DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir68b and GRIA2

DIOPT Version :9

Sequence 1:NP_648548.1 Gene:Ir68b / 39378 FlyBaseID:FBgn0036250 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens


Alignment Length:661 Identity:114/661 - (17%)
Similarity:212/661 - (32%) Gaps:207/661 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 SLSIFQIPAAEKGDSLVRRILDMLNPHQRRKH--MHKYLFVWPNAGRHQLLRLFRGSWAKKLLYG 148
            ::|.|||  .:..||||.:.::..:..:.:::  .|.....:.:|..:..:::...::.......
Human   256 NVSGFQI--VDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQR 318

  Fly   149 LAITGREN-GTFDFDP-FAWG-GLQV--------IQRLDGEVP---------YARKVKDLR---- 189
            :.|:.|.| |....:| ..|| |:::        ::.|.|.:.         |...:.:|:    
Human   319 IEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGP 383

  Fly   190 ---GYPLRFSMFTDPLMAMPRSPVETAGYQAVDGVAARVV----------GEMLNASVTYVFPED 241
               ||..........|..:| |..:|:|.:....|...::          .|||         |.
Human   384 RKIGYWSEVDKMVVTLTELP-SGNDTSGLENKTVVVTTILESPYVMMKKNHEML---------EG 438

  Fly   242 NESY-GRCLP-------------------NGNY----------TGVVSDIVGGHTHFAPNSRFVL 276
            ||.| |.|:.                   :|.|          .|:|.::|.|....|.....:.
Human   439 NERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503

  Fly   277 DCIWPAVEVLYPYTRRNLHLVV--PASAIQPEYLIFVRVFRRTVWYLLLVTLLVVVLVFWVMQRL 339
            ......::...|:....:.:::  |..: :|....|:......:|..::...:.|.:|.:::.|.
Human   504 LVREEVIDFSKPFMSLGISIMIKKPQKS-KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 567

  Fly   340 QRRIPRRGVIQFQATWY-EILEMFGKTHVGEPAGRLSSFSSMRTFLMG----------------- 386
            .           ...|: |..|...:|...|.......|:|: .|.:|                 
Human   568 S-----------PYEWHTEEFEDGRETQSSESTNEFGIFNSL-WFSLGAFMQQGCDISPRSLSGR 620

  Fly   387 -----WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLVHLDVHIYAVTTMYDAVRSALTEHQ 446
                 |..|:.::.:.|.|.|.:..........::..:||                  |..||..
Human   621 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL------------------SKQTEIA 667

  Fly   447 YGLLENRSRQLPLGIATSYYQPVVRRRDRRAAF-----IMRDFHARDFLAITYDSQAE------R 500
            ||.|::       |....::     ||.:.|.|     .||......|:..|.:..|.      :
Human   668 YGTLDS-------GSTKEFF-----RRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK 720

  Fly   501 PAYHIAREYLRSMICTYI-----------------------LPRGSPFLHRLESLYSGFLEHGFF 542
            .||     .|.|.:..||                       .|:||.....:........|.|..
Human   721 YAY-----LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVL 780

  Fly   543 EHWRQMDLITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQGAFYLWSVGIGI 607
            :..:              .::..|.|:....||||.|     |...|:|..:.|.||:...|:|:
Human   781 DKLK--------------NKWWYDKGECGAKDSGSKE-----KTSALSLSNVAGVFYILVGGLGL 826

  Fly   608 SCLGFAVEHAH 618
            :.|...:|..:
Human   827 AMLVALIEFCY 837

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir68bNP_648548.1 Lig_chan 333..607 CDD:278489 58/330 (18%)
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 24/143 (17%)
PBP2_iGluR_AMPA 413..794 CDD:270433 70/451 (16%)
Glutamate binding 499..501 0/1 (0%)