DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68b and clumsy

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	693	Identity:	126/693 - (18%)
Similarity:	216/693 - (31%)	Gaps:	211/693 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LYRCVGSRLPVITRNMEAHELE----------PFRRTDSLSIFQIPAAEKGDSLVRRILDMLNPH 112
            :..|....|..|.:  :|:||:          |...|.|:...::...|...:.| |::|..:.|
  Fly   211 ILHCAPDNLLKILQ--QANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTV-RLMDPSDFH 272

  Fly   113 ---------QRRKHMHKYLFVWPNAGRHQLLRLFRGSW------------------------AKK 144
                     :|.|...:|..|.||..:.|::.|....|                        .|.
  Fly   273 VKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKP 337

  Fly   145 LLYGLAI------------TGR----ENGTFDF--------------DPFAW---GGLQVIQRLD 176
            ..:|..|            |||    |||...|              |...|   .||.|:.  |
  Fly   338 WPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLN--D 400

  Fly   177 GEVPYARKVKDLRGYP-LRFSMFTDPLMAMPRSPVE---TAGYQAVDGVAARVVGE---MLNASV 234
            .|....|..:.|.... :..|....|.:.: |.|.|   ..|....:|.:..::.|   |||...
  Fly   401 DEESEKRVGQKLSNKTFIVSSRLGAPFLTL-REPQEGEILTGNSRYEGYSIDLINEIAKMLNFKF 464

  Fly   235 TYVFPEDNESYGRCLPNGNY----------TGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPY 289
            .:          |..|:|.|          .|:|..::.|:.........:......||:...|:
  Fly   465 EF----------RMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPF 519

  Fly   290 TRRNLHLVVPASAIQPEYLI-FVRVFRRTVWYLLLVTLLVVVLVFWVMQRL-----QRRIPRRGV 348
            ....:.::.......|..|. |:..|...||..:....|.:.|:.:.:.|:     :...|.:..
  Fly   520 MTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEP 584

  Fly   349 IQFQ-------ATWYEILEMFGKTHVGEPAGRLSSFSSMRTFLMGWILFSYVLSTIYFAKLESGF 406
            .:.:       .||..|..:     :|:....|...:|.|.....|..|:.::...|.|.|.:..
  Fly   585 EEVENIWSIMNTTWLSIGSL-----MGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644

  Fly   407 VRPSYEEQVDRVDDLVHLDVHIYAVTTMYDAVRSALTEHQYGLL-----------ENRSRQLPLG 460
            ........::..:||                  :|.::.:||.:           .|.|....:.
  Fly   645 TNSRQANSINSAEDL------------------AAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMW 691

  Fly   461 IATSYYQPVV--RRRDRRAAFIMRDFHARDFL--AITYDSQAER-------------PAYHIARE 508
            .|.....|.|  :..|.....:.:..:...||  :.|.:...||             .:|.||
  Fly   692 TAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIA-- 754

  Fly   509 YLRSMICTYILPRGSPFLHRLESLYSGFLEHGFF-----EHWRQMDLITRVGASPDAEEFLEDLG 568
                      :|..||:..::.:......|.|..     :.|::|.      ...:.|:..||.|
  Fly   755 ----------MPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMH------GGGNCEKSDEDGG 803

  Fly   569 DQTDTDSGSNELAIRNKK---VVLTLDILQGAF-----YLWSV 603
            |       :.||.:.|..   :||.|.:|....     :||:|
  Fly   804 D-------TPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNV 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	55/324 (17%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	36/187 (19%)
		ANF_receptor	39..379	CDD:279440	33/170 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	67/418 (16%)
		Lig_chan	548..812	CDD:278489	51/311 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930