Protein Alignment Ir68b and Gria2

DIOPT Version :10

• Sequence 1: NP_648548.1
• Gene: Ir68b / 39378
• FlyBaseID: FBgn0036250
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 661
• Identity: 114/661 - (17%)
• Similarity: 212/661 - (32%)
• Gaps: 207/661 - (31%)

  Fly    86 SLSIFQIPAAEKGDSLVRRILDMLNPHQRRKH--MHKYLFVWPNAGRHQLLRLFRGSWAKKLLYG 148
            ::|.|||  .:..||||.:.::..:..:.:::  .|.....:.:|..:..:::...::.......
Mouse   256 NVSGFQI--VDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQR 318

  Fly   149 LAITGREN-GTFDFDP-FAWG-GLQV--------IQRLDGEVP---------YARKVKDLR---- 189
            :.|:.|.| |....:| ..|| |:::        ::.|.|.:.         |...:.:|:
Mouse   319 IEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGP 383

  Fly   190 ---GYPLRFSMFTDPLMAMPRSPVETAGYQAVDGVAARVV----------GEMLNASVTYVFPED 241
               ||..........|..:| |..:|:|.:....|...::          .|||         |.
Mouse   384 RKIGYWSEVDKMVVTLTELP-SGNDTSGLENKTVVVTTILESPYVMMKKNHEML---------EG 438

  Fly   242 NESY-GRCLP-------------------NGNY----------TGVVSDIVGGHTHFAPNSRFVL 276
            ||.| |.|:.                   :|.|          .|:|.::|.|....|.....:.
Mouse   439 NERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503

  Fly   277 DCIWPAVEVLYPYTRRNLHLVV--PASAIQPEYLIFVRVFRRTVWYLLLVTLLVVVLVFWVMQRL 339
            ......::...|:....:.:::  |..: :|....|:......:|..::...:.|.:|.:::.|.
Mouse   504 LVREEVIDFSKPFMSLGISIMIKKPQKS-KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 567

  Fly   340 QRRIPRRGVIQFQATWY-EILEMFGKTHVGEPAGRLSSFSSMRTFLMG----------------- 386
            .           ...|: |..|...:|...|.......|:|: .|.:|
Mouse   568 S-----------PYEWHTEEFEDGRETQSSESTNEFGIFNSL-WFSLGAFMQQGCDISPRSLSGR 620

  Fly   387 -----WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLVHLDVHIYAVTTMYDAVRSALTEHQ 446
                 |..|:.::.:.|.|.|.:..........::..:||                  |..||..
Mouse   621 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL------------------SKQTEIA 667

  Fly   447 YGLLENRSRQLPLGIATSYYQPVVRRRDRRAAF-----IMRDFHARDFLAITYDSQAE------R 500
            ||.|::       |....::     ||.:.|.|     .||......|:..|.:..|.      :
Mouse   668 YGTLDS-------GSTKEFF-----RRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK 720

  Fly   501 PAYHIAREYLRSMICTYI-----------------------LPRGSPFLHRLESLYSGFLEHGFF 542
            .||     .|.|.:..||                       .|:||.....:........|.|..
Mouse   721 YAY-----LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVL 780

  Fly   543 EHWRQMDLITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQGAFYLWSVGIGI 607
            :..:              .::..|.|:....||||.|     |...|:|..:.|.||:...|:|:
Mouse   781 DKLK--------------NKWWYDKGECGAKDSGSKE-----KTSALSLSNVAGVFYILVGGLGL 826

  Fly   608 SCLGFAVEHAH 618
            :.|...:|..:
Mouse   827 AMLVALIEFCY 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	24/143 (17%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	70/451 (16%)