DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68b and GRIN3A

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	621	Identity:	126/621 - (20%)
Similarity:	188/621 - (30%)	Gaps:	206/621 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 FRGSWAKKLLYGLAITGRENGTF----DFDPF---------AWGGLQVI----------QRLDGE 178
            |||......:.|..|...||..|    ..||.         :|.|.:::          ||....
Human   442 FRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTH 506

  Fly   179 VPYARK----VKDLRGYPLRFSMFTDPLMAMPRSPVETAGYQAVDGVAARVVGEMLNASVTY--V 237
            ..:..|    |..|..:|..|:...|.....|      ||...:|        .|.|.|.|.  :
Human   507 FQHPSKLHLRVVTLIEHPFVFTREVDDEGLCP------AGQLCLD--------PMTNDSSTLDSL 557

  Fly   238 FPEDNES------------YGRCL---------------------------PNGNYTGVVSDIVG 263
            |...:.|            ||.|:                           .||::||:|.|::.
Human   558 FSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLR 622

  Fly   264 GHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVVPASAIQPEYLIFVRVFRRTVWYLLLVTLLV 328
            |..|.|..|..:.......::...|:...:|.::|...........|:.....|:|..:.|.|.:
Human   623 GTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHI 687

  Fly   329 VVLVFWVMQRLQRRIPRRGVIQFQATWYEILEMFGKTHVGEPAGRLSSFSSM----------RT- 382
            ..:..                    |.||....||.|..|....::.||||.          ||
Human   688 TAVFL--------------------TLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTV 732

  Fly   383 -----------FLMG-WILFSYVLSTIYFAKLESGFV-RPSYEEQVDRVDDLVHLDVHIYAVTTM 434
                       |||. |.:|.....:.|.|.|.:..| ...|||.....|..:|.....:...|:
Human   733 AIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTV 797

  Fly   435 -----YDAVRSALTE-HQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIMRDFHARDFLAIT 493
                 .|.||.:..| |:| :........|.|:......|     ::..|||| |....|: .::
Human   798 RESSAEDYVRQSFPEMHEY-MRRYNVPATPDGVEYLKNDP-----EKLDAFIM-DKALLDY-EVS 854

  Fly   494 YDSQAE-----RP----AYHIAREYLRSMICTYILPRGSPFLHRLESLYSGFLEHGFFEHWRQMD 549
            .|:..:     :|    .|.|.            ||..||....:..|.|.:..|||      ||
Human   855 IDADCKLLTVGKPFAIEGYGIG------------LPPNSPLTANISELISQYKSHGF------MD 901

  Fly   550 LI----TRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQGAFYLWSVGIGISCL 610
            ::    .||                  ...|....|: .:.:.:.:....|.|.|..:|.|:|.|
Human   902 MLHDKWYRV------------------VPCGKRSFAV-TETLQMGIKHFSGLFVLLCIGFGLSIL 947

  Fly   611 GFAVEH----------------AHWFWRRQTLRNAV 630
            ....||                .:|....|.|..|:
Human   948 TTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAI 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	66/316 (21%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	8/26 (31%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	95/455 (21%)
		Lig_chan	676..942	CDD:278489	69/330 (21%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		6/33 (18%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930