DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68b and Grik5

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	98/489 - (20%)
Similarity:	165/489 - (33%)	Gaps:	137/489 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 AGYQAVDGVAA---RVVGEMLNASVTYVFPEDNESYGRCLPNGNYTGVVSDI---------VGGH 265
            :|.:..:|...   |.:.|:|.........||. .||...|||::||:|.::         |...
  Rat   438 SGNERFEGFCVDMLRELAELLRFRYRLRLVEDG-LYGAPEPNGSWTGMVGELINRQKADLAVAAF 501

  Fly   266 THFAPNSRFVLDCIWP----AVEVLYPYTRRNLHLVVPASAIQPEYLIFVRVFRRTVWYLLLVTL 326
            |..|...: |:|...|    .:.:||     .:|:     ..:|.|..|:..|...||..:|:..
  Rat   502 TITAEREK-VIDFSKPFMTLGISILY-----RVHM-----GRKPGYFSFLDPFSPAVWLFMLLAY 555

  Fly   327 LVVVLVFWVMQRLQ-----------RRIPRRGVIQFQAT-----WYEILEMFGKTHVGEPAGRLS 375
            |.|..|.::..||.           |..|.  :::.|.|     |:.:            .|.:.
  Rat   556 LAVSCVLFLAARLSPYEWYNPHPCLRARPH--ILENQYTLGNSLWFPV------------GGFMQ 606

  Fly   376 SFS-------SMRTFLMGWILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLV------HLDVH 427
            ..|       |.|.....|..|:.::.:.|.|.|.:.......|..|:..|||.      :..:|
  Rat   607 QGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIH 671

  Fly   428 IYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFI----MRDFHARD 488
            ..:..|.:...|....:..:..::::.   |.....|..:.:.|..:.|.||:    |.::|.|.
  Rat   672 AGSTMTFFQNSRYQTYQRMWNYMQSKQ---PSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRL 733

  Fly   489 FLAIT-YDSQAERPAYHIAREYLRSMICTYILPRGSPFLHRLESLYSGFLEHGFFEHWRQMDLIT 552
            ...:| .....:...|.|.            :|.||||...:........|:      .:::::.
  Rat   734 NCNLTQIGGLLDTKGYGIG------------MPLGSPFRDEITLAILQLQEN------NRLEILK 780

  Fly   553 RV----GASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQGAFYLWSVGIGISCLGFA 613
            |.    |..|..|            |..:..|.:.|         :.|.|.:...|: |..:..|
  Rat   781 RKWWEGGRCPKEE------------DHRAKGLGMEN---------IGGIFVVLICGL-IIAVFVA 823

  Fly   614 VEHAHWFWRR--------------QTLRNAVEAR 633
            |....|..||              |.||:||..|
  Rat   824 VMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	52/311 (17%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	77/393 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930