----DNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVR 290

  Fly   275 --------HKMATTHQFGVP------LKFIVMNSPC-LNSI--------PPIVRKCVDSLSITGV 316
                    ||..:.|   ||      ||.|.....| |.::        |.:|..|:..:...|
Human   291 CSDCGLNVHKQCSKH---VPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARG- 351

  Fly   317 IDTEGIFRRSGNHSEIMALKERVNR-GEDVDLKSVNVH----VIAGLLKSFLRDLAEPLLTFELY 376
            :.:||::|.||....|..:|...:| ||..|: |.||:    :|.|.||.:.|||..|::|::.|
Human   352 LKSEGLYRVSGFTEHIEDVKMAFDRDGEKADI-SANVYPDINIITGALKLYFRDLPIPVITYDTY 415

  Fly   377 EDVTGFLDWPK----EERSRNVTQLIREKLPEENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIV 437
               :.|:|..|    :||...|.:::. .||..:||..:|::..|.:|...|..|.|.:.||.||
Human   416 ---SKFIDAAKISNADERLEAVHEVLM-LLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIV 476

  Fly   438 FGPNFLW--SRSTSTSLEEIAPINAFVDFVLQNHKDIY 473
            |||..:.  ..||.|:|.::......|..:::|...::
Human   477 FGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP68F	NP_001401037.1	CRAL_TRIO_2	119..242	CDD:463965	31/172 (18%)
		RhoGAP-p50rhoGAP	278..473	CDD:239869	65/220 (30%)
CHN2	XP_047275795.1	SH2_a2chimerin_b2chimerin	98..184	CDD:198215	20/104 (19%)
		C1_betaCHN	256..316	CDD:410407	11/62 (18%)
		RhoGAP_chimaerin	321..514	CDD:239837	59/198 (30%)