Protein Alignment DEF8 and F20H11.1

DIOPT Version :10

• Sequence 1: NP_648549.1
• Gene: DEF8 / 39381
• FlyBaseID: FBgn0046296
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_498454.2
• Gene: F20H11.1 / 175933
• WormBaseID: WBGene00017646
• Length: 486
• Species: Caenorhabditis elegans
• Alignment Length: 450
• Identity: 136/450 - (30%)
• Similarity: 219/450 - (48%)
• Gaps: 60/450 - (13%)

  Fly    76 EQWRLIFTSDANIQDLQAAIAHCRDL---VLLSEELSE--------------------ERRWLVR 117
            :.||....::.:::.::||:.:|||.   :|:.||.:|                    |.|.::.
 Worm    45 DDWRRSNEAENHVECIKAALEYCRDKLKELLIDEEDTEMDGKETKTKPINIVSNTEFPEDRDVLG 109

  Fly   118 HLVDLRYSLQELEEAQ-----------EQHSLSSDMVV-----MNAIRAVVGHHFVPHHPHHGKR 166
            :||:.....|:....|           |:.:|..:.||     ::..|| .||.|| ..|..|..
 Worm   110 NLVNCLDRQQKAARQQMYFDKIVQLGLERQALQDEAVVSTSSPLDECRA-EGHEFV-MQPVRGGH 172

  Fly   167 NRLQAAAKRNYCDHCTTIIWSVVQNSYVCSDCGFLVHQKCIDGVKRVCAHVLVSERQHPI-SEIC 230
            |..        |:.|...||.:||....|..||...|.||.:.||||||.||.:..:..: :.:|
 Worm   173 NPC--------CEVCMHTIWRLVQWWRRCRVCGMRAHDKCAEEVKRVCAGVLSTRAKFELNTNLC 229

  Fly   231 PEIGLASQGYKCAECGTMLNIKN-TWIEPRLCDYSGLYYCPRCNWNDSNFIPARIIHNWDFSPRR 294
            .|..||.|.|:||||...:.... ...|.|||||||..:||.|:|||...|||||:||.|.:||.
 Worm   230 EERSLAEQEYQCAECTAPICFDGVAEQEARLCDYSGELFCPNCHWNDVWSIPARIVHNLDSTPRP 294

  Fly   295 VSRTALQEIRLFLNKPLIRLEEDNPKLFVFVEKLCAVKKLRQNLVHMRHYLAACKIASELKLVDQ 359
            |.|...|.:.:..::|||.:.|....|..|.::|..|.:||:|.:.|:.|..:|:.|..|::: |
 Worm   295 VCRAVKQLLAIIDHRPLIDINESTLSLIKFHKELRRVNELRRNFLLMKCYFVSCRTARRLRIL-Q 358

  Fly   360 QLGVRRHLAQSNEFYSLSDLSQVESGALSEFLQGVFKAFNDHI-RSCPMCLAQAYICEICSN--- 420
            .|....|...::..||..:|.::..|.|...|:.:...|..|| ..|..|....:.||:|.:
 Worm   359 YLNAHSHFVDNSVMYSPKELRELCDGTLLPDLEQIHTVFRKHIEEECETCAGNGFFCELCDDINV 423

  Fly   421 ---NEVIFPFDDGCIKCDQCNSIFHRVCLTRKNMICPKCIRIQERRLQLDRMKSTEDDDD 477
               |::::||.:....|..|.:::|:.|..||::.||:|.| :.:|.::.:..|:.|:.:
 Worm   424 DQKNKILYPFTENTRSCATCLAVYHKKCFERKSLNCPRCER-RRKRTEIPKTLSSSDEKE 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DEF8	NP_648549.1	C1_DEF8	<173..219	CDD:410369	19/45 (42%)
		zf-RING_9	259..461	CDD:464030	72/208 (35%)
F20H11.1	NP_498454.2	C1_DEF8	160..216	CDD:410369	25/64 (39%)
		zf-RING_9	259..467	CDD:464030	72/209 (34%)