Protein Alignment Ir68b and GRIA3

DIOPT Version :9

• Sequence 1: NP_648548.1
• Gene: Ir68b / 39378
• FlyBaseID: FBgn0036250
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 92/562 - (16%)
• Similarity: 182/562 - (32%)
• Gaps: 181/562 - (32%)

  Fly   157 GTFDFDPFAWGGLQVIQRLDGEVPYARKVKDLR--GYPLRFSMFTDPLMAMPRSPVETAGYQAVD 219
            |...||.:   |.:....:|   .|..||...|  ||...:..|      :|.|..:.:...|..
Human   368 GNIQFDTY---GRRTNYTID---VYEMKVSGSRKAGYWNEYERF------VPFSDQQISNDSASS 420

  Fly   220 GVAARVVGEMLNASVTYVF-------PEDNESY-GRCLP-------------------NGNY--- 254
            .....||..:|.:  .||.       .|.||.| |.|:.                   :|.|
Human   421 ENRTIVVTTILES--PYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGAR 483

  Fly   255 -------TGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVV--PASAIQPEYLIF 310
                   .|:|.::|.|....|.....:.......::...|:....:.:::  |..: :|....|
Human   484 DPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS-KPGVFSF 547

  Fly   311 VRVFRRTVWYLLLVTLLVVVLVFWVMQRL------------QRRIPRR--------GVIQFQATW 355
            :......:|..::...:.|.:|.:::.|.            :.|.|:.        |:  |.:.|
Human   548 LDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGI--FNSLW 610

  Fly   356 YEILEMFGKTHVGEPAGRLSSFSSMRTFLMG--WILFSYVLSTIYFAKLESGFVRPSYEEQVDRV 418
            :.:.....:       |...|..|:...::|  |..|:.::.:.|.|.|.:..........::..
Human   611 FSLGAFMQQ-------GCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESA 668

  Fly   419 DDLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIMRD 483
            :||                  :..||..||.|::.|                          .::
Human   669 EDL------------------AKQTEIAYGTLDSGS--------------------------TKE 689

  Fly   484 FHARDFLAITYDSQAERPAYHIAREYLRS---MICTYILPRGSPFLHRLESLYSGFLE---HGFF 542
            |..|..:|:          |.....|::|   .:.|.....|...:.:.:..::..||   :.:.
Human   690 FFRRSKIAV----------YEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYI 744

  Fly   543 EHWRQMDLITRVGASPDAEEF--------------------LEDLG-----------DQTDTDSG 576
            |..:..|.: :||.:.|::.:                    |.:.|           |:.:..||
Human   745 EQRKPCDTM-KVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG 808

  Fly   577 SNELAIRNKKVVLTLDILQGAFYLWSVGIGISCLGFAVEHAH 618
            ..:  .::|...|:|..:.|.||:...|:|::.:...:|..:
Human   809 GGD--SKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	50/332 (15%)
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	13/52 (25%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	66/449 (15%)
		Glutamate binding. /evidence=ECO:0000250	508..510		0/1 (0%)
		Glutamate binding. /evidence=ECO:0000250	686..687		1/26 (4%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930