DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snrkb and par-1

DIOPT Version :9

Sequence 1:	NP_957127.1	Gene:	snrkb / 393806	ZFINID:	ZDB-GENE-040426-1724	Length:	741	Species:	Danio rerio
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	211/727 - (29%)
Similarity:	327/727 - (44%)	Gaps:	134/727 - (18%)

- Green bases have known domain annotations that are detailed below.

Zfish    14 GLYDLDRTLGKGHFAVVKLARHVFTGQLVAVKVIDKTKLDDLATGHLLQEVRCMKLVQHPNVVRL 78
            |.|.|.:|:|||:||.||||:|:.||:.||:|:||||:|:..:...|.:|||.||::.|||:|:|
  Fly   251 GKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKL 315

Zfish    79 YEVIDTQTKLYLILELGDGGDMYDYILRHEGGVAEDTAKVHFAQIVRAIAYCHRLHVVHRDLKPE 143
            ::||:|:..||||:|...||:::||::.| |.:.|..|:|.|.|||.|:.|||:..::|||||.|
  Fly   316 FQVIETEKTLYLIMEYASGGEVFDYLVLH-GRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAE 379

Zfish   144 NVVFFRQQGTVKLTDFGFSNHFKPGTMLMTSCGSLAYSAPEILLGEEYDAPAVDIWSLGVILYML 208
            |:: ...:..:|:.||||||.|.||:.|.|.|||..|:|||:..|::||.|.||:||||||||.|
  Fly   380 NLL-LDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 443

Zfish   209 VCGHPPFQETNDSETLIMIMDCRYTVPNHISAQCKDLISRMLQRDPAKRASLAEIESHPWLQGVD 273
            |.|..||..:...|....::..:|.:|.::|..|::|:.:.|..:|||||||..|....|:.
  Fly   444 VSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMN--- 505

Zfish   274 PSPAGF---TAAPLTSHRSLLPEEHEFILQAMTSGSIAGRDAIQEALEADRYNHITATYYLLGER 335
               .||   ...|....::.|.:...  ::|:.:... .|..|:.:|...||:.:.|||.|||.:
  Fly   506 ---MGFEEDELKPYIEPKADLADPKR--IEALVAMGY-NRSEIEASLSQVRYDDVFATYLLLGRK 564

Zfish   336 LLRDKQEQSSLTPEQRNTQRPISEPLDLVSQVPRTDTLRGTPLSALAPLGSLSTGYVRRGVSESG 400
                     |..||...::...|..|..:|         |....|.|...|:.:. ..|||..|.
  Fly   565 ---------STDPESDGSRSGSSLSLRNIS---------GNDAGANAGSASVQSP-THRGVHRSI 610

Zfish   401 DLLAPKANRHDNSFSDFCSTA--------------PCLSLNMRPLPPDQPTVKSLGALQQICEEE 451
            ...:.|.:|..:|.....:.|              |..:.|......|:.:|.|....|...:..
  Fly   611 SASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSA 675

Zfish   452 EEEDEVKVKMAPGKLGPLPSTDLSLKPSRTSLQSEPQMRTGRHSSKGMGN-------------CE 503
            ..::.. .::|.....|..:|...|..:.|:|.|..:.||........||             ..
  Fly   676 TIKENT-ARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRST 739

Zfish   504 TLAEEEEELEEGSESIEEHK--KPLDLVSSISSGTVEHQVEMPPKTEPQVEEF--------NHT- 557
            ||.|:....|:.:....|..  ..|.:.|::.|.  .|.    |:..|....|        |:|
  Fly   740 TLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSS--RHF----PRNVPSRSTFHSGQTRARNNTA 798

Zfish   558 -------------KQPGKGNDKSVFTHVSLSLEEQEGEEIQGPNVDGPLPAPRLDVVQCCWGQRE 609
                         ..||:   .|.|:.:|....::       |.:......||  |::..|..:.
  Fly   799 LEYSGTSGASGDSSHPGR---MSFFSKLSSRFSKR-------PTIADEAAKPR--VLRFTWSMKT 851

Zfish   610 PS-----------KDILENNNNTLAKSRLLEAGVISTPCGSPRS------------LPRNHCVDL 651
            .|           :::|:.||....:.   |..|:....|.|.:            |||     |
  Fly   852 TSPLMPDQIMQKIREVLDQNNCDYEQR---ERFVLWCVHGDPNTDSLVQWEIEVCKLPR-----L 908

Zfish   652 GPDGVEMRKTVG 663
            ..:||..::..|
  Fly   909 SLNGVRFKRISG 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snrkb	NP_957127.1	STKc_SNRK	12..269	CDD:270976	120/254 (47%)
		S_TKc	16..269	CDD:214567	119/252 (47%)
		UBA_SNRK	290..335	CDD:270524	13/44 (30%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/253 (47%)
		S_TKc	253..504	CDD:214567	119/252 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	11/40 (28%)
		MARK1-3_C	839..936	CDD:213381	19/92 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910