DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yps and YBX1

DIOPT Version :9

Sequence 1:	NP_524033.2	Gene:	yps / 39377	FlyBaseID:	FBgn0022959	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_004550.2	Gene:	YBX1 / 4904	HGNCID:	8014	Length:	324	Species:	Homo sapiens

Alignment Length:	369	Identity:	134/369 - (36%)
Similarity:	181/369 - (49%)	Gaps:	85/369 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AEQQQAQQQPEQQQNPPNPQEQDHEQEPLDELQGQQG-------QPAPPTKEVIATKVTGTVKWF 69
            :.:.:.||.|......|.....|.:........|..|       .||...|:||||||.||||||
Human     2 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWF 66

  Fly    70 NVKSGYGFINRNDTREDVFVHQSAIARNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPSGE 134
            ||::||||||||||:|||||||:||.:|||:|.:|||||||.||||||.||||.||||||||.|.
Human    67 NVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGV 131

  Fly   135 PVRGSQFAADKRRNFRPWMKKNRRKDGEVEGEDAESSAQQQQQQAAPIVDGQPQQQVQSGPRQPR 199
            ||:||::|||:....|...::...::.:...:::||..:.:..::||  :||.||         |
Human   132 PVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAP--EGQAQQ---------R 185

  Fly   200 QNFRRGPPGGPPGGPRGGPRGPPGGAPGGPRRYNNYYLRQPRRGLGGGDGSAEPGVHDQNPEGLQ 264
            :.:||                         ||:..||:|:|   .|.....:.|.|..:..||
Human   186 RPYRR-------------------------RRFPPYYMRRP---YGRRPQYSNPPVQGEVMEG-- 220

  Fly   265 RGEGQGPRRGGGPPGGPQR----RFFRRNFNNGPP---PPRRDG--------GEYIQGQGPP--- 311
                 ...:|.|..|.|.|    |.:|..|..|||   .||.||        |:..|||.||
Human   221 -----ADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRR 280

  Fly   312 ----------RPQQPRPR--RQRKPNGPGGGSEQQP--EKNGAQ 341
                      ||:.|:|:  ::.|...|...:...|  |:.||:
Human   281 YRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yps	NP_524033.2	CSD	62..131	CDD:278729	55/68 (81%)
YBX1	NP_004550.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		8/46 (17%)
		Interaction with ss-DNA. /evidence=ECO:0000269\|PubMed:11851341	15..71		21/55 (38%)
		CSD	59..128	CDD:278729	55/68 (81%)
		C5-methylcytosine binding. /evidence=ECO:0000269\|PubMed:31358969, ECO:0007744\|PDB:6A6L	65..70		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..324		69/249 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5793
eggNOG	1	0.900	-	-		E1_COG1278
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3920
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000228
OrthoInspector	1	1.000	-	-		otm41623
orthoMCL	1	0.900	-	-		OOG6_100504
Panther	1	1.100	-	-	O	PTHR11544
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5264
SonicParanoid	1	1.000	-	-		X470
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.890