DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68b and Grik1

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	519	Identity:	93/519 - (17%)
Similarity:	158/519 - (30%)	Gaps:	134/519 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DYSALELDLYR-----CVGSRL---------PVITR-NMEAHELEPFRRTDSL-SIFQIPAAEKG 98
            |..||:|:|||     ..|.||         .:|.: :||..:..|...|..| .:....||...
Mouse   261 DLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGVMTTEAALMY 325

  Fly    99 D-----SLVRRILDMLNPHQRRKHMHKYLFVWPNAGRHQLLRLFRGSWAKKLLYGLAITGR--EN 156
            |     ::.......|.....:.|.||   .|....|...| :....|.       .:|||  .|
Mouse   326 DAVYMVAIASHRASQLTVSSLQCHRHK---PWRLGPRFMNL-IKEARWD-------GLTGRITFN 379

  Fly   157 GT------FDFDPFA--------------------------WGGLQVIQRLDGEVPYARKVKD-L 188
            .|      ||.|..:                          |.....:...||....:..:.| |
Mouse   380 KTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSL 444

  Fly   189 RGYPLRF-SMFTDPLMAMPRSPVETAGYQAVDGVAARVVGEMLN-ASVTY---VFPEDNESYGRC 248
            ....|.. ::..:|.:...:|.....|....:|....::.|:.| ....|   :.|:.  .||..
Mouse   445 ANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDG--KYGAQ 507

  Fly   249 LPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVV-PASAIQPEYLIFVR 312
            ...|.:.|:|.:::......|.....:.......::...|:....:.::. ..:...|....|:.
Mouse   508 NDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLN 572

  Fly   313 VFRRTVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWY---------EILE-------- 360
            .....:|..:|:..|.|..|.:|:.|..           ...||         :::|
Mouse   573 PLSPDIWMYVLLACLGVSCVLFVIARFT-----------PYEWYNPHPCNPDSDVVENNFTLLNS 626

  Fly   361 -MFGKTHVGEPAGRLSSFSSMRTFLMG--WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLV 422
             .||...:.:....|.. .::.|.::|  |..|:.::.:.|.|.|.:.......|..:|..|||.
Mouse   627 FWFGVGALMQQGSELMP-KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA 690

  Fly   423 HLDVHIYAVTTMYDAVRSALT---------------------EHQYGLLENRSRQLPLGIATSY 465
            .      .....|.|||...|                     ..|..|::|....:...:.|.|
Mouse   691 K------QTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDY 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	30/174 (17%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	36/180 (20%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	53/323 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846572
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930