Protein Alignment Ir68b and GRIK4

DIOPT Version :9

• Sequence 1: NP_648548.1
• Gene: Ir68b / 39378
• FlyBaseID: FBgn0036250
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001269399.1
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 111/604 - (18%)
• Similarity: 195/604 - (32%)
• Gaps: 207/604 - (34%)

  Fly    30 QNVQVTYLYRCASCPASFDADYSALELDLYRCVGSRLPVITRNMEAHELEPFRRTDSLSIFQIPA 94
            |::..::...|...|.:..|..|||..|....|.:.:..:.|:.|. .::|. ...|..|:|
Human   283 QSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEI-GVKPL-SCGSAQIWQ--- 342

  Fly    95 AEKGDSLVRRI----LDMLNPH-------QRRKHMHKYLFVWPNAGRHQLLRLFRGSWAKKLLYG 148
              .|.||:..:    |:.|..|       ||..:..|.|....| |..|:     |.|  .:..|
Human   343 --HGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRN-GFRQI-----GQW--HVAEG 397

  Fly   149 LAITGRENGTFDFDPFAWGGLQVIQRLDGEVPYARKVKDLRGYPLRFSMFT----------DPLM 203
            |:                        :|..: ||..:.|        ::|.          :|.:
Human   398 LS------------------------MDSHL-YASNISD--------TLFNTTLVVTTILENPYL 429

  Fly   204 AMPRSPVETAGYQAVDGVAARVVGEM-----LNASVTYVFPEDNESYGRCLPNGNYTGVVSDI-- 261
            .:..:..|..|....:|....::.|:     .|..:..|   .:..||....||.:||:|.::
Human   430 MLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLV---GDGVYGVPEANGTWTGMVGELIA 491

  Fly   262 ------VGGHTHFAPNSRFVLDCIWP----AVEVLYPYTRRNLHLVVPASAIQPEYLIFVRVFRR 316
                  |.|.|..|...: |:|...|    .:.:||     .:|:     ..:|.|..|:..|..
Human   492 RKADLAVAGLTITAEREK-VIDFSKPFMTLGISILY-----RVHM-----GRKPGYFSFLDPFSP 545

  Fly   317 TVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWYEILEMFGKTHVGEPA--GRLS---- 375
            .||..:|:..|.|..|.:::.||.           ...||.          ..|.  ||.:
Human   546 GVWLFMLLAYLAVSCVLFLVARLT-----------PYEWYS----------PHPCAQGRCNLLVN 589

  Fly   376 --SFSSMRTFLMG----------------------WILFSYVLSTIYFAKLESGFVRPSYEEQVD 416
              |..:...|.:|                      |..|:.::.:.|.|.|.:.......:..::
Human   590 QYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIE 654

  Fly   417 RVDDLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIM 481
            .||||               |.::|:   :||.:...|
Human   655 SVDDL---------------ADQTAI---EYGTIHGGS--------------------------- 674

  Fly   482 RDFHARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHR-LESLYSGFLEHGFFEHW 545
                     ::|:...:....|.....|:.|...:..:......:.| |.|.|:..||....|::
Human   675 ---------SMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYY 730

  Fly   546 RQMDL-ITRVGASPDAEEF 563
            ||.:. :|::|...|.:.:
Human   731 RQRNCNLTQIGGLLDTKGY 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	40/263 (15%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	32/155 (21%)
		ANF_receptor	43..382	CDD:279440	25/105 (24%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	74/424 (17%)
		Lig_chan	547..816	CDD:278489	46/278 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840