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Protein Alignment Ir68b and GRIK1

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	633	Identity:	107/633 - (16%)
Similarity:	199/633 - (31%)	Gaps:	181/633 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DYSALELDLYR-----CVGSRL---------PVITR-NMEAHELEPFRRTDSL------------ 87
            |..||:|:|||     ..|.||         .:|.: :||..:..|...|..|
Human   261 DLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMY 325

  Fly    88 -SIFQIPAAEKGDSLVRRILDMLNPHQRRKHMHKYLFVWPNAGRHQLLRLFRGSWAKKLLYGLAI 151
             :::.:..|....|       .|.....:.|.||   .|....|...| :....|..  |.|...
Human   326 DAVYMVAIASHRAS-------QLTVSSLQCHRHK---PWRLGPRFMNL-IKEARWDG--LTGHIT 377

  Fly   152 TGRENG---TFDFDPFA--------------------------WGGLQVIQRLDGEVPYARKVKD 187
            ..:.||   .||.|..:                          |.....:...|.....:..:.|
Human   378 FNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITD 442

  Fly   188 -LRGYPLRF-SMFTDPLMAMPRSPVETAGYQAVDGVAARVVGEMLNASVTYVF-----PEDNESY 245
             |....|.. ::..:|.:...:|.....|....:|....::.|:.|. :.:::     |:.  .|
Human   443 SLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNI-LGFIYDVKLVPDG--KY 504

  Fly   246 GRCLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVV-PASAIQPEYLI 309
            |.....|.:.|:|.:::......|.....:.......::...|:....:.::. ..:...|....
Human   505 GAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS 569

  Fly   310 FVRVFRRTVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWY---------EILE----- 360
            |:......:|..:|:..|.|..|.:|:.|..           ...||         :::|
Human   570 FLNPLSPDIWMYVLLACLGVSCVLFVIARFT-----------PYEWYNPHPCNPDSDVVENNFTL 623

  Fly   361 ----MFGKTHVGEPAGRLSSFSSMRTFLMG--WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVD 419
                .||...:.:....|.. .::.|.::|  |..|:.::.:.|.|.|.:.......|..:|..|
Human   624 LNSFWFGVGALMQQGSELMP-KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSAD 687

  Fly   420 DLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIMRDF 484
            ||                  :..|:.:||.:
Human   688 DL------------------AKQTKIEYGAV---------------------------------- 700

  Fly   485 HARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHR-LESLYSGFLEHGFFEHWRQM 548
              ||...:|:..:::...|.....::.|...|.::......:.| |.:.|:..:|....|:..|.
Human   701 --RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQR 763

  Fly   549 DL-ITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQ 595
            :. :|::|...|::      |....|..||   ..|:|   :|:.|||
Human   764 NCNLTQIGGLIDSK------GYGVGTPIGS---PYRDK---ITIAILQ 799

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.