DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68b and grin2cb

DIOPT Version :9

Sequence 1:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	722	Identity:	139/722 - (19%)
Similarity:	240/722 - (33%)	Gaps:	230/722 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QVTYLYRCAS------------------------CPASFDADYSALELDLYR-----CVGSRLPV 68
            :..||:|.||                        .||||.....::..|.:|     .|...:.:
Zfish   240 EAQYLFRMASDVGLLGPGYIWIVPSLAVGNPEAAPPASFPVGVISIITDRWRKTLRQRVREGVAI 304

  Fly    69 ITRNMEA-HELEPFRRTDSLSIFQIPAAEKGDSLVRRILDMLNPHQRRKHMHKYLFVWPNAGRHQ 132
            |.:.:.: |:...|          ||   :|.|      |..:|  .:.:.:..||      ||.
Zfish   305 IVKGVHSFHKHRGF----------IP---EGHS------DCSSP--VKSYANNSLF------RHM 342

  Fly   133 LLRLFRGSWAKKLLYGLAITGRENGTFDFDPFAWGGLQVIQRLDGEVPYARKVKDLRG------Y 191
            |    ..||..|.|           :|:.|.:......||..||.| .:..||....|      |
Zfish   343 L----NVSWEHKDL-----------SFNSDGYLTNPSMVIIALDRE-NHWDKVGSYEGGILQMRY 391

  Fly   192 PL--RFSMFTDPLMAMPRSPVETAG------YQAVD---GVAAR--------------VVGE--- 228
            |:  |:..|.:|:.......|.|..      .::||   |...|              ::|.
Zfish   392 PVWPRYGSFLEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCRRQSNRTESIIGHTEP 456

  Fly   229 -------------MLNASVTYVFPED-----NESYGRCLPNGNYTGVVSDIVGGHTHFAPNSRFV 275
                         :...|.|..|..|     |..:|: :..|.:.|::.::.......|..|..:
Zfish   457 YTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGK-MVRGVWNGMIGEVFYKRADMAIGSLTI 520

  Fly   276 LDCIWPAVEVLYPYTRRNLHLVVPAS--AIQPEYLIFVRVFRRTVWYLLLVTLLVVVLV-FWVMQ 337
            .:.....|:...|:....:.::|..|  .:.|.  .|:..:...||.::.|..|.||.| .:|.:
Zfish   521 NEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTVFVFE 583

  Fly   338 RLQRRIPRRGVIQFQA-----------TWYEILEMFG-----KTHVGEPAGRLSSFSSMRTFLMG 386
            ........|.::..:|           .|.    ::|     ...:..|.|..|     :..::.
Zfish   584 YFSPVGYNRSLVSAKAPGGPTFTIGKSVWL----LWGIVFNNSVPIENPKGTTS-----KIMVLV 639

  Fly   387 WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLVHLDVHIYAVTTMYDAVRSALTEHQYGLLE 451
            |..|:.:....|.|.|.:..::..|.:.|..:.|            ..:...:......::|.:.
Zfish   640 WAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSD------------KKFQKPQEHYPPFRFGTVP 692

  Fly   452 NRSRQLPLGIATSY---YQPVVRRRDRRAAFIMRDFHARDFLAITYDSQAERPAYHIAREYLRSM 513
            |.|.:  ..|.::|   :..:::...:.....:.........|..||                :.
Zfish   693 NGSTE--RNIRSNYPDMHTHMIKYNQKGVEEALNSLKTGKLDAFIYD----------------AA 739

  Fly   514 ICTYILPRGSPFLHRLESLYSG--FLEHGF------FEHW-RQMDLITRVGASPDAEEFLEDLGD 569
            :..|:  .|.....:|.::.||  |...|:      ...| |.:||           ..|:.|||
Zfish   740 VLNYM--AGKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDL-----------ALLQFLGD 791

  Fly   570 QTDTD-------SG--SNELAIRNKKVVLTLDI--LQGAFYLWSVGIGISCLGFAVEHAHWFWRR 623
             .||.       ||  .||   :|:.:...|||  :.|.||:..|.:|:|.|.||.||. .:|:
Zfish   792 -GDTQRLETVWLSGICQNE---KNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL-LYWK- 850

  Fly   624 QTLRNAV 630
              ||::|
Zfish   851 --LRHSV 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	53/312 (17%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	42/198 (21%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	73/456 (16%)
		NMDAR2_C	845..>932	CDD:313729	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930