DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68b and Gria1

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_113796.1	Gene:	Gria1 / 50592	RGDID:	621531	Length:	907	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	125/753 - (16%)
Similarity:	228/753 - (30%)	Gaps:	248/753 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AVEQNVQVTYLYRCASCPASFDADYSALELDLYR---------CVGSRLPVITRNMEAHE----- 77
            |.|:|.|||    ..:...:.:..|..|..||.:         |...||..|...:...|
  Rat   165 AAEKNWQVT----AVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIG 225

  Fly    78 --------------LEPFRRTD-SLSIFQIPAAEKGDSLVRRILDMLNPHQRRKHMH------KY 121
                          |..|:.:. :::.||:  ....|::..||:........|.|..      ||
  Rat   226 YHYILANLGFMDIDLNKFKESGANVTGFQL--VNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKY 288

  Fly   122 LFVWPNAGRHQLLRLFRGSWAKKLLYGLAITGRENGTFDFDPFAWGGLQVIQR---------LDG 177
            .......|...:...|:....:::  .::..|............||....|||         |.|
  Rat   289 TSALTYDGVKVMAEAFQSLRRQRI--DISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTG 351

  Fly   178 EVPYARKVKDLRGYPLRFSMFTDPLMAMPRSPVETAGYQAVD------GVAARVVGEMLNASV-- 234
            .|.:..|.        |.:.:|..::.|....:...||...|      ...|:..|:  |:||
  Rat   352 NVQFNEKG--------RRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGD--NSSVQN 406

  Fly   235 -TYVFP-----------------EDNESY-GRC-------------------LPNGNY------- 254
             ||:..                 |.|:.| |.|                   :.:|.|
  Rat   407 RTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDT 471

  Fly   255 ---TGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVV--PASAIQPEYLIFVRVF 314
               .|:|.::|.|....|.....:.......::...|:....:.:::  |..: :|....|:...
  Rat   472 KAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS-KPGVFSFLDPL 535

  Fly   315 RRTVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWY-EILEMFGKTHVGEPAGRLSSFS 378
            ...:|..::...:.|.:|.:::.|..           ...|: |..|........:.:.....|:
  Rat   536 AYEIWMCIVFAYIGVSVVLFLVSRFS-----------PYEWHSEEFEEGRDQTTSDQSNEFGIFN 589

  Fly   379 SMRTFLMG----------------------WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDL 421
            |: .|.:|                      |..|:.::.:.|.|.|.:..........::..:||
  Rat   590 SL-WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 653

  Fly   422 VHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIMRDFHA 486
                              :..||..||.||..|                          .::|..
  Rat   654 ------------------AKQTEIAYGTLEAGS--------------------------TKEFFR 674

  Fly   487 RDFLAI-----TYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHRLESLYSGFLEHGFFEHWR 546
            |..:|:     ||...||...:  .|.....||  .:......:.:.|||..:.::|.      |
  Rat   675 RSKIAVFEKMWTYMKSAEPSVF--VRTTEEGMI--RVRKSKGKYAYLLESTMNEYIEQ------R 729

  Fly   547 QMDLITRVGASPDAEEF--------------------LEDLG-----------DQTDTDSGSNEL 580
            :.....:||.:.|::.:                    |.:.|           |:.:..||..:
  Rat   730 KPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD- 793

  Fly   581 AIRNKKVVLTLDILQGAFYLWSVGIGISCLGFAVEHAH 618
             .::|...|:|..:.|.||:...|:|::.|...:|..:
  Rat   794 -SKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	52/332 (16%)
Gria1	NP_113796.1	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	44/242 (18%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	64/447 (14%)
		Glutamate binding. /evidence=ECO:0000250	492..494		0/1 (0%)
		Glutamate binding. /evidence=ECO:0000250	668..669		1/26 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930