DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yps and LIN28A

DIOPT Version :9

Sequence 1:	NP_524033.2	Gene:	yps / 39377	FlyBaseID:	FBgn0022959	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_078950.1	Gene:	LIN28A / 79727	HGNCID:	15986	Length:	209	Species:	Homo sapiens

Alignment Length:	165	Identity:	51/165 - (30%)
Similarity:	64/165 - (38%)	Gaps:	50/165 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADAAESKPLAAEQQQAQQQPEQQQNPPNPQEQDHEQEPLDELQGQQGQPAPPTKEVIATKVTGTV 66
            |.|||..|..|.:..|:...|.|.                 |.|                 .|..
Human    14 AKAAEEAPEEAPEDAARAADEPQL-----------------LHG-----------------AGIC 44

  Fly    67 KWFNVKSGYGFINRN-------DTREDVFVHQSAIARNNPKKAVRSVGDGEVVEFDVVIGEKGNE 124
            |||||:.|:||::..       |...|||||||.:    ..:..||:.:||.|||......||.|
Human    45 KWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKL----HMEGFRSLKEGEAVEFTFKKSAKGLE 105

  Fly   125 AANVTGPSGEPVRGSQFAADKRRNFRPWMKKNRRK 159
            :..||||.|....||:     ||.....|:|.|.|
Human   106 SIRVTGPGGVFCIGSE-----RRPKGKSMQKRRSK 135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yps	NP_524033.2	CSD	62..131	CDD:278729	29/75 (39%)
LIN28A	NP_078950.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		7/16 (44%)
		CSD	42..112	CDD:278729	29/73 (40%)
		Flexible linker	113..136		9/28 (32%)
		AIR1	<120..>183	CDD:331526	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1604809at2759
OrthoFinder	1	1.000	-	-		FOG0000228
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820