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Protein Alignment Ir68b and GRIK2

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	574	Identity:	96/574 - (16%)
Similarity:	175/574 - (30%)	Gaps:	201/574 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FDADYSALELDLYRCVGSRLPVITRNM-EAHELEPFRRTDSLSIFQIPAAEKGDSLVRRILDMLN 110
            ||.|..:|:.:....:|:..|....|| |:.:.:|...|||||        ....:|..||:
Human   387 FDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLS--------NRSLIVTTILE--- 440

  Fly   111 PHQRRKHMHKYLFVWPNAGRHQLLRLFRGSWAKKLLYGLAITGRENGTFDFDPFAWGGLQVIQRL 175
                    ..|:             ||:.|  .|.|||                       ..|.
Human   441 --------EPYV-------------LFKKS--DKPLYG-----------------------NDRF 459

  Fly   176 DGE-VPYARKVKDLRGYPLRFSMFTDPLMAMPRSPVETAGYQAVDGVAARVVGEMLNASVTYVFP 239
            :|. :...|::..:.|:.....:            ||...|.|.|..
Human   460 EGYCIDLLRELSTILGFTYEIRL------------VEDGKYGAQDDA------------------ 494

  Fly   240 EDNESYGRCLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVV-PASAI 303
                       ||.:.|:|.:::......|.....:.......::...|:....:.::. ..:..
Human   495 -----------NGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT 548

  Fly   304 QPEYLIFVRVFRRTVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWY---------EIL 359
            .|....|:......:|..:|:..|.|..|.:|:.|..           ...||         :::
Human   549 NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFS-----------PYEWYNPHPCNPDSDVV 602

  Fly   360 E---------MFGKTHVGEPAGRLSSFSSMRTFLMG--WILFSYVLSTIYFAKLESGFVRPSYEE 413
            |         .||...:.:....|.. .::.|.::|  |..|:.::.:.|.|.|.:.......|.
Human   603 ENNFTLLNSFWFGVGALMQQGSELMP-KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMES 666

  Fly   414 QVDRVDDLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAA 478
            .:|..|||                  :..|:.:||.:|
Human   667 PIDSADDL------------------AKQTKIEYGAVE--------------------------- 686

  Fly   479 FIMRDFHARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHR-LESLYSGFLEHGFF 542
                     |...:|:..:::...|.....::.|...:.::......:.| |.|.|:..:|....
Human   687 ---------DGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTI 742

  Fly   543 EHWRQMDL-ITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQ 595
            |...|.:. :|::|...|::      |....|..||   ..|:|   :|:.|||
Human   743 EFVTQRNCNLTQIGGLIDSK------GYGVGTPMGS---PYRDK---ITIAILQ 784

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.