DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68b and Grin2b

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	696	Identity:	136/696 - (19%)
Similarity:	238/696 - (34%)	Gaps:	192/696 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QVTYLYRCASCPASFDADYSALELDLYR----CVGSRLPVITRNMEAHELE---PFRRTDSLSIF 90
            :.||::..|:........|:.:...|..    .|.|..|....::...|.:   |.|..|.::|.
Mouse   236 EATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAII 300

  Fly    91 QIPAAEKGDSLVRRILDMLNPHQRRKHMHKYLFV-WPNA---GRHQLLRLFRGSWAKKLLYGLAI 151
            ...|:           |||:.|.         |: .|.:   ..|: .|:::.:...:.|..:..
Mouse   301 TTAAS-----------DMLSEHS---------FIPEPKSSCYNTHE-KRIYQSNMLNRYLINVTF 344

  Fly   152 TGRENGTFDFDPFAWGGLQVIQRLDGEVPYAR--KVKDLRGYPLRFSMFTDPLMAMPRS------ 208
            .|| |.:|..|.:......||..|:.|..:.|  |.||   ..|:...:..|.|. |.:
Mouse   345 EGR-NLSFSEDGYQMHPKLVIILLNKERKWERVGKWKD---KSLQMKYYVWPRMC-PETEEQEDD 404

  Fly   209 -----PVETAGYQAVDGV--------------AARVVGE-----------------------MLN 231
                 .:|.|.:..|:.|              ..|::.|                       .::
Mouse   405 HLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKIS 469

  Fly   232 ASVTYVFP---EDNESYGRCLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRN 293
            .||.:.:.   ..|..:|:.: ||.:.|::.::|....:.|..|..:.:.....|:...|:....
Mouse   470 KSVKFTYDLYLVTNGKHGKKI-NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETG 533

  Fly   294 LHLVVPAS--AIQPEYLIFVRVFRRTVWYLLLVTLLVV----VLVFWVMQRL-------QRRIPR 345
            :.::|..|  .:.|.  .|:..|...||.::.|.||:|    |.||.....:       ..|.|
Mouse   534 ISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREP- 595

  Fly   346 RGVIQF---QATWYEILEMFG-----KTHVGEPAGRLSSFSSMRTFLMGWILFSYVLSTIYFAKL 402
             |...|   :|.|.    ::|     ...|..|.|..|     :..:..|..|:.:....|.|.|
Mouse   596 -GGPSFTIGKAIWL----LWGLVFNNSVPVQNPKGTTS-----KIMVSVWAFFAVIFLASYTANL 650

  Fly   403 ESGFVRPSYEEQVDRVDDLVHLDVHIYAVTTMYDAVRSALTE----------HQY-GLLENRSRQ 456
            .:..::..|.:||..:.|......:.::....:..|.:..||          |.| |....|
Mouse   651 AAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQR--- 712

  Fly   457 LPLGIATSYYQPVVRRRDRRAAFIMRDFHARDFLAITYDSQAERPAYHIAREYLRSMICTYILPR 521
               |:..:.......:.|   |||             ||                :.:..|:..|
Mouse   713 ---GVDDALLSLKTGKLD---AFI-------------YD----------------AAVLNYMAGR 742

  Fly   522 GSPFLHRLESLYSG--FLEHGF------FEHW-RQMDL-ITRVGASPDAEEFLEDLGDQTDTDSG 576
            ....  :|.::.||  |...|:      ...| ||:|| |.::....:.|| ||.|.......:.
Mouse   743 DEGC--KLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEE-LEALWLTGICHNE 804

  Fly   577 SNELAIRNKKVVLTLDILQGAFYLWSVGIGISCLGFAVEHAHWFWR 622
            .||:....    |.:|.:.|.||:....:.:|.:.|..||. ::|:
Mouse   805 KNEVMSSQ----LDIDNMAGVFYMLGAAMALSLITFICEHL-FYWQ 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	60/309 (19%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	37/176 (21%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	84/454 (19%)
		NMDAR2_C	840..1482	CDD:402274	2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846459
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930