DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68b and Grid1

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	527	Identity:	108/527 - (20%)
Similarity:	184/527 - (34%)	Gaps:	149/527 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 RENGTFDFDPFAWGGLQ---VIQRLDG---------EVPYARKVKDLRGYPLRFSMFT-DPLMAM 205
            |:..|:|.:....|.||   :..||.|         |.|:....:::.|.|.|:..|: |.|.|:
Mouse   410 RKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDAL 474

  Fly   206 PRSPVETAG-----YQAVDGVAARVVGEMLNASVTYVFPEDNESYGRCLPNGNYTGVVSDIVGGH 265
            .::    .|     |||.||                       .||..|.|.::.|::.:::...
Mouse   475 AKA----LGFKYEIYQAPDG-----------------------RYGHQLHNTSWNGMIGELISKR 512

  Fly   266 THFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVVPASAIQPEYLIFV----RVFRRTVWYLLLVTL 326
            ...|.::    ..|.|..|.:..:::|.:...|.....:||..|.:    ..|...||..:...:
Mouse   513 ADLAISA----ITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAI 573

  Fly   327 LVVVLVFWVMQRLQ--------RRIPRRGVIQFQATWY---EILEMFGKTHVGEPAGRLSSFSSM 380
            .||.::.:|:.|:|        :..|........|.|.   ..::..|::.|...|        |
Mouse   574 PVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVA--------M 630

  Fly   381 RTFLMGWILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLVHLDVHIYAVTTM-YDAVR-SALT 443
            |..:..|.||:.::.:.|.|.| :.|:      .|.|:|:.:.....:.....| |..|| ||:.
Mouse   631 RIVMGSWWLFTLIVCSSYTANL-AAFL------TVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVY 688

  Fly   444 EH----QYGLLENRSRQLPL--------GIATSYYQPV--VRRRDRRAAFIMRDFHARDFLAITY 494
            |:    ....||..|....|        |.......|.  :|:..:.....:.|....::.|:|.
Mouse   689 EYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFLWDVAVVEYAALTD 753

  Fly   495 D--------SQAERPAYHIAREYLRSMICTYILPRGSP----FLHRLESLYS----GFLEHGFFE 543
            |        :......|.||            |..|||    |..|:..|..    ..|:..::.
Mouse   754 DDCSVTVIGNSISSKGYGIA------------LQHGSPYRDLFSQRILELQDTGDLDVLKQKWWP 806

  Fly   544 HWRQMDLITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQGAFYLWSVGIGIS 608
            |..:.||.:.               ..|.|:..|           |.|....|.|.:.::|:.::
Mouse   807 HTGRCDLTSH---------------SSTQTEGKS-----------LKLHSFAGVFCILAIGLLLA 845

  Fly   609 CLGFAVE 615
            ||..|:|
Mouse   846 CLVAALE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	61/316 (19%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		8/25 (32%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	3/12 (25%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	85/427 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840