DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68b and LOC110438919

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	541	Identity:	111/541 - (20%)
Similarity:	195/541 - (36%)	Gaps:	116/541 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 KYLFVWPNAGRHQLLRLFRGSWAKKLLYGLAITGRENGTF----DFDPFAWGGLQVIQRLDGEVP 180
            || .|||.      ..|:.|..|::..: |:|...|...|    |.||.:...::      ..||
Zfish   249 KY-HVWPR------FELYSGPEAREDDH-LSIVTLEEAPFVIVEDVDPLSGTCMR------NTVP 299

  Fly   181 YARKVKDLRGYPLRFSMFTDPLMAMPRSPVETAGY--QAVDGVAARVVGEML-NASVTY-VFPED 241
            ..:::|.|                  ....::|.|  :...|....::.::. |...|| ::...
Zfish   300 CRKQLKAL------------------NQTQDSAVYIKRCCKGFCIDILKKIAKNVKFTYDLYLVT 346

  Fly   242 NESYGRCLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVVPAS--AIQ 304
            |..:|:.: ||.:.|:|.::|..:.|.|..|..:.:.....::...|:....:.::|..|  .:.
Zfish   347 NGKHGKKI-NGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVS 410

  Fly   305 PEYLIFVRVFRRTVWYLLLVTLLVV----VLVFWVM-----QRLQRRIPRRGVIQF---QATWYE 357
            |.  .|:..|...||.::.|.||:|    |.:|...     .|........|...|   :|.|.
Zfish   411 PS--AFLEPFSADVWIMMFVMLLLVSAIAVFIFEYFSPVGYNRCLADGREAGGPSFTIGKAIWL- 472

  Fly   358 ILEMFG-----KTHVGEPAGRLSSFSSMRTFLMGWILFSYVLSTIYFAKLESGFVRPSYEEQVDR 417
               ::|     ...|..|.|..|     :..:..|..|:.:....|.|.|.:..::..|.:||..
Zfish   473 ---LWGLVFNNSVPVQNPRGTTS-----KIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSG 529

  Fly   418 VDDLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIMR 482
            :.|....:.:.::....:..|.:..||..   :.|..|.:     .||   :|:...|.....:.
Zfish   530 LSDKKFQNPNDFSPPFRFGTVPNGSTERN---IRNNYRDM-----HSY---MVKFHQRNVVEALE 583

  Fly   483 DFHARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHRLESLYSG--FLEHGF---- 541
            ........|..||                :.:..|:..|....  :|.::.||  |...|:
Zfish   584 SLKTGKLDAFIYD----------------AAVLNYMAGRDEGC--KLVTIGSGKVFASTGYGIAI 630

  Fly   542 --FEHW-RQMDL-ITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQGAFYLWS 602
              ...| ||:|| |.::....:.|| ||.|..........||:....    |.:|.:.|.||:..
Zfish   631 QKDSGWKRQVDLAILQLFGDGEMEE-LEALWLTGICHHEKNEVMSSQ----LDVDNMAGVFYMLG 690

  Fly   603 VGIGISCLGFAVEHA-HWFWR 622
            ..:.:|.:.|..||. :|..|
Zfish   691 AAMALSLITFIAEHVFYWHMR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	57/296 (19%)
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	4/6 (67%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	90/466 (19%)
		DUF4013	<389..478	CDD:315788	20/94 (21%)
		NMDAR2_C	704..1417	CDD:313729	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930