DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68b and GRIN3B

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_619635.1	Gene:	GRIN3B / 116444	HGNCID:	16768	Length:	1043	Species:	Homo sapiens

Alignment Length:	716	Identity:	141/716 - (19%)
Similarity:	232/716 - (32%)	Gaps:	207/716 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PGIYALAEIA---CRIAVEQNVQVTYLYRCASCPASFDADYSALELDLYRCVGSRLPV------I 69
            ||:.||.|:|   ...|:...||:                       :.|.:||...|      :
Human   276 PGLLALGEVARPPLEAAIHDIVQL-----------------------VARALGSAAQVQPKRALL 317

  Fly    70 TRNMEAHELEP------------FRRTDSLSIFQIPAAEKGDSLVRRILDMLNPHQRRKHMHKYL 122
            ...:...:|:|            |....|......|....|.|.|              ||.::.
Human   318 PAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSSQV--------------HMSRHF 368

  Fly   123 FVWPNAGRHQLLRLFRG--SWAKKLLYGLAITGRENGTFDFDP-------------FAWGGLQVI 172
            .||      .|.|..||  :||       .:....:|..|.:|             ..|..|:|:
Human   369 KVW------SLRRDPRGAPAWA-------TVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV 420

  Fly   173 QRLDGEVPYARKVKDLRGYPLRFSMFTDPLMAMPRSPVETAGYQAV-DGVAARVVGEM------- 229
            ..|:....:||. .|..|......:..||  ....|....|.:.|: :|.|.|.:.:.
Human   421 TLLEHPFVFARD-PDEDGQCPAGQLCLDP--GTNDSATLDALFAALANGSAPRALRKCCYGYCID 482

  Fly   230 LNASVTYVFPEDNESY----GR--CLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYP 288
            |...:....|.|.|.|    |:  .|.:|.:||:|.|::.|..|.|..|..:.......|:...|
Human   483 LLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSP 547

  Fly   289 YTRRNLHLVVPASAIQPEYLIFVRVFRRTVWYLLLVTLLVVVLVFWVMQ-RLQRRIPRRG----- 347
            :...:|.::|.|.........|:.....:.|..:...|.:..|...|.: |....:..||
Human   548 FFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRST 612

  Fly   348 VIQFQAT---WYEILEMFGKTHVGE----PAGRLSSFSSMRTFLMG-WILFSYVLSTIYFAKLES 404
            |..:.:.   .|.||  |.:|...:    |.|||         ||. |.:|..::.:.|.|.|.:
Human   613 VFSYSSALNLCYAIL--FRRTVSSKTPKCPTGRL---------LMNLWAIFCLLVLSSYTANLAA 666

  Fly   405 GFVRPSYEEQVDRV-DDLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQ-----LPLGIAT 463
            ..|.....|::..: |..:|.....:...|::::...|..:..:..:....|:     .|.|:|.
Human   667 VMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAM 731

  Fly   464 SYYQPVVRRRDRRAAFIMRDFHARDFLAITYDSQAE-----RP----AYHIAREYLRSMICTYIL 519
            ....|     .:..|||| |....|: .::.|:..:     :|    .|.|.            |
Human   732 LTSDP-----PKLNAFIM-DKSLLDY-EVSIDADCKLLTVGKPFAIEGYGIG------------L 777

  Fly   520 PRGSPFLHRLESLYSGFLEHGFF----EHWRQMDLITRVGASPDAEEFLEDLGDQTDTDSGSNEL 580
            |:.||....|....|.:...||.    :.|.:|                        ...|....
Human   778 PQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKM------------------------VPCGKRVF 818

  Fly   581 AIRNKKVVLTLDILQGAFYLWSVGIGISCLGFAVEHA----------------HWFWRRQTLRNA 629
            |: .:.:.:::....|.|.|..:|:|.:.|....|||                :|....|.:..|
Human   819 AV-TETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRA 882

  Fly   630 V 630
            :
Human   883 L 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	58/306 (19%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372	34/178 (19%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	90/425 (21%)
		Lig_chan	576..842	CDD:278489	60/320 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930