Protein Alignment DEF8 and Def8

DIOPT Version :10

• Sequence 1: NP_648549.1
• Gene: DEF8 / 39381
• FlyBaseID: FBgn0046296
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_001401209.1
• Gene: Def8 / 23854
• MGIID: 1346331
• Length: 499
• Species: Mus musculus
• Alignment Length: 388
• Identity: 146/388 - (37%)
• Similarity: 224/388 - (57%)
• Gaps: 23/388 - (5%)

  Fly    80 LIFTSDANIQDLQAAIAHCRDLVLLSEELSEERRWLVRHLVDLRYSLQELEEAQEQHSLSSDMVV 144
            |...||  :|.|:.||..|:.::|...|.||:::..|..|:.||..||||::..|:..
Mouse   124 LFLASD--VQQLRQAIEECKQVILELPEQSEKQKDAVVRLIHLRLKLQELKDPNEEEP------- 179

  Fly   145 MNAIRAVVGHHFVPHHPHHGKRNRLQAAAKRNYCDHCTTIIWSVVQNSYVCSDCGFLVHQKCIDG 209
              .||.::.|.|.          :.::.:.:..||.|.||||.::|..|.|:.|.:..|.||::.
Mouse   180 --NIRVLLEHRFY----------KEKSKSVKQTCDKCNTIIWGLIQTWYTCTGCCYRCHSKCLNL 232

  Fly   210 VKRVCAHVLVSERQHPISEICPEIGLASQGYKCAECGTMLNIKNTWIEPRLCDYSGLYYCPRCNW 274
            :.:.|....||.:......||||.||.||.|:||||...::::....|.|.|||:|.|||..|:|
Mouse   233 ISKPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRGVPSEARQCDYTGQYYCSHCHW 297

  Fly   275 NDSNFIPARIIHNWDFSPRRVSRTALQEIRLFLNKPLIRLEEDNPKLFVFVEKLCAVKKLRQNLV 339
            ||...||||::|||||.||:|||.:::.:.|.:::|::||.|.||.||.:||:|..::||||:::
Mouse   298 NDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPVLRLREINPLLFNYVEELVEIRKLRQDIL 362

  Fly   340 HMRHYLAACKIASELKLVDQQLGVRRHLAQSNEFYSLSDLSQVESGALSEFLQGVFKAFNDHIR- 403
            .|:.|...||.|.|.:|: .||..|:|..:::|.||:.||.:|..|.||..|..:...|..||:
Mouse   363 LMKPYFITCKEAMEARLL-LQLQDRQHFVENDEMYSIQDLLEVHMGRLSCSLTEIHTLFAKHIKL 426

  Fly   404 SCPMCLAQAYICEICSNNEVIFPFDDGCIKCDQCNSIFHRVCLTRKNMICPKCIRIQERRLQL 466
            .|..|.|:.::||:|...:|:||||.....|:.|:::|||.|....:..||||.|:..|:..|
Mouse   427 DCERCQAKGFVCELCKEGDVLFPFDSHTSVCNDCSAVFHRDCYYDNSTTCPKCARLTLRKQSL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DEF8	NP_648549.1	C1_DEF8	<173..219	CDD:410369	15/45 (33%)
		zf-RING_9	259..461	CDD:464030	88/202 (44%)
Def8	NP_001401209.1	C1_DEF8	182..242	CDD:410369	18/69 (26%)
		zf-RING_9	282..482	CDD:464030	87/200 (44%)