DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6793 and SYCP1

DIOPT Version :9

Sequence 1:NP_648541.1 Gene:CG6793 / 39369 FlyBaseID:FBgn0036242 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_001269470.1 Gene:SYCP1 / 6847 HGNCID:11487 Length:976 Species:Homo sapiens


Alignment Length:630 Identity:138/630 - (21%)
Similarity:259/630 - (41%) Gaps:124/630 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 EPILREKPPVVISNKRFQRIRAHATQAAKQE-QLHQQQLREEADEKLRIGGEELLRKFAGRNLCI 75
            |..||:|...:..|::.    ..|.:.|.|| |...:::..:.:|.::...:.:....|.|:||.
Human   124 EAELRQKESKLQENRKI----IEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCN 184

  Fly    76 TREEECARELKQLQAEQLEAKRLAEEESKAARLEHQKNRKKRIEAAQKLLEQLRPGPREL----- 135
            ..:|.|||     .||:.:......||::...::...|.:|.|.|.::|..|......|:     
Human   185 LLKETCAR-----SAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLK 244

  Fly   136 ----QCARLQSEVMRSVNVQREVQAEFARVNQQQKE---LDRKIFQEQVLRGFEEAQQRHKEQCQ 193
                :...|:.|..:.:| .:|.|.....:...:||   .|.....|:......:.:::.|.|.:
Human   245 EDYEKIQHLEQEYKKEIN-DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSE 308

  Fly   194 QLSEHKKELLHLIAERE-----RERQATKAKELEEALK---------ERERNERMMKDQQAK--- 241
            .|.:..::..||..|.|     .:|..:..|.|||.|:         ..|:..:|.:..:|:   
Human   309 NLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAH 373

  Fly   242 --------------EKELQAAKQR-KKKDEALASLVMSDQRQKRLQMLEEMEQVRCDIHNKAKGD 291
                          |:.|:..:|| :|.::.|..|.|  :.||:...||||.:    :.|..:.:
Human   374 SFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM--ELQKKSSELEEMTK----LTNNKEVE 432

  Fly   292 LEQLKRDRA-KERVDQRIRRNEKLAKELAPRLHYSAREDE--------ERHKRQLE-EMRKVHSA 346
            ||:||:... ||.:....::.||:|:||      ...|.|        |:....|| ::..:.::
Human   433 LEELKKVLGEKETLLYENKQFEKIAEEL------KGTEQELIGLLQAREKEVHDLEIQLTAITTS 491

  Fly   347 EQ--------AKWRKSKEQAKNARLAVQREEEGLAKKSRQKAEEDRRLAEEQRLQNHQTNVQFKR 403
            ||        .|.....|:.||..|.....:..|..|...:...|..|    .|:|.|.::...:
Human   492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTL----ELKNQQEDINNNK 552

  Fly   404 QQREEHIQRIRKLRQDLDEQVKKRIEEETRPGTNYNREAQLEELREDAFFFDYARQLMDEAQAKG 468
            :|.|..:::|..| |:.:.|::..:|        |.|| :|::.|      |..:..:|:::...
Human   553 KQEERMLKQIENL-QETETQLRNELE--------YVRE-ELKQKR------DEVKCKLDKSEENC 601

  Fly   469 CPLKPFIRAVGQY----KNDNRI--------GAEIRIPRHMITRLPMGRRTQGDSQAEGKEKPSD 521
            ..|:..:....:|    :.:|:.        ..::.:....:.:|.:  ..:...|..|:...:.
Human   602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLEL--ELESAKQKFGEITDTY 664

  Fly   522 KQEPNSEKLSKEEKLLRQKIDENLKKI--EALVLQEGKDKDDQKK 564
            ::|...:|:| ||.||.:.  |..|.|  ||:.||:..||..|.|
Human   665 QKEIEDKKIS-EENLLEEV--EKAKVIADEAVKLQKEIDKRCQHK 706

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6793NP_648541.1 TPH 86..431 CDD:290579 88/406 (22%)
SYCP1NP_001269470.1 SCP-1 28..792 CDD:114219 138/630 (22%)
Mediates head to head self-assembly of N-terminal ends. /evidence=ECO:0000269|PubMed:29915389 101..111
Nuclear localization signal. /evidence=ECO:0000255 117..120
Required for pH-induced assembly of C-terminal ends into antiparallel tetramers. /evidence=ECO:0000269|PubMed:29915389 676..770 14/33 (42%)
Nuclear localization signal. /evidence=ECO:0000255 679..682 1/2 (50%)
DNA-binding. /evidence=ECO:0000269|PubMed:29915389 784..976
Nuclear localization signal. /evidence=ECO:0000255 880..883
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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