DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68b and grik4

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	361	Identity:	68/361 - (18%)
Similarity:	116/361 - (32%)	Gaps:	126/361 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 YGRCLPNGNYTGVVSDIVGGHTHFA-------PNSRFVLDCIWP----AVEVLYPYTRRNLHLVV 298
            ||....||.:||:|.:::......|       .....|:|...|    .:.::|     .:|:
Zfish   473 YGVPGANGTWTGMVGELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIMY-----RVHI-- 530

  Fly   299 PASAIQPEYLIFVRVFRRTVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWYEILEMFG 363
               ..:|.|..|:..|...||..:|:..|.|..|.:::.||.           ...||.
Zfish   531 ---GRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLT-----------PYEWYN------ 575

  Fly   364 KTHVGEPA--GRLS------SFSSMRTFLMG----------------------WILFSYVLSTIY 398
                ..|.  ||.|      |..:...|.:|                      |..|:.::.:.|
Zfish   576 ----PHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSY 636

  Fly   399 FAKLESGFVRPSYEEQVDRVDDLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIAT 463
            .|.|.:.......|..::.||||               |.::|:   :||.:..       |...
Zfish   637 TANLAAFLTVQRMEVPIESVDDL---------------ADQTAI---EYGTMHG-------GSTM 676

  Fly   464 SYYQPVVRRRDRRAAFIMRDFHARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHR 528
            :::|....:..:|....|.......|:..|.:.        |||.
Zfish   677 TFFQNSRYQTYQRMWNFMYSKQPSVFVKSTEEG--------IARV-------------------- 713

  Fly   529 LESLYSGFLEHGFFEHWRQMDL-ITRVGASPDAEEF 563
            |.|.|:..||....|::||.:. :|::|...|.:.:
Zfish   714 LNSNYAYLLESTMNEYYRQRNCNLTQIGGLLDTKGY 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	45/262 (17%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	68/361 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930