DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68b and Grin2c

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	86/451 - (19%)
Similarity:	154/451 - (34%)	Gaps:	143/451 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 NESYGRCLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVVPAS--AIQ 304
            |..:|:.: .|.:.|::.::.......|..|..:.:.....::...|:....:.::|..|  .:.
  Rat   493 NGKHGKRV-RGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVS 556

  Fly   305 PEYLIFVRVFRRTVWYLLLVTLLVVVLVFWVM----------QRLQRRIPRRGVIQF---QATWY 356
            |.  .|:..:...||.::.|..|.||.:...|          |.|.:. .:.|...|   ::.|.
  Rat   557 PS--AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKG-KKPGGPSFTIGKSVWL 618

  Fly   357 EILEMFGKT-HVGEPAGRLSSFSSMRTFLMGWILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDD 420
            ....:|..: .:..|.|..|     :..::.|..|:.:....|.|.|.:..::..|.:.|..:.|
  Rat   619 LWALVFNNSVPIENPRGTTS-----KIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSD 678

  Fly   421 LV----------------------------HLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQL 457
            ..                            :.|:|.:.|.....:|..|||..:.|.|:
  Rat   679 KKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLD------ 737

  Fly   458 PLGIATSYYQPVVRRRDRRAAFIMRDFHARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRG 522
                                |||             ||                :.:..|:  .|
  Rat   738 --------------------AFI-------------YD----------------AAVLNYM--AG 751

  Fly   523 SPFLHRLESLYSG--FLEHGF------FEHW-RQMDLITRVGASPDAEEFLEDLGD------QTD 572
            .....:|.::.||  |...|:      ..|| |.:||           ..|:.|||      :|.
  Rat   752 KDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDL-----------ALLQLLGDGETQKLETV 805

  Fly   573 TDSG--SNELAIRNKKVVLTLDI--LQGAFYLWSVGIGISCLGFAVEHAHWFWRRQTLRNA 629
            ..||  .||   :|:.:...|||  :.|.||:..|.:|::.|.||.||..::..|.::.|:
  Rat   806 WLSGICQNE---KNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	61/334 (18%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	68/396 (17%)
		NMDAR2_C	850..>925	CDD:402274	3/14 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930